Journal of Pathology and Translational Medicine

Original Article

Special AT-rich sequence-binding protein 2 (SATB2) in the differential diagnosis of osteogenic and non-osteogenic bone and soft tissue tumors: Sharon Milton, Anne Jennifer Prabhu, V. T. K. Titus, Rikki John, Selvamani Backianathan, Vrisha Madhuri; J Pathol Transl Med. 2022;56(5):270-280. Published online September 13, 2022; DOI: https://doi.org/10.4132/jptm.2022.07.11

7,295 View
135 Download
7 Web of Science
9 Crossref

Background
The diagnosis of osteosarcoma (OSA) depends on clinicopathological and radiological correlation. A biopsy is considered the gold standard for OSA diagnosis. However, since OSA is a great histological mimicker, diagnostic challenges exist. Immunohistochemistry (IHC) can serve as an adjunct for the histological diagnosis of OSA. Special AT-rich sequence-binding protein 2 (SATB2) was recently described as a reliable adjunct immunohistochemical marker for the diagnosis of OSA.
Methods
We investigated the IHC expression of SATB2 in 95 OSA and 100 non-osteogenic bone and soft tissue tumors using a monoclonal antibody (clone EPNCIR30A). The diagnostic utility of SATB2 and correlation with clinicopathological parameters were analyzed.
Results
SATB2 IHC was positive in 88 out of 95 cases (92.6%) of OSA and 50 out of 100 cases (50.0%) of primary non-osteogenic bone and soft tissue tumors. Of the 59 bone tumors, 37 cases (62.7%) were positive for SATB2, and of the 41 soft tissue tumors, 13 cases (31.7%) were positive for SATB2. The sensitivity of SATB2 as a diagnostic test was 92.6%, specificity 50%, positive predictive value 63.8%, and negative predictive value 87.7%.
Conclusions
Although SATB2 is a useful diagnostic marker for OSA, other clinical, histological and immunohistochemical features should be considered for the interpretation of SATB2.

Citations

Citations to this article as recorded by

The diagnostic utility of SATB2 immunohistochemistry as an adjunct for differentiating osteogenic from non-osteogenic bone tumors: A systematic review and Meta-analysis
Yuchen Lou, Xuan Liu, Chenxiao Ma, Xin Liu
Bone.2026; 203: 117721. CrossRef
Immunohistochemical Characterization of Feline Giant Cell Tumor of Bone (GCTb): What We Know and What We Can Learn from the Human Counterpart
Ilaria Porcellato, Giuseppe Giglia, Leonardo Leonardi
Animals.2025; 15(5): 699. CrossRef
Epigallocatechin gallate impels osteogenic differentiation of human BMSCs by targeting the METTL3/SATB2/Wnt/β-catenin axis
Qiao Ren, Kang Chen, Lin Wang
Letters in Drug Design & Discovery.2025; 22(3): 100027. CrossRef
A case of cardiac undifferentiated pleomorphic sarcoma treated with post-operative radiotherapy followed by heart transplantation
Sungyeon Jung, Eun Na Kim, Hye In Lee, Hak Jae Kim, Jiwon Koh
Cardiovascular Pathology.2025; 79: 107760. CrossRef
Osteoblastic Osteosarcoma With Diverse Histomorphology: Diagnostic Insights From SATB2 and CD56 Immunoexpression
Padmaraj Hegde, Reshma Amin, Vijith Vittal Shetty, Pushparaja Shetty
Journal of Health and Allied Sciences NU.2025; 0: 1. CrossRef
High-throughput 3D engineered paediatric tumour models for precision medicine
MoonSun Jung, Valentina Poltavets, Joanna N Skhinas, Gabor Tax, Alvin Kamili, Jinhan Xie, Sarah Ghamrawi, Philipp Graber, Jie Mao, Marie Wong-Erasmus, Louise Cui, Kathleen Kimpton, Pooja Venkat, Chelsea Mayoh, Angela Lin, Emmy D G Fleuren, Ashleigh M Ford
Molecular Systems Biology.2025; 21(12): 1748. CrossRef
SATB2 immunohistochemistry in osteosarcoma: Utility in diagnosis and differentiation from histologic mimics
Supriya Gangula, Monalisa Hui, Shantveer G. Uppin, B Arvind Kumar, K Nageshwara Rao, B Rajeev Reddy, G Sadashivudu
Indian Journal of Pathology and Microbiology.2025; 68(3): 518. CrossRef
Early-onset metastatic fibroblastic osteosarcoma of the metatarsus in a young cat: a case report
Mojtaba Kiakojoori, Hossein Kazemi Mehrjerdi, Ali Mirshahi, Mahdieh Zaeemi, Mohsen Maleki
BMC Veterinary Research.2025;[Epub] CrossRef
Favorable treatment response to high‐grade sarcoma in neurofibromatosis 1
Michelle H. Talukder, Mauli M. Patel, Tala Al‐Saghir, Ghadir K. Katato, Janet Poulik, William J. Powell, Alysia K. Kemp, Steven Miller, Danielle Bell, Jeffrey W. Taub
Pediatric Blood & Cancer.2023;[Epub] CrossRef

