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2 "Cervical cytology"
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Comparison of Unsatisfactory Samples from Conventional Smear versus Liquid-Based Cytology in Uterine Cervical Cancer Screening Test
Hoiseon Jeong, Sung Ran Hong, Seoung-Wan Chae, So-Young Jin, Hye Kyoung Yoon, Juhie Lee, Eun Kyung Kim, Sook Tai Ha, Sung Nam Kim, Eun-Jung Park, Jong Jae Jung, Sun Hee Sung, Sung-chul Lim
J Pathol Transl Med. 2017;51(3):314-319.   Published online April 17, 2017
DOI: https://doi.org/10.4132/jptm.2017.03.17
  • 8,903 View
  • 276 Download
  • 14 Citations
AbstractAbstract PDF
Background
Cervical cytology for uterine cervical cancer screening has transitioned from conventional smear (CS) to liquid-based cytology (LBC), which has many advantages. The aim of this study was to compare the proportion of unsatisfactory specimens from CS versus LBC at multiple institutions including general hospitals and commercial laboratories.
Methods
Each participating institution provided a minimum of 500 Papanicolaou (Pap) test results for analysis. Pap tests were classified according to the participating institution (commercial laboratory or general hospital) and the processing method (CS, ThinPrep, SurePath, or CellPrep). The causes of unsatisfactory results were classified as technical problems, scant cellularity, or complete obscuring factors.
Results
A total of 38,956 Pap test results from eight general hospitals and three commercial laboratories were analyzed. The mean unsatisfactory rate of LBC was significantly lower than that of CS (1.26% and 3.31%, p = .018). In the LBC method, samples from general hospitals had lower unsatisfactory rates than those from commercial laboratories (0.65% vs 2.89%, p = .006). The reasons for unsatisfactory results were heterogeneous in CS. On the other hand, 66.2% of unsatisfactory results in LBC were due to the scant cellularity.
Conclusions
Unsatisfactory rate of cervical cancer screening test results varies according to the institution and the processing method. LBC has a significantly lower unsatisfactory rate than CS.

