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- Cervical intraepithelial neoplasia and cervical cytology in pregnancy
- Ji-Young Kim, Jeong Yun Shim
- J Pathol Transl Med. 2024;58(6):283-290. Published online November 7, 2024
- DOI: https://doi.org/10.4132/jptm.2024.10.17
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- 543 Download
- 4 Web of Science
- 6 Crossref
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Abstract
PDF - Cervical cancer screening during pregnancy presents unique challenges for cytologic interpretation. This review focuses on pregnancy-associated cytomorphological changes and their impact on diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer. Pregnancy-induced alterations include navicular cells, hyperplastic endocervical cells, immature metaplastic cells, and occasional decidual cells or trophoblasts. These changes can mimic abnormalities such as koilocytosis, adenocarcinoma in situ, and high-grade squamous intraepithelial lesions, potentially leading to misdiagnosis. Careful attention to nuclear features and awareness of pregnancy-related changes are crucial for correct interpretation. The natural history of CIN during pregnancy shows higher regression rates, particularly for CIN 2, with minimal risk of progression. Management of abnormal cytology follows modified risk-based guidelines to avoid invasive procedures, with treatment typically deferred until postpartum. The findings reported in this review emphasize the importance of considering pregnancy status in cytological interpretation, highlight potential problems, and provide guidance on differentiating benign pregnancy-related changes from true abnormalities. Understanding these nuances is essential for accurate diagnosis and proper management of cervical abnormalities in pregnant women.
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Citations
Citations to this article as recorded by
- HPV in Pregnancy: Implications for Screening, Vaccination, and Maternal–Fetal Health
Suman Kumar, Swati, Swati Salila, Akanksha Raj, Pratima Gupta, Neha Sharad, Nidhi Chaudhary
Journal of Pregnancy.2026;[Epub] CrossRef - Approaches to Intraepithelial Cervical Neoplasia Management in Pregnancy: A Narrative Review
Delia-Maria Bogheanu, Awatif Jaafar Sadeq Al Bayati, Mircea-Octavian Poenaru, Octavian Gabriel Olaru, Gabriel-Petre Gorecki, Andreea Gratiana Boiangiu, Bashar Haj Hamoud, Romina-Marina Sima, Liana Ples
Life.2026; 16(5): 809. CrossRef - From treatment to trauma: Womens lived experiences of adverse pregnancy outcomes following cervical intraepithelial neoplasia treatment in Zambia
Mwiinga-Kalusopa Victoria, E. Maree Johanna, N. Kwaleyela Concepta, Uwamahoro Marie-Claire, Mwila Musenge Emmanuel, Anila Nkhata Loveness, Katowa-Mukwato Patricia
International Journal of Nursing and Midwifery.2026; 18(2): 14. CrossRef - Cervical Cytological Findings and Vaginal Microbiota Alterations During Pregnancy: A Retrospective Analysis
Federica Cianfrini, Antonio d’Amati, Clelia Molinario, Belen Padial Urteta, Chiara Boccaccini, Antonio Benedetto Maria Donateo, Antonietta Vella, Rosaria Santangelo, Rosa Pasqualina De Vincenzo, Angela Santoro, Gian Franco Zannoni
Sage Open Pathology.2026;[Epub] CrossRef - The significance of biological samples from pregnant women in cervical intraepithelial neoplasia
Xue Mi, Maharjan Rashmi, Zangyu Pan, Di Wu, Jinwei Miao
Frontiers in Medicine.2025;[Epub] CrossRef - Oncologic and pregnancy outcomes of cervical high-grade intraepithelial lesions and delivery mode
Olga P. Matylevich, Ilya A. Tarasau, Sviatlana Y. Shelkovich, Aliaksandr F. Martsinkevich
Academia Oncology.2025;[Epub] CrossRef
- HPV in Pregnancy: Implications for Screening, Vaccination, and Maternal–Fetal Health
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