Case Studies

Rosette-forming epithelioid osteosarcoma in the rib: a rare case of location and morphology: Sun-Ju Oh; J Pathol Transl Med. 2021;55(6):406-409. Published online August 3, 2021; DOI: https://doi.org/10.4132/jptm.2021.06.22

5,585 View
139 Download
2 Web of Science
2 Crossref

Abstract PDF

The rib is an unusual location for osteosarcoma and is reported in only 2% of all cases. The major histological variants of osteosarcoma are osteoblastic, chondroblastic, and fibroblastic, with a few rare variants including one epithelioid type. This report describes a 44-year-old male with an osteolytic mass in the right seventh rib. Histological examination revealed osteosarcoma with unique features of epithelioid appearance and rosette structures. To the best of our knowledge, this is the first reported case of a rosette-forming osteosarcoma of the rib that showed epithelioid morphology. Despite successful surgery, the patient’s prognosis was poor because this malignancy had an unusual location within the axial skeleton and was a rare histological variant.

Citations

Citations to this article as recorded by

Clinicopathological correlations and prognostic insights in osteosarcoma: a retrospective analysis
Ştefan Adrian Niculescu, Alexandru Florian Grecu , Alex Emilian Stepan , Mădălina Iuliana Muşat , Aritina-Elvira Moroşanu , Tudor Adrian Bălşeanu , Michael Hadjiargyrou , Dan Cristian Grecu
Romanian Journal of Morphology and Embryology.2025; 65(4): 723. CrossRef
Cytohistologic Diagnosis of Rosette‐Forming Epithelioid Osteosarcoma
Brant G. Wang
Diagnostic Cytopathology.2025;[Epub] CrossRef

Multifocal Osteosarcoma of the Skull: Multiple Primary or Metastatic? A Case Report: Hyuck Cho, Bong-jin Park, Yong-Koo Park; Korean J Pathol. 2014;48(2):146-150. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.146

11,848 View
57 Download
7 Crossref

Abstract PDF

Osteosarcoma of the skull is a very rare condition. Moreover, it is extremely rare for osteosarcoma to present as multiple lesions confined to the skull. A 58-year-old woman was admitted with two masses in the parietal area of the skull, accompanied by mild headache and tenderness. Imaging revealed two masses with a heterogeneous consistency in the cranial bones. Excision craniectomy was performed and the pathology was consistent with osteoblastic osteosarcoma. Two nodules in the heart were found on routine follow-up imaging while the patient was undergoing chemotherapy. The nodules were biopsied and found to be metastatic osteosarcoma.

Citations

Citations to this article as recorded by

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma
Shihao Li, Lina Zhang, Haiyang Zhang
Frontiers in Pharmacology.2025;[Epub] CrossRef
Osteosarcoma multicéntrico sincrónico. Un caso en niño de 10 años y revisión de la literatura
Jesús Pérez-García, Osvaldo Velasco-Donado, Karoll Robles-Pérez
Revista Española de Patología.2022; 55: S11. CrossRef
Reconstruction using a frozen autograft for a skull and humeral lesion of synchronous multicentric osteosarcoma after undergoing successful neoadjuvant chemotherapy: a case report and review of the literature
Yoshihiro Araki, Katsuhiro Hayashi, Norio Yamamoto, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano, Takayuki Nojima, Hiroyuki Tsuchiya
BMC Surgery.2021;[Epub] CrossRef
What’s that big thing on your head? Diagnosis of a large frontoparietal lesion on an Eastern Zhou skull from Henan, China
Kate Pechenkina, Wenquan Fan, Xiaodong Luo
International Journal of Paleopathology.2019; 26: 84. CrossRef
Kalvaryumda multifokal osteosarkom: Nadir bir vaka sunumu ve literatür derlemesi
Neslihan KURTUL, Nursel YURTTUTAN, A. Yasir BAHAR, Gökmen AKTAŞ
Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi.2019; 14(3): 151. CrossRef
Radiological review of skull lesions
Carrie K. Gomez, Scott R. Schiffman, Alok A. Bhatt
Insights into Imaging.2018; 9(5): 857. CrossRef
Multifocal Osteosarcoma
Somali Gavane, Anita P. Price, Heather Magnan, Sonia Mahajan, Neeta Pandit-Taskar
Clinical Nuclear Medicine.2017; 42(4): e202. CrossRef

