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Comparison of Unsatisfactory Samples from Conventional Smear versus Liquid-Based Cytology in Uterine Cervical Cancer Screening Test
Hoiseon Jeong, Sung Ran Hong, Seoung-Wan Chae, So-Young Jin, Hye Kyoung Yoon, Juhie Lee, Eun Kyung Kim, Sook Tai Ha, Sung Nam Kim, Eun-Jung Park, Jong Jae Jung, Sun Hee Sung, Sung-chul Lim
J Pathol Transl Med. 2017;51(3):314-319.   Published online April 17, 2017
  • 8,903 View
  • 276 Download
  • 14 Citations
AbstractAbstract PDF
Cervical cytology for uterine cervical cancer screening has transitioned from conventional smear (CS) to liquid-based cytology (LBC), which has many advantages. The aim of this study was to compare the proportion of unsatisfactory specimens from CS versus LBC at multiple institutions including general hospitals and commercial laboratories.
Each participating institution provided a minimum of 500 Papanicolaou (Pap) test results for analysis. Pap tests were classified according to the participating institution (commercial laboratory or general hospital) and the processing method (CS, ThinPrep, SurePath, or CellPrep). The causes of unsatisfactory results were classified as technical problems, scant cellularity, or complete obscuring factors.
A total of 38,956 Pap test results from eight general hospitals and three commercial laboratories were analyzed. The mean unsatisfactory rate of LBC was significantly lower than that of CS (1.26% and 3.31%, p = .018). In the LBC method, samples from general hospitals had lower unsatisfactory rates than those from commercial laboratories (0.65% vs 2.89%, p = .006). The reasons for unsatisfactory results were heterogeneous in CS. On the other hand, 66.2% of unsatisfactory results in LBC were due to the scant cellularity.
Unsatisfactory rate of cervical cancer screening test results varies according to the institution and the processing method. LBC has a significantly lower unsatisfactory rate than CS.


Citations to this article as recorded by  
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    Lia Barrios, Yoled Vizcaíno, Ines Benedetti
    Journal of Cytology.2022;[Epub]     CrossRef
  • Meeting the challenges of cervical cancer screening and HPV vaccination in the UK
    Roxanne Westwood , Joanna Lavery
    Primary Health Care.2022; 32(1): 22.     CrossRef
  • Method for preservation of DNA stability of liquid-based cytology specimens from a lung adenocarcinoma cell line
    Yukiko Matsuo, Kazuya Yamashita, Tsutomu Yoshida, Yukitoshi Satoh
    Virchows Archiv.2021; 478(3): 507.     CrossRef
  • High-risk human papillomavirus test in anal smears: can it optimize the screening for anal cancer?
    Cintia M.S. Kimura, Caio S.R. Nahas, Edésio V. Silva-Filho, Vinícius L. Ribeiro, Aluisio C. Segurado, Flávio F.P. Alcântara, Ivan Cecconello, Sergio C. Nahas
    AIDS.2021; 35(5): 737.     CrossRef
  • Automatic model for cervical cancer screening based on convolutional neural network: a retrospective, multicohort, multicenter study
    Xiangyu Tan, Kexin Li, Jiucheng Zhang, Wenzhe Wang, Bian Wu, Jian Wu, Xiaoping Li, Xiaoyuan Huang
    Cancer Cell International.2021;[Epub]     CrossRef
  • The cytological component of cervical cancer screening: causes of false negative and false positive results, and ways to avoid them
    O.A. Burka, N.F. Lygyrda, V.V. Kutsovol, A.V. Svintsitska
    REPRODUCTIVE ENDOCRINOLOGY.2021; (57): 61.     CrossRef
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  • Characterizing the Effect of Automated Cell Sorting Solutions on Cytomorphological Changes
    Katsuhide Ikeda, Shouichi Sato, Hiroshi Chigira, Yasuo Shibuki, Nobuyoshi Hiraoka
    Acta Cytologica.2020; 64(3): 232.     CrossRef
  • Comparison between Conventional Cytology and Liquid-Based Cytology in the Tertiary Brazilian Navy Hospital in Rio de Janeiro
    Antônio Carlos Almeida de Oliveira, Miguel Fontes Domingues, Paulo Murilo Neufeld, Marcos Fleury, José Firmino Nogueira Neto
    Acta Cytologica.2020; 64(6): 539.     CrossRef
  • Follow‐up with histopathology and HPV testing on LSIL cytology in China’s largest academic woman’s hospital
    Xiang Tao, Huina Zhang, Hao Zhang, Jianan Xiao, Juan Li, Xianrong Zhou, Li Wang, Chengquan Zhao
    Cancer Cytopathology.2019; 127(4): 258.     CrossRef
  • Current Status of and Perspectives on Cervical Cancer Screening in Korea
    Sung-Chul Lim, Chong Woo Yoo
    Journal of Pathology and Translational Medicine.2019; 53(4): 210.     CrossRef
  • Reducing DNA damage by formaldehyde in liquid‐based cytology preservation solutions to enable the molecular testing of lung cancer specimens
    Yukiko Matsuo, Tsutomu Yoshida, Kazuya Yamashita, Yukitoshi Satoh
    Cancer Cytopathology.2018; 126(12): 1011.     CrossRef
  • Cervical Cancer Screening Programs in Europe: The Transition Towards HPV Vaccination and Population-Based HPV Testing
    Andreas Chrysostomou, Dora Stylianou, Anastasia Constantinidou, Leondios Kostrikis
    Viruses.2018; 10(12): 729.     CrossRef
Comparison of Diagnostic Cytomorphology of Atypical Squamous Cells in Liquid-Based Preparations and Conventional Smears
Jung Dal Lee, Young-Ha Oh, Seong Ok Lee, Jong Yull Kim
Korean J Pathol. 2012;46(4):365-369.   Published online August 23, 2012
  • 8,949 View
  • 62 Download
  • 3 Citations
AbstractAbstract PDF

