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Original Articles
- Podocyte Expression of Osteopontin and FSP-1/S100A4 in Human Crescentic Glomerulonephritis.
- Ghil Suk Yoon, Tae Sook Kim
- Korean J Pathol. 2011;45(3):237-246.
- DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.3.237
- 3,413 View
- 33 Download
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Abstract
PDF - BACKGROUND
Osteopontin (OPN) is a cytokine associated with a cell-matrix via integrins. Fibroblast specific protein-1 (FSP-1), known as S100A4, has been implicated in cell migration by non-muscle myosin. We investigated whether the role of OPN and FSP-1/S100A4 expression in their contribution to the podocyte phenotype change to form podocyte bridge and cellular crescent.
METHODS
Glomerular expression of OPN and FSP-1/S100A4 in renal biopsies of 16 patients with crescentic glomerulonephritis (CrGN) and 13 normal renal biopsies were studied by immunohistochemistry.
RESULTS
The expression of OPN and FSP-1/S100A4 was increased in the podocytes of glomeruli, with and without crescents, in patients with CrGN. Neither OPN nor FSP-1/S100A4 was expressed in glomeruli from the normal controls (p<0.01). A significant positive correlation was found between the expression of OPN in glomerular tufts and cellular crescents, and the expression of OPN and FSP-1/S100A4 in glomerular tufts (p<0.05).
CONCLUSIONS
The results suggest that OPN plays a role in early podocyte attachment to Bowman's capsule, and FSP-1/S100A4 potentiate podocyte contribution to cellular crescent formation by inducing cellular migration and growth.
- Clinicopathological Significance of S100A4 Expression in Non-small Cell Lung Carcinomas.
- Eun Ah Jung, Hyun Deuk Cho, Ji Hye Lee, Mee Hye Oh
- Korean J Pathol. 2010;44(5):477-482.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.477
- 3,869 View
- 27 Download
- 6 Crossref
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Abstract
PDF
- BACKGROUND
S100A4 has been implicated in invasion and metastasis of various malignant tumors. The aim of this study was to investigate whether or not S100A4 plays an important role in non-small cell lung carcinomas (NSCLCs).
METHODS
Sixty-seven patients with NSCLC including 37 with squamous cell carcinomas (SCCs) and 30 with adenocarcinomas (ADs) who had undergone surgical resection were analyzed. S100A4 expression was analyzed by immunohistochemistry using tissue microarray blocks.
RESULTS
S100A4 expression was positive in 56 (83.6%) of 67 NSCLC cases. ADs were more frequently S100A4 positive than SCCs (p = 0.017). However, no significant correlation was observed between S100A4 expression and age, gender, pT, pN or tumor, node and metastasis (TNM) stage. Two distant metastatic cases revealed an S100A4 positive reaction. Kaplan-Meier survival curves with the log-rank test showed no correlation with 3-year survival (p = 0.782) or 5-year survival (p = 0.227) in either group of patients according to S100A4 expression.
CONCLUSIONS
S100A4 expression was not correlated with age, gender, pT, pN or TNM stage or survival in patients with NSCLCs. Therefore, S100A4 expression may not be useful as a prognostic marker for NSCLCs. However, S100A4 expression showed a higher positivity in ADs than in SCCs. -
Citations
Citations to this article as recorded by
- Clinicopathological and prognostic value of S100A4 expression in non-small cell lung cancer: a meta-analysis
Jing Zhang, Yanhui Gu, Xiaoli Liu, Ximin Rao, Guichuan Huang, Yao Ouyang
Bioscience Reports.2020;[Epub] CrossRef - S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation
TENG HUA, SHUANGGE LIU, XIAOYAN XIN, LIQIONG CAI, RUI SHI, SHUQI CHI, DILU FENG, HONGBO WANG
Oncology Reports.2016; 35(6): 3419. CrossRef - Prognostic value of cytoplasmic expression of S100A4 protein in endometrial carcinoma
HYE IN CHONG, JEONG HEE LEE, MAN SOO YOON, DONG SOO SUH, KYUNGBIN KIM, JEE YEON KIM, KYUNG UN CHOI
Oncology Reports.2014; 31(6): 2701. CrossRef - Clinical significance of E-cadherin, β-catenin, vimentin and S100A4 expression in completely resected squamous cell lung carcinoma
Hua Zhang, Jun Liu, Dongsheng Yue, Liuwei Gao, Daowei Wang, Hongdian Zhang, Changli Wang
Journal of Clinical Pathology.2013; 66(11): 937. CrossRef - Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer
Ane Kongsgaard, Marius Lund-Iversen, Gisle Berge, Odd Terje Brustugun, Steinar K Solberg, Gunhild M Mælandsmo, Kjetil Boye
BMC Cancer.2012;[Epub] CrossRef - Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer
Ho Won Lee, Eui Han Kim, Mee-Hye Oh
Korean Journal of Pathology.2012; 46(5): 470. CrossRef
- Clinicopathological and prognostic value of S100A4 expression in non-small cell lung cancer: a meta-analysis
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