Original Article

14-bp Insertion/Deletion Polymorphism of the HLA-G Gene in Osteosarcoma Patients.: Ahrim Moon, Su Kang Kim, Joo Ho Chung, Ki Yong Na, Liliana G Olvi, Eduardo Santini-Araujo, Youn Wha Kim, Yong Koo Park; Korean J Pathol. 2011;45(5):485-490.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.5.485

4,768 View
20 Download
1 Crossref

Abstract PDF

BACKGROUND
The major histocompatibility complex class I, G (human leukocyte antigen-G [HLA-G]) gene plays a vital role in the suppression of immune responses. Recently, a number of studies have reported an association between HLA-G and diseases (pregnancy complications, organ transplantation, and tumors). Some of the studies have revealed that the 14-bp insertion/deletion polymorphism might be associated with various diseases. The aim of the present study was to explore a possible influence of the 14-bp insertion/deletion polymorphism on osteosarcoma.
METHODS
Genomic DNA was extracted from 75 formalin-fixed, paraffin-embedded tumor tissues derived from patients with conventional osteosarcoma (OSA) and 183 peripheral blood samples of healthy controls. Fifty-eight cases were South Korean patients with OSA and 17 cases were Argentine patients with OSA. The HLA-G 14-bp insertion/deletion polymorphism at exon 8 of the HLA-G locus was analyzed by polymerase chain reaction.
RESULTS
There was a significantly different distribution profile for the 14-bp genotypes between the Korean OSA and Korean control groups. Specifically, there were more heterozygote 210 bp/224 bp genotypes in the Korean OSA group when compared to the Korean control group (62.1% vs 40.4%, p=0.002).
CONCLUSIONS
The results suggest that HLA-G heterozygote patients may be more susceptible to OSA in the Korean population.

Citations

Citations to this article as recorded by

14-bp Insertion/Deletion Polymorphism of the HLA-G gene in Breast Cancer among Women from North Western Iran
Mehdi Haghi, Mohammad Ali Hosseinpour Feizi, Majid Sadeghizadeh, Abbas Sahebghadam Lotfi
Asian Pacific Journal of Cancer Prevention.2015; 16(14): 6155. CrossRef

Case Report

Parotid Gland Carcinosarcoma with Osteosarcoma as a Sarcomatous Component: A Case Report with Fine Needle Aspiration Cytologic Findings.: Se Min Jang, Young Jin Jun, Hulin Han, Ki Seok Jang, Seung Sam Paik; Korean J Pathol. 2011;45(4):412-416.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.412

4,508 View
43 Download
2 Crossref

Abstract PDF

Carcinosarcoma of the salivary glands is a rare malignant tumor showing both malignant epithelial and mesenchymal components. Herein, we present a carcinosarcoma of the parotid gland in a 67-year-old man consisting of osteosarcoma and adenocarcinoma components with fine needle aspiration cytological findings. The tumor was composed predominantly of osteosarcoma and small areas of adenocarcinomatous components and a hyalinized nodule reminiscent of pleomorphic adenoma. The tumor showed infiltrative growth features with perineural, lymphatic, and vascular invasion. Despite postoperative adjuvant radiation therapy, multiple metastatic lesions occurred in the both lungs 5 months after surgery. As salivary gland carcinosarcoma has been known to demonstrate highly aggressive behavior, an accurate pathological diagnosis is prerequisite for appropriate treatment.

Citations

Citations to this article as recorded by

Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review
Alexandra Corina Faur, Alina Maria Șișu, Laura Andreea Ghenciu, Roxana Iacob, Emil Robert Stoicescu, Ovidiu Alin Hațegan, Mărioara Cornianu
Diagnostics.2024; 14(17): 1942. CrossRef
Carcinosarcoma of the parotid gland with abdominal metastasis: a case report and review of literature
Chang Gok Woo, Seung-Myoung Son
World Journal of Surgical Oncology.2018;[Epub] CrossRef

Original Articles

The Global Histone Modification Patterns of Osteosarcoma.: Sung Im Do, Sung Jig Lim, Youn Wha Kim, Liliana G Olvi, Eduardo Santini-Araujo, Yong Koo Park; Korean J Pathol. 2011;45(2):146-150.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.2.146

