Journal of Pathology and Translational Medicine

Case Reports

Subcutaneous Fat Necrosis Associated with Pancreatic Adenocarcinoma: A case report.: Hee Jung Kim, Kwang Gil Lee; Korean J Pathol. 1996;30(2):155-160.

Abstract PDF: Subcutaneous fat necrosis is manifested by erythematous tender nodules on the legs, buttock or trunk and is associated with pancreatic disease including acute and chronic pancreatitis, pancreatic carcinoma, pseudocyst, pancreatic stone and other diseases. Its histologic findings are pathognomonic and reveal foci of subcutaneous fat necrosis with "ghost-like" anucleated cells with thick "shadowy wall" and surrounding inflammatory infiltrate consisting of polymorphonuclear cells, eosinophils, lymphocytes, histiocytes, foam cells and foreign body giant cells. We experienced a case of subcutaneous fat necrosis associated with pancreatic adenocarcinoma manifested by subcutaneous nodules in the buttock and lower extremities and by arthralgia of the left knee in a 67-year-old woman. Therefore, we are reporting to emphasize the importance of the skin findings of the internal disease.

Epithelioid Leiomyosarcoma of Skin: A case report.: Han Seong Kim, Nam Bok Cho, Hyun Soon Lee, Kye Yong Song; Korean J Pathol. 1998;32(9):700-703.

Abstract: This report concerns a rare malignant smooth muscle neoplasm of the skin and the subcutaneous tissue, which was examined immunohistochemically and ultrastructurally. It occured in a 48-year-old female patient who had suffered from painful nodules on the left shoulder. The nodules were removed and diagnosed as a benign fibrohistiocytic tumor. One year after local excision, multiple nodules were detected by physical examination at the previous operation site. Grossly, thirteen well-defined small nodules had spread in the dermis and the subcutaneous tissue, of which nine were located from lower dermis to the subcutaneous tissue and four were in the subcutaneous tissue. Histologically, each nodule consisted mainly of epithelioid tumor cells having eosinophilic or clear plump cytoplasm and round to oval nuclei with small nucleoli, and some peripheral spindle tumor cells. The tumor cells were negative for PAS reaction with and without diastase digestion or alcian blue. Immunohistochemically, tumor cells were positive for smooth muscle actin and vimentin. Ultrastructurally, the tumor cells showed actin filaments and dense bodies in cytoplasm. This case was diagnosed as an epithelioid leiomyosarcoma of the skin and the subcutaneous tissue with local metastasis one year after local excision.

Cutaneous Bronchogenic Cyst Over the Sternum: A Case Report.: Ho Sung Park, Hyun Jin Son, Myoung Jae Kang; Korean J Pathol. 2004;38(5):333-336.

Abstract PDF: Bronchogenic cyst is usually an extrapulmonary cyst formed as the result of an accessory lung bud from the foregut that becomes isolated from the rest of the tracheobronchial tree producing a usually solitary cyst. Most bronchogenic cysts are in the mediastinum with rare occurrence on the subcutaneous tissue over the sternum. We report a case of cutaneous bronchogenic cyst that occurred in the skin over the sternum in a 13-month-old boy. On ultrasonography, a well circumscribed non-echogenic cystic mass was observed measuring 1.5x1.3 cm. Histologically, the cyst was lined by cilicated, pseudostratified, columnar epithelium with interspersed goblet cells, and there were bundles of smooth muscle fibers, mucous glands, and lymphoid aggregates in the cyst wall.

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