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- Clinicopathological characteristics of BRCA-associated breast cancer in Asian patients
- Eun-Kyu Kim, So Yeon Park, Sung-Won Kim
- J Pathol Transl Med. 2020;54(4):265-275. Published online May 14, 2020
- DOI: https://doi.org/10.4132/jptm.2020.04.07
- 6,211 View
- 224 Download
- 11 Web of Science
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Abstract
PDF BRCA 1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of theBRCA genes, several attempts have been made to define the clinicopathological characteristics ofBRCA -associated breast cancer in comparison with sporadic breast cancer. Asians constitute 60% of the world population, and although the incidence of breast cancer in Asia remains low compared to the West, breast cancer is the most prevalent female cancer in the region. The epidemiological aspects of breast cancer are different between Asians and Caucasians. Asian patients present with breast cancer at a younger age than Western patients. The contributions ofBRCA1/2 mutations to breast cancer incidence are expected to differ between Asians and Caucasians, and the different genetic backgrounds among races are likely to influence the breast cancer phenotypes. However, most large-scale studies on the clinicopathological characteristics ofBRCA -associated breast cancer have been on Western patients, while studies on Asian populations were small and sporadic. In this review, we provide an overview of the clinical and pathological characteristics ofBRCA -associated breast cancer, incorporating findings on Asian patients.-
Citations
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- Characteristics of breast cancer patients tested for germline BRCA1/2 mutations by next‐generation sequencing in Ramathibodi Hospital, Mahidol University
Songporn Oranratnachai, Watchalawalee Yamkaew, Atchara Tunteeratum, Thongchai Sukarayothin, Nareenart Iemwimangsa, Ravat Panvichien
Cancer Reports.2023;[Epub] CrossRef - Prognostic and predictive biomarkers with therapeutic targets in breast cancer: A 2022 update on current developments, evidence, and recommendations
Clement Chung, Vanessa T.Y. Yeung, Kenneth C.W. Wong
Journal of Oncology Pharmacy Practice.2023; 29(6): 1343. CrossRef - Mutations of TP53 and genes related to homologous recombination repair in breast cancer with germline BRCA1/2 mutations
Jinyong Kim, Kyeonghun Jeong, Hyeji Jun, Kwangsoo Kim, Jeong Mo Bae, Myung Geun Song, Hanbaek Yi, Songyi Park, Go-un Woo, Dae-Won Lee, Tae-Yong Kim, Kyung-Hun Lee, Seock-Ah Im
Human Genomics.2023;[Epub] CrossRef - BRCA 1–2 Incidence in Synchronous and Metachronous Breast Cancer: a Tertiary Center Study
Ahmet Dağ, Bilal Arslan, Erkan Güler, Serdar Mermer
Indian Journal of Surgery.2022;[Epub] CrossRef - Habitat Analysis of Breast Cancer-Enhanced MRI Reflects BRCA1 Mutation Determined by Immunohistochemistry
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BioMed Research International.2022; 2022: 1. CrossRef - Prevalence and Factors Associated with BRCA1/2 Gene Mutation in Chinese Populations with Breast Cancer
Guoding Huang, Hongquan Lu, Qizhu Chen, Xinting Huang
International Journal of General Medicine.2022; Volume 15: 6783. CrossRef - Association between fertility treatments and breast cancer risk in women with a family history or BRCA mutations: a systematic review and meta-analysis
Xiaojing Liu, Jing Yue, Ruqiya Pervaiz, Hanwang Zhang, Lan Wang
Frontiers in Endocrinology.2022;[Epub] CrossRef - Relationship between Baseline [18F]FDG PET/CT Semiquantitative Parameters and BRCA Mutational Status and Their Prognostic Role in Patients with Invasive Ductal Breast Carcinoma
Francesco Dondi, Domenico Albano, Pietro Bellini, Luca Camoni, Giorgio Treglia, Francesco Bertagna
Tomography.2022; 8(6): 2662. CrossRef - The clinical and diagnostic characteristics of BRCA-associated breast cancer
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Onkologiya. Zhurnal imeni P.A.Gertsena.2022; 11(6): 18. CrossRef - The Clinical and Pathological Profile of BRCA1 Gene Methylated Breast Cancer Women: A Meta-Analysis
Ilary Ruscito, Maria Luisa Gasparri, Maria Paola De Marco, Flavia Costanzi, Aris Raad Besharat, Andrea Papadia, Thorsten Kuehn, Oreste Davide Gentilini, Filippo Bellati, Donatella Caserta
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International Journal of General Medicine.2021; Volume 14: 7371. CrossRef
- Characteristics of breast cancer patients tested for germline BRCA1/2 mutations by next‐generation sequencing in Ramathibodi Hospital, Mahidol University
Original Article
- Allelic Loss at the BRCA1 and BRCA2 Loci in Sporadic Breast Carcinoma Using Paraffin Embedded Tissue .
- Ji Young Park, Myung Hoon Lee, Dong Ja Kim, Tae In Park, Young Ha Lee, Jung Wan Kim, Yoon Kyung Sohn
- Korean J Pathol. 2002;36(2):100-105.
- 1,557 View
- 14 Download
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Abstract
PDF
- BACKGROUND
Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer susceptibility and a lifetime risk of breast. Several morphological and clinical features have been attributed to hereditary tumors. However, in sporadic breast cancer, the interrelationship between the loss of heterozygosity (LOH) of these loci and clinical features remains to be fully elucidated.
METHODS
Microdissected paraffin-embedded tissue blocks of 48 cases of surgically resected breast carcinoma were investigated to identify the LOH of BRCA1 and BRCA2 using microsatellite markers.
RESULTS
Of 48 cases, 22 (45.9%) exhibited LOH at BRCA1 locus while in 29 out of 48 (60.4%) cases LOH was observed for the BRCA2 region. There was no significant correlation between LOH at BRCA1/2 and the patient's age, tumor size, histologic grade or lymph node metastasis. When comparing the frequency of LOH with the expression of several prognostic factors, such as p53, c-erb B2 protein, estrogen and progesterone receptor using immunohistochemical stain, there was only correlation with LOH at BRCA2 and the progesterone receptor.
CONCLUSIONS
Our results suggest that allelic deletion play a role to the development of sporadic breast cancers.
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