3,221 View
18 Download

Abstract PDF: BACKGROUND
Epigenetic alteration may affect a patient's prognosis by altering the development and progression of the tumor. Some recent reports have identified a correlation between histone modification and patient outcome. However, no studies have been conducted on global histone modification in osteosarcomas.
METHODS
We investigated histone modification in 54 cases of osteosarcoma by performing immunohistochemical staining. The immunohistochemical expression of four histone modification markers, acetylated H4 lysine 12 (H4K12Ac), acetylated H3 lysine 18, trimethylated H3 lysine 27, and dimethylated H3 lysine 4 were evaluated.
RESULTS
High H4K12Ac expression was correlated with patient age (p=0.011). However, the other histone modification markers showed no correlation with any of the clinicopathological data such as survival, tumor grade, tumor site, metastasis, age, or gender.
CONCLUSIONS
Our study showed that all four histone modification markers are expressed in osteosarcoma (median expression rate, 40 to 60%). However, we did not find a correlation with the clinicopathological factors except for age. Further study to evaluate the reason for the association between H4K12Ac and patient age is needed.

Expression of Carbonic Anhydrase IX Correlates with Histologic Grade and Metastasis in Osteosarcoma.: Hye Rim Park, Jinwon Seo, Patrizia Bacchini, Franco Bertoni, Yong Koo Park; Korean J Pathol. 2010;44(4):384-389.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.384

3,580 View
21 Download
1 Crossref

Abstract PDF

BACKGROUND
Carbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in osteosarcoma. We aimed to assess the prevalence of CA9 expression and its prognostic implications in osteosarcoma patients.
METHODS
We compared immunohistochemical expression of CA9 between conventional, high-grade and low-grade, central osteosarcomas. Specimens were obtained before chemotherapy and stained with anti-human CA9 antibody. We also evaluated the histologic grade, presence of metastasis, and patient prognosis.
RESULTS
Among 38 samples of conventional high-grade osteosarcoma, 22 (57.9%) tumors displayed CA9 overexpression. Twenty-five cases of low-grade central osteosarcomas were all negative (p < 0.0001). CA9 expression was significantly associated with the presence of metastasis (p = 0.0010). The overall survival rate was significantly reduced with increased CA9 expression (p = 0.0012), higher histologic grade (p < 0.0001), and younger age (p = 0.0140). However, the overall survival rate was not significantly correlated with gender, tumor size, or American Joint Committee on Cancer stage.
CONCLUSIONS
CA9 expression is a frequent and tumor-specific event in osteosarcoma. CA9 expression is associated with higher grade tumors, metastasis and poor prognosis for the osteosarcoma patients.

Citations

Citations to this article as recorded by

The reducing effect of TNF-α on carbonic anhydrase III gene expression in colon carcinoma and osteosarcoma cells
Sümeyye Aydoğan Türkoğlu, Derya Okuyan, Feray Köçkar
Cytotechnology.2025;[Epub] CrossRef

Lyn Expression in Osteoblastic Osteosarcoma Tissues and Its Correlation with Clinicopathologic Factors.: Min Sun Jin, Shin Kwang Khang, Min Suk Kim, Hee Seung Choi, Jung Eun Lee, Kil Ho Kim, Dae Geun Jeon, Jae Soo Koh; Korean J Pathol. 2010;44(2):125-131.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.2.125

4,065 View
19 Download
2 Crossref

Abstract PDF

BACKGROUND
The Src family kinases (SFKs) are involved in multiple aspects of tumorigenesis, such as, proliferation, migration, and angiogenesis, and are involved in the generation and progression of many types of tumors. Furthermore, dasatinib, a general SFKs inhibitor was recently approved for use in chronic myeloid leukemia. This study was performed to evaluate the expression of Lyn, a member of the SFKs, in osteosarcoma tissues.
METHODS
One hundred and sixteen patients with osteoblastic osteosarcoma were selected for Lyn expression analysis. The correlation between Lyn expression in tumor sections and patients' clinicopathologic characteristics and the prognostic significance of Lyn expression were evaluated.
RESULTS
Lyn was found to be expressed in 52 of the 116 patients (44.8%), and Lyn positive tumor was found to be significantly associated with a lytic tumor pattern on plain radiographs (p = 0.04). Furthermore, those positive for Lyn showed longer metastasis free survival (5-year metastasis free survival, 65.2% for Lyn positive and 46.8% for Lyn negative; p = 0.06), though this was only marginally significant.
CONCLUSIONS
Lyn was found to be overexpressed in osteosarcoma tissues, and this overexpression was found to be correlated with osteolysis.