Citations

Citations to this article as recorded by  
  • Liquid-Based cytology in the detection of premalignant lesions in patients with “atypia in squamous cells” in conventional cytology
    Lia Barrios, Yoled Vizcaíno, Ines Benedetti
    Journal of Cytology.2022;[Epub]     CrossRef
  • Meeting the challenges of cervical cancer screening and HPV vaccination in the UK
    Roxanne Westwood , Joanna Lavery
    Primary Health Care.2022; 32(1): 22.     CrossRef
  • Method for preservation of DNA stability of liquid-based cytology specimens from a lung adenocarcinoma cell line
    Yukiko Matsuo, Kazuya Yamashita, Tsutomu Yoshida, Yukitoshi Satoh
    Virchows Archiv.2021; 478(3): 507.     CrossRef
  • High-risk human papillomavirus test in anal smears: can it optimize the screening for anal cancer?
    Cintia M.S. Kimura, Caio S.R. Nahas, Edésio V. Silva-Filho, Vinícius L. Ribeiro, Aluisio C. Segurado, Flávio F.P. Alcântara, Ivan Cecconello, Sergio C. Nahas
    AIDS.2021; 35(5): 737.     CrossRef
  • Automatic model for cervical cancer screening based on convolutional neural network: a retrospective, multicohort, multicenter study
    Xiangyu Tan, Kexin Li, Jiucheng Zhang, Wenzhe Wang, Bian Wu, Jian Wu, Xiaoping Li, Xiaoyuan Huang
    Cancer Cell International.2021;[Epub]     CrossRef
  • The cytological component of cervical cancer screening: causes of false negative and false positive results, and ways to avoid them
    O.A. Burka, N.F. Lygyrda, V.V. Kutsovol, A.V. Svintsitska
    REPRODUCTIVE ENDOCRINOLOGY.2021; (57): 61.     CrossRef
  • Comparison of liquid-based cytology with conventional smear cytology for EUS-guided FNA of solid pancreatic masses: a prospective randomized noninferiority study
    Jung Won Chun, Kyoungbun Lee, Sang Hyub Lee, Haeryoung Kim, Min Su You, Yoon Jung Hwang, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim
    Gastrointestinal Endoscopy.2020; 91(4): 837.     CrossRef
  • Effective reduction in inadequate Pap smears by using a saline-lubricated speculum and two glass slides
    Chi-Jui Chen, Mun-Kun Hong, Dah-Ching Ding
    Taiwanese Journal of Obstetrics and Gynecology.2020; 59(6): 906.     CrossRef
  • Characterizing the Effect of Automated Cell Sorting Solutions on Cytomorphological Changes
    Katsuhide Ikeda, Shouichi Sato, Hiroshi Chigira, Yasuo Shibuki, Nobuyoshi Hiraoka
    Acta Cytologica.2020; 64(3): 232.     CrossRef
  • Comparison between Conventional Cytology and Liquid-Based Cytology in the Tertiary Brazilian Navy Hospital in Rio de Janeiro
    Antônio Carlos Almeida de Oliveira, Miguel Fontes Domingues, Paulo Murilo Neufeld, Marcos Fleury, José Firmino Nogueira Neto
    Acta Cytologica.2020; 64(6): 539.     CrossRef
  • Follow‐up with histopathology and HPV testing on LSIL cytology in China’s largest academic woman’s hospital
    Xiang Tao, Huina Zhang, Hao Zhang, Jianan Xiao, Juan Li, Xianrong Zhou, Li Wang, Chengquan Zhao
    Cancer Cytopathology.2019; 127(4): 258.     CrossRef
  • Current Status of and Perspectives on Cervical Cancer Screening in Korea
    Sung-Chul Lim, Chong Woo Yoo
    Journal of Pathology and Translational Medicine.2019; 53(4): 210.     CrossRef
  • Reducing DNA damage by formaldehyde in liquid‐based cytology preservation solutions to enable the molecular testing of lung cancer specimens
    Yukiko Matsuo, Tsutomu Yoshida, Kazuya Yamashita, Yukitoshi Satoh
    Cancer Cytopathology.2018; 126(12): 1011.     CrossRef
  • Cervical Cancer Screening Programs in Europe: The Transition Towards HPV Vaccination and Population-Based HPV Testing
    Andreas Chrysostomou, Dora Stylianou, Anastasia Constantinidou, Leondios Kostrikis
    Viruses.2018; 10(12): 729.     CrossRef
Cytomorphologic Features According to HPV DNA Type in Histologically Proven Cases of the Uterine Cervix.
In Ho Choi, So Young Jin, Dong Wha Lee, Dong Won Kim, Yoon Mi Jeen
Korean J Pathol. 2011;45(6):612-620.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.612
  • 3,083 View
  • 23 Download
  • 4 Citations
AbstractAbstract PDF
BACKGROUND
This study investigated whether human papillomavirus (HPV) genotype is related to koilocytic changes in cervical cytology and histology, and what factors cause discrepancies among cytology, HPV DNA chip tests, and biopsies.
METHODS
We examined 174 of 949 cases histologically confirmed by both cytology and HPV DNA chip testing. We analyzed koilocytic changes in cytology and biopsies according to HPV genotype.
RESULTS
HPV-16 significantly coincided with nuclear size variation and hyperchromasia, although the cytomorphologic features correlated with other HPV genotypes were not statistically significant. By analyzing 68 cases in which there were discrepancies between the HPV DNA chip test and histological results, we confirmed that artifacts or glycogen acanthosis resulted in the over-diagnoses of four HPV-negative cases with normal cytology. Four diagnostic errors and four sampling errors were present in eight HPV-positive cases. The degree of nuclear size variation significantly influenced the cytologically under-diagnosed cases (p=0.006).
CONCLUSIONS
Other than HPV-16, HPV genotype exhibited no cytological or histological differences. The discrepancy between the results of HPV DNA chip test and histology was created by glycogen acanthosis, immature squamous metaplasia, artifacts, and sampling errors.

Citations

Citations to this article as recorded by  
  • Koilocytic changes are not elicited by human papillomavirus genotypes with higher oncogenic potential
    Mitsuaki Okodo, Kaori Okayama, Koji Teruya, Hirokazu Kimura, Natsumi Noji, Yasuyoshi Ishii, Masahiko Fujii, Mizue Oda, Toshiyuki Sasagawa
    Journal of Medical Virology.2020; 92(12): 3766.     CrossRef
  • Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea
    Youn Jin Choi, Eun Young Ki, Chuqing Zhang, Wendy C. S. Ho, Sung-Jong Lee, Min Jin Jeong, Paul K. S. Chan, Jong Sup Park, Xuefeng Liu
    PLOS ONE.2016; 11(12): e0168178.     CrossRef
  • Uncommon and Rare Human Papillomavirus Genotypes Relating to Cervical Carcinomas
    Na Rae Kim, Myunghee Kang, Soon Pyo Lee, Hyunchul Kim, Jungsuk An, Dong Hae Chung, Seung Yeon Ha, Hyun Yee Cho
    Korean Journal of Pathology.2014; 48(1): 43.     CrossRef
  • Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia
    Tae Eun Kim, Hwal Woong Kim, Kyung Eun Lee
    Korean Journal of Pathology.2014; 48(1): 24.     CrossRef

JPTM : Journal of Pathology and Translational Medicine