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Review Article
- Multiple sclerosis: a practical review for pathologists
- Rachel A. Multz, Pouya Jamshidi, Jared T. Ahrendsen
- J Pathol Transl Med. 2025;59(4):203-213. Published online June 27, 2025
- DOI: https://doi.org/10.4132/jptm.2025.05.20
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- 2 Web of Science
- 3 Crossref
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Abstract
PDF - Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system. It is a chronic disorder resulting in neurologic dysfunction that is disseminated both in time (multiple discrete episodes) and space (involving multiple sites). Histologically, MS is characterized by localized loss of myelin with relative preservation of axons. This review will discuss the epidemiology, clinical, laboratory, radiologic, and pathologic features of multiple sclerosis, as well as briefly touch on the differential diagnosis, treatment, and prognosis of the disease, especially as they relate to the pathologic interpretation of tissue specimens.
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Citations
Citations to this article as recorded by
- White Matter in Crisis: Oligodendrocytes and the Pathophysiology of Multiple Sclerosis
Mario García-Domínguez
Cells.2025; 14(18): 1408. CrossRef - Tumefactive demyelinating lesions: a case report and literature review
Raneem Jaki, Zyad Al-Frejat, Ziad Bitar
BMC Neurology.2025;[Epub] CrossRef - Liquerologia: Uma ferramenta no diagnóstico de esclerose múltipla e outras doenças neurodegenerativas e desmielinizantes
Laura Maria de Araújo Pereira, Talyta Valeria Siqueira do Monte Guedes, Rafaell Batista Pereira, Davi Abrantes Lucena Messias, Marfran José Cunha Urtiga, Davi Rodrigues Vieira, Samuel da Costa Chaves Trindade Martins, José Guedes da Silva Júnior
Research, Society and Development.2025; 14(12): e72141249815. CrossRef
- White Matter in Crisis: Oligodendrocytes and the Pathophysiology of Multiple Sclerosis
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