Citations

Citations to this article as recorded by

Eight Aging-Related Genes Prognostic Signature for Cervical Cancer
Meilin Yin, Yanhua Weng, Ferenc Olasz
International Journal of Genomics.2023; 2023: 1. CrossRef
LYN expression predicts the response to dasatinib in a subpopulation of lung adenocarcinoma patients
Yu Jin Kim, Sungyoul Hong, Minjung Sung, Min Jeong Park, Kyungsoo Jung, Ka-Won Noh, Doo-Yi Oh, Mi-Sook Lee, Ensel Oh, Young Kee Shin, Yoon-La Choi
Oncotarget.2016; 7(50): 82876. CrossRef

Case Reports

Metastatic Osteosarcoma to the Prostate: A Case Report.: Hyoung Yeon Seo, Jae Hyuk Lee, Chang Soo Park, Jin Gyoon Park, Sung Taek Jung; Korean J Pathol. 2009;43(5):475-477.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.5.475

4,647 View
29 Download

Abstract PDF: The most common site for the metastasis of osteosarcoma is the lung, and other sites of metastases include the bone, lymph node, pleura and liver. Although unusual extrapulmonary metastases have been reported with the improvement of the therapeutic results for the primary lesions, they are exceptionally rare. We report here on a case of prostatic metastasis of an osteosarcoma of the proximal tibia, and this developed seven years after successful resection, and four years after resection of a pulmonary metastasis. Radical prostatectomy was performed, and histological examination demonstrated metastatic osteosarcoma. To the best of our knowledge, this is the first case of prostatic metastasis of osteosarcoma in the medical literature.

Intraosseous Well Differentiated Osteosarcoma: A case report.: Mee Hye Oh, So Young Park, Yeon Lim Suh, Shin Khang Kang; Korean J Pathol. 1992;26(6):627-631.

2,055 View
16 Download

Abstract PDF: Well differentiated osteosarcomas are variants of osteosarcoma composed mainly of fibrous and osseous tissue with minimal cystologic atypia. This tumor may be misinterpretated as a benign lesion if the radiologic and clinical features are not taken into account. We report a typical case of intraosseous well differentiated osteosarcoma occuring in the left distal femur of a 58-year-old woman. Radiologically, it appered as an ill-defined lesion with a mixture of sclerotic and osteolytic ares. But there was a lack of highly destructive appearance of conventional osteosarcoma. Grossly, the mass occupied a metaphysis of the distal femur with extension into the diaphysis and epiphysis. Multifocal cortical destruction and sclerosis were also associated. Histologically, the mass showed typical features of intraosseous well differentiated osteosarcoma. There were various patterns of osteoid deposits and bone formation mimicking those of fibrous dysplasia, nonossifying fibroma or parosteal osteosarcoma.

Collision Tumor Composed of Papillary Transitional Cell Carcinoma, and Osteosarcoma in Urinary Bladder: A cases report.: Nam Hoon Cho, Chanil Park; Korean J Pathol. 1995;29(3):374-377.

1,973 View
16 Download

Abstract PDF: This is to report a case of collision tumor of the urinary bladder, which was composed of papillary transitional cell carcinoma(PTCC) and osteosarcoma. Grossly the tumor was located at left antero-lateral wall and was a fungating, gray yellow, bony hard mass with papillary configuration of the luminal surface. Histologically the tumor was composed of PTCC confined to the mucosa and sarcomatous component not intermixed with the overlying PTCC. The sarcomatous area had features of classic osteosarcoma with anaplastic tumor cells and haphazardly arranged osteoid matrix, and was positive for osteonectin but entirely negative for cytokeratin or epithelial membrane antigen. Ultrastructural study demonstrated the tumor cells to be osteoblast which had rich rERs and a few lipid vesicles in plump cytoplasm without any evidence of epithelial ongin. The case is thought to be an example of collision tumor because there was no evidence of transition between PTCC and osteosarcoma.

Small Cell Osteosarcoma Similar to Ewing's Sarcoma in Histologic Findings and MIC2 Expression: A case report.: Yoon Mee Kim, Suk Woo Yang, Mee Yon Cho, Soon Won Hong, Byung Ho Choi; Korean J Pathol. 1999;33(3):204-209.

2,511 View
38 Download

Abstract PDF: Small cell osteosarcoma is a rare form of osteosarcoma and the histological differential diagnosis from other small round cell tumors (SRCTs) is difficult. The immunohistochemical stain for MIC2 has been considered an useful diagnostic marker for Ewing's sarcoma and primitive neuroectodermal tumors but recently, other SRCTs such as malignant lymphoma and embryonal rhabdomyosarcoma also showed positive reaction. Therefore, the usefulness of MIC2 must still be proven. We experienced a case of small cell osteosarcoma of the mandible in a 25-year-old man. Histologically, the tumor consisted of small round cells that resembled those of Ewing's sarcoma. Immunohistochemically, the tumor cells expressed diffuse strong positive reaction for MIC2 gene products. However, the scanty foci of lacy osteoid material between the tumor cells seemed to be diagnostic of osteosarcoma. The histologic and immunohistochemical findings of this case suggest close relationship between small cell osteosarcoma and Ewing's sarcoma.

