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3 "Eun Ji Oh"
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Current Cytology Practices in Korea: A Nationwide Survey by the Korean Society for Cytopathology
Eun Ji Oh, Chan Kwon Jung, Dong-Hoon Kim, Han Kyeom Kim, Wan Seop Kim, So-Young Jin, Hye Kyoung Yoon
J Pathol Transl Med. 2017;51(6):579-587.   Published online September 27, 2017
  • 6,158 View
  • 151 Download
  • 12 Citations
AbstractAbstract PDF
Limited data are available on the current status of cytology practices in Korea. This nationwide study presents Korean cytology statistics from 2015.
A nationwide survey was conducted in 2016 as a part of the mandatory quality-control program by the Korean Society for Cytopathology. The questionnaire was sent to 208 medical institutions performing cytopathologic examinations in Korea. Individual institutions were asked to submit their annual cytology statistical reports and gynecologic cytology-histology correlation data for 2015.
Responses were obtained from 206 medical institutions including 83 university hospitals, 87 general hospitals, and 36 commercial laboratories. A total of 8,284,952 cytologic examinations were performed in 2015, primarily in commercial laboratories (74.9%). The most common cytology specimens were gynecologic samples (81.3%). Conventional smears and liquid-based cytology were performed in 6,190,526 (74.7%) and 2,094,426 (25.3%) cases, respectively. The overall diagnostic concordance rate between cytologic and histologic diagnoses of uterine cervical samples was 70.5%. Discordant cases were classified into three categories: category A (minimal clinical impact, 17.4%), category B (moderate clinical impact, 10.2%), and category C (major clinical impact, 1.9%). The ratio of atypical squamous cells of undetermined significance to squamous intraepithelial lesion was 1.6 in university hospitals, 2.9 in general hospitals, and 4.9 in commercial laboratories.
This survey reveals the current status and trend of cytology practices in Korea. The results of this study can serve as basic data for the establishment of nationwide cytopathology policies and quality improvement guidelines in Korean medical institutions.