The aims of this study were to compare the cytomorphologic features diagnostic of atypical squamous cells (ASC) in liquid-based preparations (LBPs) and conventional Pap (CP) smears and to cytomorphologically assess the performance of the Cell Scan 1500™ in cervical cytology practice.


Cervicovaginal smears were obtained from 938 women. Two smears were obtained simultaneously from each individual, one for an LBP and the other for a CP smear; the smears were independently examined. ASC was diagnosed in 24 patients, and their samples were cytomorphologically and semiquantitatively analyzed.


A total of 24 of the 938 women (2.6%) were diagnosed with ASC by one or both methods. Results from LBPs and CP smears were in agreement in 13 of 24 cases of ASC diagnosis (absolute direct agreement, 54.2%; k<0.20; p-value from chi-square test=0.085). Diagnostic features of ASC in the LBPs included squamous cell atypia and atypical squamous metaplasia.


The cellular features diagnostic of ASC present in one preparation can manifest themselves differently in the other. Changes in individual cells, particularly nuclear changes, are the most reliable features for diagnosing ASC. The Cell Scan 1500™ processor is more effective at detecting ASC than are CP smears.


Citations to this article as recorded by  
  • Risikobewertung von Zytologiebefunden im Zervixkarzinom-Screening
    Katrin Marquardt, Peter Ziemke, Konrad Neumann, Wolfgang Kühn
    Der Gynäkologe.2019; 52(12): 937.     CrossRef
  • Nationwide cervical cancer screening in Korea: data from the National Health Insurance Service Cancer Screening Program and National Cancer Screening Program, 2009–2014
    Seung-Hyuk Shim, Hyeongsu Kim, In-Sook Sohn, Han-Sung Hwang, Han-Sung Kwon, Sun Joo Lee, Ji Young Lee, Soo-Nyung Kim, Kunsei Lee, Sounghoon Chang
    Journal of Gynecologic Oncology.2017;[Epub]     CrossRef
  • Morphologic Analysis of Cytomegalovirus Infected Cells in Bronchial Washing Cytology: Comparison of Liquid-Based Preparation and Conventional Smear
    Jae Yeon Seok, Jungsuk An, Seung Yeon Ha, Dong Hae Chung, Sangho Lee, Hyunchul Kim
    Journal of Pathology and Translational Medicine.2016; 50(2): 147.     CrossRef

JPTM : Journal of Pathology and Translational Medicine