Spontaneous Pneumothorax as a Complication of Pulmonary Metastasis of Osteosarcoma A case report.: Min Kyung Kim, Bong Kyung Shin, Wha Eun Oh, Ae Ree Kim, Nam Hee Won, Jong Sang Choi; Korean J Pathol. 1999;33(4):281-284.

2,558 View
41 Download

Abstract PDF: Spontaneous pneumothorax is a known, but relatively rare complication of pulmonary metastases of sarcoma. A 19-year-old man was presented with chest pain and dyspnea for three days and was diagnosed as left pneumothorax. After bleb resection, microscopic examination revealed metastatic osteosarcoma forming subpleural fistula and dystrophic calcification. Four years ago, he had had limb salvage operation and chemotherapy for osteosarcoma of left femur. After two and a half years he had a bleb resection for right pneumothorax without any evidence of metastasis. Six months later, he was found to have a 4x3cm sized lung mass in the right lower lobe. After lobectomy, he was diagnosed as pulmonary metastasis of osteosarcoma. Pneumothorax is the common complication of metastatic osteosarcoma to the lung and it may be presented before the pulmonary metastasis is clinically evident. It is important to recognize a pneumothorax of the patients with osteosarcoma as a possible sign of metastases.

Original Article

Imprint Cytologic Feature of Extraskeletal Osteosarcoma: A Case Report.: Mi Jin Gu, Young Kyung Bae, Mi Jin Kim, Joon Hyuk Choi, Won Hee Choi; J Pathol Transl Med. 2000;11(1):59-63.

2,090 View
18 Download

Abstract PDF: Extraskeletal osteosarcoma is an uncommon tumor originated from soft tissue without evidence of skeletal involvement. It usually affects adults and its common locations are extremity, buttock, and retroperitoneum. Although the histologic feature of this tumor is well known, there have been few reports on the fine needle aspiration cytologic findings. We report the imprint cytologic feature of extraskeletal osteosarcoma. The patient was a 49-year-old man with a mass of the left anterior chest for 2 years. On the imprint preparation, the smears showed malignant round, polygonal or spindle cells with coarsely clumped chromatin and occasionally prominent nucleoli. The malignant cells occur singly, in clusters, or associated with amorphous eosinophilic osteoid. Mitotic figures are also seen.

Case Reports

Extraskeletal Osteosarcoma of the Sole: A case report.: Ki Ouk Min, Mi Kyung Jee, Seok Jin Kang, Byoung Kee Kim, Sun Moo Kim; Korean J Pathol. 1993;27(3):279-282.

1,860 View
12 Download

Abstract PDF: Compared with osteosarcoma of bone, primary osteosarcoma of the soft tissue is very rare. Extraskeletal osteosarcoma is also a highly malignant pleomorphic sarcoma composed of cells exhibiting primarily osteoblastic, and to a lesser extent, chondroblastic differentiation. A case of extraskeletal osteosarcoma in the right sole is presented in a 67 year old male. The patient had noticed a progressively enlarging soft tissue mass, during about 14 months. This sarcoma was located in the soft tissues without attachment to the skeleton, as determined by examination of the X-Ray findings. The mass of right plantar portion was simply excised and pathologically confirmed to be an extraskeletal osteosarcoma. The clinical and pathological features of this sarcoma are described, and brief review of the literature is made.

Extraskeletal Osteosarcoma of the Posterior Mediastinum: A Case Report.: Weon Cheol Han, Hyang Jung Cho, Jai Kyoo Lee, Hyung Bae Moon, Jae Y Ro; Korean J Pathol. 2004;38(5):350-352.

2,093 View
19 Download

Abstract PDF: Extraskeletal osteosarcoma is a rare malignant tumor of soft tissue. In addition, there are only several cases of osteosarcoma of the mediastinum as a primary site in the world. We report a case of extraskeletal osteosarcoma arising in the posterior mediastinum. A 54-year-old man visited our hospital because of chest pain. Chest CT showed a 12 cm sized huge mediastinal mass. The mass revealed solid and ivory-colored cut surface with multifocally ovoid cystic spaces and hemorrhage. Microscopically, the tumor consisted of polygonal stromal cells, giant cells and varying amounts of neoplastic new bone, and mitotic figures were frequently observed. There were no distant metastasis and regional lymph node involvement.

A Well-Differentiated Extraskeletal Osteosarcoma: A Case Report.: Jung Wook Yang, Dae Hyun Song, Dong Hee Kim, Gyung Hyuck Ko; Korean J Pathol. 2008;42(4):247-250.