Citations to this article as recorded by  
  • Current state of cytopathology residency training: a Korean national survey of pathologists
    Uiju Cho, Tae Jung Kim, Wan Seop Kim, Kyo Young Lee, Hye Kyoung Yoon, Hyun Joo Choi
    Journal of Pathology and Translational Medicine.2023; 57(2): 95.     CrossRef
  • Recent Application of Artificial Intelligence in Non-Gynecological Cancer Cytopathology: A Systematic Review
    Nishant Thakur, Mohammad Rizwan Alam, Jamshid Abdul-Ghafar, Yosep Chong
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  • Re-Increasing Trends in Thyroid Cancer Incidence after a Short Period of Decrease in Korea: Reigniting the Debate on Ultrasound Screening
    Chan Kwon Jung, Ja Seong Bae, Young Joo Park
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  • Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study
    Jung-A Sung, Ilias P. Nikas, Haeryoung Kim, Han Suk Ryu, Cheol Lee
    Journal of Pathology and Translational Medicine.2022; 56(6): 354.     CrossRef
  • Current status of cytopathology practice in Korea: impact of the coronavirus pandemic on cytopathology practice
    Soon Auck Hong, Haeyoen Jung, Sung Sun Kim, Min-Sun Jin, Jung-Soo Pyo, Ji Yun Jeong, Younghee Choi, Gyungyub Gong, Yosep Chong
    Journal of Pathology and Translational Medicine.2022; 56(6): 361.     CrossRef
  • Systematic screening for cervical cancer in Dakar region: prevalence and correlation with biological and socio-demographic parameters
    Dominique Diouf, Gora Diop, Cheikh Ahmadou Tidian Diarra, Aminata Issa Ngom, Khadija Niane, Moussa Ndiaye, Sidy Ka, Oumar Faye, Ahmadou Dem
    Infectious Agents and Cancer.2020;[Epub]     CrossRef
  • Continuous quality improvement program and its results of Korean Society for Cytopathology
    Yoo-Duk Choi, Hoon-Kyu Oh, Su-Jin Kim, Kyung-Hee Kim, Yun-Kyung Lee, Bo-Sung Kim, Eun-Jeong Jang, Yoon-Jung Choi, Eun-Kyung Han, Dong-Hoon Kim, Younghee Choi, Chan-Kwon Jung, Sung-Nam Kim, Kyueng-Whan Min, Seok-Jin Yoon, Hun-Kyung Lee, Kyung Un Choi, Hye
    Journal of Pathology and Translational Medicine.2020; 54(3): 246.     CrossRef
  • Current status of cytopathology practices in Korea: annual report on the Continuous Quality Improvement program of the Korean Society for Cytopathology for 2018
    Yosep Chong, Haeyoen Jung, Jung-Soo Pyo, Soon Won Hong, Hoon Kyu Oh
    Journal of Pathology and Translational Medicine.2020; 54(4): 318.     CrossRef
  • Current Status of and Perspectives on Cervical Cancer Screening in Korea
    Sung-Chul Lim, Chong Woo Yoo
    Journal of Pathology and Translational Medicine.2019; 53(4): 210.     CrossRef
  • Cytomorphological Features of Hyperchromatic Crowded Groups in Liquid-Based Cervicovaginal Cytology: A Single Institutional Experience
    Youngeun Lee, Cheol Lee, In Ae Park, Hyoung Jin An, Haeryoung Kim
    Journal of Pathology and Translational Medicine.2019; 53(6): 393.     CrossRef
  • Comparison Study of the Adequacy and Pain Scale of Ultrasound-Guided Fine-Needle Aspiration of Solid Thyroid Nodules with a 21- or 23-Gauge Needle for Liquid-Based Cytology: a Single-Center Study
    Soo Jin Jung, Dong Wook Kim, Hye Jin Baek
    Endocrine Pathology.2018; 29(1): 30.     CrossRef
  • Thyroid Fine-Needle Aspiration Cytology Practice in Korea
    Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
    Journal of Pathology and Translational Medicine.2017; 51(6): 521.     CrossRef
Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation
Eun Ji Oh, Soo Hee Kim, Woo Ick Yang, Young Hyeh Ko, Sun Och Yoon
J Pathol Transl Med. 2016;50(5):369-376.   Published online August 22, 2016
  • 7,589 View
  • 166 Download
  • 22 Citations
AbstractAbstract PDF
A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and EED) that induce histone H3 trimethylation at lysine 27 (H3K27me3). Deregulation of c-MYC and interaction between c-MYC and EZH2 are well known in lymphomagenesis; however, little is known about the expression status of HOTAIR in diffuse large B-cell lymphomas (DLBCLs).
The expression status of PRC2 (EZH2, SUZ12, and EED), H3K27me3, c-MYC, and BCL2 was analyzed using immunohistochemistry (n = 231), and HOTAIR was investigated by a quantification real-time polymerase chain reaction method (n = 164) in DLBCLs.
The present study confirmed the positive correlation among PRC2 proteins, H3K27me3, and c-MYC in DLBCLs. Expression level of HOTAIR was also positively correlated to EZH2 (p < .05, respectively). Between c-MYC and HOTAIR, and between c- MYC/BCL2 co-expression and HOTAIR, however, negative correlation was observed in DLBCLs (p < .05, respectively). High level of H3K27me3 was determined as an independent prognostic marker in poor overall survival (hazard ratio, 2.0; p = .023) of DLBCL patients. High expression of HOTAIR, however, was associated with favorable overall survival (p = .004) in the univariate analysis, but the impact was not significant in the multivariate analysis. The favorable outcome of DLBCL with HOTAIR high expression levels may be related to the negative correlation with c- MYC expression or c-MYC/BCL2 co-expression.
HOTAIR expression could be one of possible mechanisms for inducing H3K27me3 via EZH2-related PRC2 activation, and induced H3K27me3 may be strongly related to aggressive DLBCLs which show poor patient outcome.


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    Non-coding RNA Research.2022; 7(3): 184.     CrossRef
  • Biomedical impact of the expression of HOX locus-associated LncRNAs HOTAIR and HOTTIP in diffuse large B cell lymphoma
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    Human Gene.2022; 34: 201112.     CrossRef
  • Mechanism of LncHOTAIR Regulating Proliferation, Apoptosis, and Autophagy of Lymphoma Cells through hsa-miR-6511b-5p/ATG7 Axis
    Fu Gui, Xinyi Yu, Yemeng Wu, Chao Wu, Yulan Zhang, Peng-Yue Zhang
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Circulating RNA biomarkers in diffuse large B-cell lymphoma: a systematic review
    Philippe Decruyenaere, Fritz Offner, Jo Vandesompele
    Experimental Hematology & Oncology.2021;[Epub]     CrossRef
  • Circulating long non-coding RNAs HOTAIR, Linc-p21, GAS5 and XIST expression profiles in diffuse large B-cell lymphoma: association with R-CHOP responsiveness
    Mahmoud A. Senousy, Aya M. El-Abd, Raafat R. Abdel-Malek, Sherine M. Rizk
    Scientific Reports.2021;[Epub]     CrossRef
  • An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells
    Krishnapriya M. Varier, Hemavathi Dhandapani, Wuling Liu, Jialei Song, Chunlin Wang, Anling Hu, Yaacov Ben-David, Xiangchun Shen, Yanmei Li, Babu Gajendran
    Journal of Experimental & Clinical Cancer Research.2021;[Epub]     CrossRef
  • Cancer‑associated fibroblast‑derived CCL5 contributes to cisplatin resistance in A549 NSCLC cells partially through upregulation of lncRNA HOTAIR expression
    Xiangjun Sun, Zhijie Chen
    Oncology Letters.2021;[Epub]     CrossRef
  • Competitive Endogenous RNA Network Involving miRNA and lncRNA in Non-Hodgkin Lymphoma: Current Advances and Clinical Perspectives
    Mara Fernandes, Herlander Marques, Ana Luísa Teixeira, Rui Medeiros
    Biomedicines.2021; 9(12): 1934.     CrossRef
  • EZH2 expression is dependent on MYC and TP53 regulation in diffuse large B‐cell lymphoma
    Eduardo Henrique Neves Filho, Carlos Gustavo Hirth, Igor Allen Frederico, Rommel Mario Burbano, Thiago Carneiro, Silvia Helena Rabenhorst
    APMIS.2020; 128(4): 308.     CrossRef
  • Long Noncoding RNAs in Diffuse Large B-Cell Lymphoma: Current Advances and Perspectives

