Journal of Pathology and Translational Medicine

Brief Case Report

Placental Mesenchymal Dysplasia with Fetal Gastroschisis: Binnari Kim, Jiyeon Hyeon, Minju Lee, Hyewon Hwang, Yooju Shin, Suk-Joo Choi, Jung-Sun Kim; J Pathol Transl Med. 2015;49(1):71-74. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.12.14

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Diagnostic Accuracy of the Partograph Alert and Action Lines to Predict Adverse Birth Outcomes: A Systematic Review
M. Bonet, O. T. Oladapo, J. P. Souza, A. M. Gülmezoglu
Obstetrical & Gynecological Survey.2020; 75(5): 269. CrossRef
Placental Mesenchymal Dysplasia
Linda M. Ernst
Journal of Fetal Medicine.2015; 02(03): 127. CrossRef

Original Article

PHH3 as an Ancillary Mitotic Marker in Gastrointestinal Stromal Tumors: Yooju Shin, Jiyeon Hyeon, Boram Lee, Sang Yun Ha, Min Eui Hong, In Gu Do, Kyoung-Mee Kim; J Pathol Transl Med. 2015;49(1):23-29. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.10.08

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Background
Counting mitoses is subjective and time-consuming. The adjunctive diagnostic utility of a recently reported mitotic marker, phosphohistone H3 (PHH3), was investigated in gastrointestinal stromal tumors (GISTs). Methods: We reviewed 77 GISTs for several proliferative indices. These included the mitotic count per 50 high power fields (HPFs), the immunohistochemical Ki- 67 labeling index and the immunohistochemical PHH3 mitotic index (MI). For comparison, Spearman’s rank correlation and interclass correlation coefficient were used. Results: Mitotic counts ranged from 0–138 (mean, 7.57±2.34) and the PHH3 MI ranged from 0–126 per 50 HPFs (mean, 9.61±2.27). We found a positive correlation between mitotic counts and PHH3 MI (r=0.810, p<.001). The inter-observer correlation coefficient for three participants was 0.975 for mitotic counts and 0.940 for the PHH3 MI. When using the PHH3 MI instead of mitotic counts in the Armed Forces Institute of Pathology (AFIP) stratification criteria, 10 cases were reclassified. In one patient with a mitotic count of 2 and a PHH3 MI of 6 per 50 HPFs, distant metastasis occurred. Conclusions: In GISTs, the PHH3 MI correlated adequately with mitotic counts and can be used as a useful adjunctive to count mitotic figures efficiently.

Citations

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Potential of Proliferative Markers in Pancreatic Cancer Management: A Systematic Review
Aryan Salahi‐Niri, Paniz Zarand, Negar Mansouri, Parvaneh Rastgou, Omid Yazdani, Romina Esbati, Fatemeh Shojaeian, Behnaz Jahanbin, Zhaleh Mohsenifar, Hamid Asadzadeh Aghdaei, Farid Azmoudeh Ardalan, Seyed Amir Ahmad Safavi‐Naini
Health Science Reports.2025;[Epub] CrossRef
A retrospective study on expression and clinical significance of PHH3, Ki67 and P53 in bladder exophytic papillary urothelial neoplasms
Gaoxiu Qi, Jinmeng Liu, Shuqi Tao, Wenyuan Fan, Haoning Zheng, Meihong Wang, Hanchao Yang, Yongting Liu, Huancai Liu, Fenghua Zhou
PeerJ.2023; 11: e15675. CrossRef
Loss of Slfn3 induces a sex-dependent repair vulnerability after 50% bowel resection
Emilie E. Vomhof-DeKrey, Jack T. Lansing, Diane C. Darland, Josey Umthun, Allie D. Stover, Christopher Brown, Marc D. Basson
American Journal of Physiology-Gastrointestinal and Liver Physiology.2021; 320(2): G136. CrossRef
Phosphohistone H3 (PHH3) as a surrogate of mitotic figure count for grading in meningiomas: a comparison of PHH3 (S10) versus PHH3 (S28) antibodies
Napaporn Puripat, Kongsak Loharamtaweethong
Virchows Archiv.2019; 474(1): 87. CrossRef
Gastrointestinal Stromal Tumors Risk Stratification Utilizing Phospho-Histone H3 Evaluated by Manual Counting and Computer-Assisted Image Analysis
Cao Jin, Yan Huang, Mansoor Nasim, Yihe Yang, Lili Lee
International Journal of Surgical Pathology.2019; 27(7): 706. CrossRef
The utility of phosphohistone H3 in early prediction of benign and borderline phyllodes tumor recurrence
AymenM El-Saka, MohamedA Mlees, YomnaA Zamzam
Egyptian Journal of Pathology.2019; 39(2): 402. CrossRef
Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors
Min Jeong Kim, Mi Jung Kwon, Ho Suk Kang, Kyung Chan Choi, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Hyoung-Chul Park
BioMed Research International.2018; 2018: 1. CrossRef
Tumor Digital Masking Allows Precise Patient Triaging: A Study Based on Ki-67 Scoring in Gastrointestinal Stromal Tumors
Piotr Lewitowicz, Jaroslaw Matykiewicz, Magdalena Chrapek, Dorota Koziel, Agata Horecka-Lewitowicz, Martyna Gluszek-Osuch, Iwona Wawrzycka, Stanisław Gluszek
Scanning.2018; 2018: 1. CrossRef
The mitosis‐specific marker phosphohistone‐H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome‐based study
Kin‐Long Chow, Ka‐Yu Tse, Ching‐Lung Cheung, Ka‐Wing Wong, Annie N Y Cheung, Richard W C Wong, Alice N H Chan, Nancy W F Yuen, Hextan Y S Ngan, Philip P C Ip
Histopathology.2017; 70(5): 746. CrossRef

Brief Case Report

Supratentorial Hemangioblastoma with Unusual Features: Yooju Shin, Seokhwi Kim, Hyun-Woo Lee, Heejin Bang, Yeon-Lim Suh; Korean J Pathol. 2014;48(6):462-465. Published online December 31, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.6.462

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Citations

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Supratentorial Hemangioblastoma in Adults: A Systematic Review and Comparison of Infratentorial and Spinal Cord Locations
Dragan Jankovic, Kyna Vuong, Bruno Splavski, Kresimir Rotim, Kenan I. Arnautovic
World Neurosurgery.2023; 173: 48. CrossRef
Supratentorial hemangioblastoma: correlation between phenotype, gender and vascular territory affected
Yosef Laviv, David Saraf, Liat Oxman, Ido Ben Zvi
Neurosurgical Review.2023;[Epub] CrossRef
Neuropathologic features of central nervous system hemangioblastoma
Rebecca A. Yoda, Patrick J. Cimino
Journal of Pathology and Translational Medicine.2022; 56(3): 115. CrossRef
The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system
Tae Hoon Roh, Hyunee Yim, Jin Roh, Kyi Beom Lee, So Hyun Park, Seon-Yong Jeong, Se-Hyuk Kim, Jang-Hee Kim
Scientific Reports.2019;[Epub] CrossRef
Supratentorial hemangioblastomas in von Hippel–Lindau wild-type patients – case series and literature review
Luís Rocha, Carolina Noronha, Ricardo Taipa, Joaquim Reis, Mário Gomes, Ernesto Carvalho
International Journal of Neuroscience.2018; 128(3): 295. CrossRef
MR Imaging Findings of Supratentorial Meningeal Hemangioblastoma: A Case Report
Gi Hong Kim, Ho Kyu Lee, Myeong Ju Koh, Young Hee Maeng
Journal of the Korean Society of Radiology.2016; 75(1): 26. CrossRef

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