2,024 View
16 Download

Abstract PDF: A well-differentiated extraskeletal osteosarcoma is very rare, and only seven cases have been reported in the English language clinical literature. We report an additional case of this rare tumor. A 71-year-old man had noticed a mass in the left pubic area for ten years. A CT scan demonstrated the presence of a lobulated calcified mass within the soft tissue. A 5 cm-sized well-circumscribed mass was excised. Histologically the tumor was composed of mature collagenous tissue and bony trabeculae rimmed by osteoblasts. After 43 months, the tumor recurred at the same site and was re-excised. The re-excised tumor contained focal areas of higher cellularity and atypism. We believe that this is the first case of well-differentiated extraskeletal osteosarcoma reported in Korea.

Intestinal Metastasis of Osteosarcoma Presenting with Intussusception: A Case Report.: Seong Ho Yoo, Min A Kim, Kyu Joo Park, Joon Koo Han, Sang Hoon Lee, Chong Jai Kim, Eui Keun Ham; Korean J Pathol. 2002;36(4):271-273.

2,368 View
17 Download

Abstract PDF: Metastatic osteosarcoma most commonly affects the lungs and other bones. Intestinal intussusception caused by metastatic osteosarcoma is very rare. We report a case of metastatic osteosarcoma of the intestine in a 39-year-old female. She underwent surgical resection of the left femur due to osteosarcoma and received additional chemotherapy 3 years ago. Pulmonary metastasis was found two years later and the patient complained of abdominal pain, nausea and vomiting after 8 months following excision of the lung nodules. Abdominal computed tomography revealed intussusception with a suspected polypoid mass in the distal portion of the jejunum. The histologic findings of the resected bowel were those of osteosarcoma. This is the first case of documented intestinal metastasis of osteosarcoma in Korea. It is suggested that the tumor metastasis to the small intestine should be considered in patients with previous osteosarcoma, when the patient presents with acute abdominal symptoms and intussusception.

Original Article

The Expression of Matrix Metalloproteinase-9 and Tumor Angiogenesis in Human Osteosarcoma.: Jinyoung Yoo, Ji Han Jung, Hyun Joo Choi, Seok Jin Kang, Anhi Lee, Eun Joo Seo, Sang In Shim, Chang Suk Kang; Korean J Pathol. 2005;39(6):418-423.

2,203 View
18 Download

Abstract PDF: BACKGROUND
Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme that's believed to play a crucial role not only for tumor invasion and metastasis, but also for a variety of stromal reactions, including neovascularization. The aim of this study was to investigate the expression of MMP-9 and to compare its expression with the angiogenesis activity in human osteosarcoma.
METHODS
Archival tumor tissue samples from 20 patients with osteosarcoma were analyzed by performing immunohistochemistry for the expression of MMP-9 and CD34. The vascularity was measured as the average microvascular density (MVD) of the CD34-positive vessels. The clinical information was obtained through searching the computerized retrospective database from the tumor registry.
RESULTS
MMP-9 was expressed in 90% (18/20) of the tumors we examined. The MVD ranged from 10.5 to 179.7 with a mean of 64.9. There was no significant correlation between the MMP-9 expression and the MVD (p=.613). The MMP-9 expression was not associated with any of the clinicopathologic variables, whereas the MVD showed an increasing tendency according to the metastasis status (p=.073).
CONCLUSIONS
We demonstrated that MMP-9 activation is likely to occur in human osteosarcoma. However, there was no direct involvement of MMP-9 with tumor angiogenesis. It is noteworthy that MVD may aid physicians to predict the presence of distant metastasis in osteosarcoma patients.

Case Report

Osteosarcoma of the Skull Resembling Desmoplastic Fibroma: A Case Report.: Ingu Do, Eui Jong Kim, Gook Ki Kim, Yong Koo Park; Korean J Pathol. 2006;40(4):314-317.

2,029 View
21 Download

Abstract PDF: Primary osteosarcoma of the skull is a rare finding. We report here on a pathologically proven case of osteosarcoma that presented as a painless mass in the frontal bone of a 7-year-old boy. This unusual form of osteosarcoma had features of desmoplastic fibroma in a large portion of the tumor. We also include a review of the medical literature related to osteosarcoma.

Original Article

Immunohistochemical Sdtudy of Cytokeratin and Epithelial Membrane Antigen Expression in Osteosarcoma.: Jong Yup Bae, Mee Yon Cho, Soon Hee Jung; Korean J Pathol. 1996;30(10):920-927.

