Journal of Pathology and Translational Medicine

Original Article

The Effect of Splenectomy on Acute Barium Sulfate Induced Toxicity of Rat Organs.: Hae Joung Sul, Dae Young Kang; Korean J Pathol. 2004;38(4):249-257.

Abstract PDF: BACKGROUND
The purpose of this study was to elucidate whether or not splenectomy alters the acute toxic effects on rat tissue induced by barium sulfate.
METHODS
A total of 80 Sprague-Dawely male rats were divided into three groups; the control group and the barium sulfate treated groups with and without splenectomy. The pathologic changes in the solid organs were examined at the time after intraperitoneal treatment with barium sulfate. The changes of white blood cell count were also examined.
RESULTS
The barium induced toxicity was most prominent in the spleen. The changes in the other organs were proportional to the experimental duration, and the changes in the barium only treatment group were more severe than the observed changes in the splenectomy and barium treated group.
CONCLUSIONS
These results suggest that the degree of barium toxicity of barium only treated group was more severe than that of the splenectomy group.

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