    Xianbo Huang, Wenbin Qian, Xiujin Ye
    OncoTargets and Therapy.2020; Volume 13: 4295.     CrossRef
  • Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC
    Chen-Chen Zhao, Yang Jiao, Yi-Yin Zhang, Jie Ning, Yi-Ruo Zhang, Jing Xu, Wei Wei, Gu Kang-Sheng
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  • H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
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  • HOTAIR as a Prognostic Predictor for Diverse Human Cancers: A Meta- and Bioinformatics Analysis
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    Cancers.2019; 11(6): 778.     CrossRef
  • Long Noncoding RNA HOTAIR Promotes Endometrial Carcinoma Cell Proliferation by Binding to PTEN via the Activating Phosphatidylinositol 3-Kinase/Akt Signaling Pathway
    Xiao-Hui Zhang, Pin Hu, Yang-Qin Xie, Yong-Jun Kang, Min Li
    Molecular and Cellular Biology.2019;[Epub]     CrossRef
  • EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications
    Boheng Li, Wee-Joo Chng
    Journal of Hematology & Oncology.2019;[Epub]     CrossRef
  • The prognostic impact of long noncoding RNA HOTAIR in leukemia and lymphoma: a meta-analysis
    Yun Lin, Zhihong Fang, Zhijuan Lin, Zhifeng Li, Jintao Zhao, Yiming Luo, Bing Xu
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  • Retracted: Downregulation of Long Noncoding RNA HOTAIR and EZH2 Induces Apoptosis and Inhibits Proliferation, Invasion, and Migration of Human Breast Cancer Cells
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  • Long Non-Coding RNAs Guide the Fine-Tuning of Gene Regulation in B-Cell Development and Malignancy
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  • HOTAIR , a long noncoding RNA , is a marker of abnormal cell cycle regulation in lung cancer
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Diagnostic Accuracy of Cerebrospinal Fluid (CSF) Cytology in Metastatic Tumors: An Analysis of Consecutive CSF Samples
Yoon Sung Bae, June-Won Cheong, Won Seok Chang, Sewha Kim, Eun Ji Oh, Se Hoon Kim
Korean J Pathol. 2013;47(6):563-568.   Published online December 24, 2013
  • 5,775 View
  • 33 Download
  • 8 Citations
AbstractAbstract PDF

Cerebrospinal fluid (CSF) examination can be used to verify the presence of primary malignancies as well as cases of central nervous system (CNS) metastasis. Because of its importance, there have been several studies concerning the sensitivity of CSF cytology. To determine the practical use and reproducibility of diagnoses based on CSF cytology, we evaluated this test by analyzing cytology results from consecutive CSF samples.


Between July 2010 and June 2013, 385 CSF cytology samples from 42 patients were collected. The samples were gathered using a ventricular catheter and reservoir. CSF cytology of all patients was examined more than two times with immunocytochemistry for cytokeratin.


Primary neoplastic sites and histologic types of patients' metastatic cancer were diverse. The overall sensitivity for detecting malignancy was 41.3%. Even within short-term intervals, diagnoses frequently changed.


Our results were inconsistent, with low sensitivity, when compared to the results of previous studies. However, CSF evaluation can still provide valuable diagnostic and prognostic information because adjuvant treatments are now routinely performed in patients with CNS metastasis. Negative CSF cytology results should not be ignored, and continuous CSF follow-up is essential for following the clinical course of patients with metastatic cancer involving the CNS.


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JPTM : Journal of Pathology and Translational Medicine