2,843 View
40 Download

Abstract PDF: Immunohistochemical analysis of 24 paraffin-embedded osteosarcomas was studied to evaluate the expression of simple cytokeratin, basal cytokeratin and epithelial membrane antigen(EMA) according to the histologic subtypes and anatomical locations. Mean age of the patients was 18 years. Anatomical locations of the tumors were femur(8), tibia(10), humerus(4), lumbar spine(1), and zygomatic arch(1). Histologic subtypes included osteoblastic(14), fibroblastic(4), chondroblastic(4), epithelioid(1), and mixed osteoblastic and fibroblastic(1). All were positive in the immunohistochemical stain for vimentin. The expression of cytokeratin and/or EMA was found in 10 cases(41.7%) regardless of anatomical locations and histologic subtypes. Positive immunoreaction for EMA was demonstrated in osteoblastic(5), chondroblastic(2), epithelioid(1), and mixed osteoblastic and fibroblastic(1) types. Osteoblastic (2), chondroblastic(2), and epithelioid(1) types among them also showed immunoreactivity with anti-simple cytokeratin monoclonal antibody, NCL-5D3. The expression of basal cytokeratin (NCL-LL002) was found in two osteoblastic, one chondroblastic, one epithelioid, and one mixed osteoblastic and fibroblastic types. These findings indicate that cytokeratin and EMA immunoreactivity can not be regarded as an absolute specific marker of the epithelial origin of tumor and may also occur in osteosarcoma.

Case Reports

Extraskeletal Osteosarcoma: A case Report.: Gi Yeong Huh, Sun Kyung Lee; Korean J Pathol. 1988;22(4):489-494.

1,747 View
12 Download

Abstract PDF: We report a case of extraskeletal osteosarcoma in view of rarity, and a brief review of the literature related to this type of tumor is presented. The patient was a 31-year-old Korean woman, who had noticed a bean-sized hard mass in the right thigh progressively enlarged to become egg-size during about 7 months, followed by pain and tenderness. There was neither recognizable previous lesion nor causable agent about the mass on history taking. Physical examination revealed another palpable mass on the inguinal area. The right thigh and inguinal masses were simply excised and histologically confirmed to be an extraskeletal osteosarcoma and metastatic one, respectively.

Primary Osteosarcoma of the Breast: A case report.: Dong Chool Kim, Yun Kyung Lee, Ho Jong Jeon, Sung Chul Lim; Korean J Pathol. 2000;34(9):677-679.

2,062 View
15 Download

Abstract PDF: We report a case of primary osteosarcoma of the breast which is rare and exhibits poor prognosis. A 52 years-old-woman was admitted with rapidly growing right mammary mass. A huge lobulated dense mass with speckled calcifications, suggesting malignancy, was observed on mammography. She underwent a radical mastectomy. Grossly, the mass measured 16 14 6 cm and showed grayish white hard lobulated tissue with focal hemorrhage and necrosis. Light microscopically, the tumor was confirmed as an osteosarcoma devoid of any epithelial components. In postoperative whole body bone scan, there was no evidence of the other malignancy. To the best of our knowledge, the present case is the first report of primary osteosarcoma of the breast in Korea.

Sarcomatoid Carcinoma with Heterologous Osteosarcomatous Component of the Prostate: A case report.: Eun Sun Jung, Young Jin Choi, Seok Jin Kang, Byung Gee Kim, Sun Moo Kim, Sang In Shim; Korean J Pathol. 1996;30(12):1144-1149.

2,218 View
18 Download

Abstract PDF: Sarcomatoid carcinoma of prostate has been rarely reported and occasionally difficult to distinguish from a true sarcoma or carcinosarcoma. A case of sarcomatoid carcinoma of the prostate, which has been occured in 61-year-old male patient is presented. The tumor consists of carcinomatous areas with epithelioid cells, sarcomatoid areas with spindle cells and foci of heterologous osteosarcoma component. The phenotypic nature of the tumor was confirmed immunohistochemically by positive reaction for cytokeratin, epithelial membrane antigen, vimentin and prostate specific acid phosphatase in both sarcomatous and carcinomatous components.

Parosteal Ossifying Lipoma of Femur: A Case Report.: Jae Seok Lee, Wan Hyung Cho, Ji Yoong Yu, Min Suk Kim, Jae Soo Koh; Korean J Pathol. 2007;41(2):123-126.

2,082 View
30 Download

Abstract PDF: Parosteal lipoma is a rare and generally asymptomatic benign tumor of mature adipose tissue that is located in direct apposition to the external surface of the bone. These tumors are occasionally associated with reactive changes in the underlying bone. The reactive bone formation is generally restricted to the base of the tumor, that is, near the periosteum. We recently experienced a case of parosteal lipoma in the proximal femur, which displayed exuberant bone and cartilage formation, and this led us to a misdiagnosis of chondroblastic osteosarcoma on the initial biopsy. We report here on this case with a special emphasis on making the differential diagnosis from osteosarcoma.

First
Prev
Page of 1
Next
Last

Search