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A review of liver fibrosis and cirrhosis regression
Michael J. Lee
J Pathol Transl Med. 2023;57(4):189-195.   Published online June 20, 2023
DOI: https://doi.org/10.4132/jptm.2023.05.24
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AbstractAbstract PDF
Cirrhosis has traditionally been considered an irreversible process of end-stage liver disease. With new treatments for chronic liver disease, there is regression of fibrosis and cirrhosis, improvement in clinical parameters (i.e. liver function and hemodynamic markers, hepatic venous pressure gradient), and survival rates, demonstrating that fibrosis and fibrolysis are a dynamic process moving in two directions. Microscopically, hepatocytes push into thinning fibrous septa with eventual perforation leaving behind delicate periportal spikes in the portal tracts and loss of portal veins. Obliterated portal veins during progressive fibrosis and cirrhosis due to parenchymal extinction, vascular remodeling and thrombosis often leave behind a bile duct and hepatic artery within the portal tract. Traditional staging classification systems focused on a linear, progressive process; however, the Beijing classification system incorporates both the bidirectional nature for the progression and regression of fibrosis. However, even with regression, vascular lesions/remodeling, parenchymal extinction and a cumulative mutational burden place patients at an increased risk for developing hepatocellular carcinoma and should continue to undergo active clinical surveillance. It is more appropriate to consider cirrhosis as another stage in the evolution of chronic liver disease as a bidirectional process rather than an end-stage, irreversible state.

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    Tissue and Cell.2026; 98: 103200.     CrossRef
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    Egyptian Liver Journal.2026;[Epub]     CrossRef
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    Journal of Clinical Medicine.2026; 15(2): 757.     CrossRef
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    Egyptian Liver Journal.2026;[Epub]     CrossRef
  • The Dual-Faceted Role of Metal-Based Nanomaterials in Hepatic Fibrosis Therapy
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    International Journal of Nanomedicine.2026; Volume 21: 1.     CrossRef
  • Reply to the Letter on “Clinical implications of fibrosis marker dynamics after hepatitis C cure: insights from paired biopsies”
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    Journal of the Formosan Medical Association.2026;[Epub]     CrossRef
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    Physiology.2025; 40(1): 4.     CrossRef
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    Medicina.2025; 61(1): 88.     CrossRef
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    The Korean Journal of Pancreas and Biliary Tract.2025; 30(1): 10.     CrossRef
  • Impact of Weight Loss on Metabolic Dysfunction Associated Steatohepatitis and Hepatic Fibrosis
    Marina W. Takawy, Manal F. Abdelmalek
    Current Diabetes Reports.2025;[Epub]     CrossRef
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    Sathiyamoorthy Padmanaban, Ji-Won Baek, Sai Sahithya Chamarthy, Saipriya Chandrasekaran, Antony V Samrot, Vijayakumar Gosu, In-Kyu Park, Kamalakannan Radhakrishnan, Don-Kyu Kim
    Liver Research.2025; 9(2): 104.     CrossRef
  • Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes
    Ashok Kumar Sah, Mohd Afzal, Rabab H. Elshaikh, Anass M. Abbas, Manar G. Shalabi, Pranav Kumar Prabhakar, Asaad M. A. Babker, Fariza Tursunbaevna Khalimova, Velilyaeva Aliya Sabrievna, Ranjay Kumar Choudhary
    Life.2025; 15(5): 779.     CrossRef
  • Poly(I:C)-Stimulated Exosomes Mitigate Cholesterol-Induced Hepatic Fibrosis by Modulating the TGF-β/Smad3 Signal Transduction Pathway
    Shahla Asadizadeh, Parichehreh Yaghmaei, Nasim Hayati Roodbari, Azam Khedri
    Hepatitis Monthly.2025;[Epub]     CrossRef
  • The postbiotic ReFerm® versus standard nutritional support in advanced alcohol-related liver disease (GALA-POSTBIO): a randomized controlled phase 2 trial
    Johanne K. Hansen, Mads Israelsen, Suguru Nishijima, Sara E. Stinson, Peter Andersen, Stine Johansen, Camilla D. Hansen, Maximilian Joseph Brol, Sabine Klein, Robert Schierwagen, Frank Erhard Uschner, Karolina Sulek, Ida F. Villesen, Katrine P. Lindvig, K
    Nature Communications.2025;[Epub]     CrossRef
  • ADVANCING CURCUMIN APPLICATIONS IN HEPATOCELLULAR CARCINOMA: INSIGHTS INTO PHARMACOKINETICS, PHARMACODYNAMICS AND NANODELIVERY SYSTEMS
    RESHMA T. MATE, ANURADHA N. CHIVATE, NAMDEO R. JADHAV, NIRANJAN D. CHIVATE
    International Journal of Applied Pharmaceutics.2025; : 19.     CrossRef
  • Genetic Determinants of Apoptosis Regulate Liver Cirrhosis Risk: The FAS/FASL Polymorphism Connection in Iraqi Population
    Wisam Hindawi Hoidy, Ahmed Ghdhban Al-Ziaydi
    Indian Journal of Clinical Biochemistry.2025;[Epub]     CrossRef
  • Histological and Molecular Evaluation of Liver Biopsies: A Practical and Updated Review
    Joon Hyuk Choi
    International Journal of Molecular Sciences.2025; 26(16): 7729.     CrossRef
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    Sachin Sharma, Vijaya Prathigudupu, Carson Cable, Lia R. Serrano, Srilaxmi Nerella, Alina Chen, Ghmkin Hassan, Johnathon Lakins, Carlos Lizama Valenzuela, Tatsuya Tsukui, Roopa Ramamoorthi, Jae-Jun Kim, Holger Willenbring, Aras N. Mattis, Regan F. Volk, B
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    Journal of Medical Virology.2025;[Epub]     CrossRef
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    The Egyptian Journal of Internal Medicine.2024;[Epub]     CrossRef
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    Biomedicines.2024; 12(6): 1337.     CrossRef
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  • Multiomic predictors for regression of cirrhosis: Clinical implications and future directions
    Binghua Li, Decai Yu
    iLIVER.2024; 3(4): 100116.     CrossRef
  • Commonly encountered symptoms and their management in patients with cirrhosis
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    Frontiers in Medicine.2024;[Epub]     CrossRef
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    Cells.2023; 12(17): 2127.     CrossRef
  • Nutritional deficiency in patients with liver cirrhosis
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    Clinical nutrition and metabolism.2023; 4(4): 265.     CrossRef

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