Journal of Pathology and Translational Medicine

Case Study

Rosette-forming epithelioid osteosarcoma in the rib: a rare case of location and morphology: Sun-Ju Oh; J Pathol Transl Med. 2021;55(6):406-409. Published online August 3, 2021; DOI: https://doi.org/10.4132/jptm.2021.06.22

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The rib is an unusual location for osteosarcoma and is reported in only 2% of all cases. The major histological variants of osteosarcoma are osteoblastic, chondroblastic, and fibroblastic, with a few rare variants including one epithelioid type. This report describes a 44-year-old male with an osteolytic mass in the right seventh rib. Histological examination revealed osteosarcoma with unique features of epithelioid appearance and rosette structures. To the best of our knowledge, this is the first reported case of a rosette-forming osteosarcoma of the rib that showed epithelioid morphology. Despite successful surgery, the patient’s prognosis was poor because this malignancy had an unusual location within the axial skeleton and was a rare histological variant.

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Clinicopathological correlations and prognostic insights in osteosarcoma: a retrospective analysis
Ştefan Adrian Niculescu, Alexandru Florian Grecu , Alex Emilian Stepan , Mădălina Iuliana Muşat , Aritina-Elvira Moroşanu , Tudor Adrian Bălşeanu , Michael Hadjiargyrou , Dan Cristian Grecu
Romanian Journal of Morphology and Embryology.2025; 65(4): 723. CrossRef

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