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Original Article
- The Significance of MicroRNA Let-7b, miR-30c, and miR-200c Expression in Breast Cancers.
- Sung Min Chun, Hee Jung Park, Chul Hwan Kim, Insun Kim
- Korean J Pathol. 2011;45(4):354-360.
- DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.354
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Abstract
PDF - BACKGROUND
MicroRNA (miRNA) is a class of noncoding protein RNA as a promising biomarker for various diseases. In this study, the expression of let-7b, miR-30c, and miR-200c was studied in breast cancer tissues to evaluate the potential relationship with known clinicopathological parameters.
METHODS
Quantitative real-time polymerase chain reaction was performed to determine the expression level of three miRNAs in 37 pairs of noncancerous normal and cancer tissues and an additional 38 cancer tissues from patients with invasive ductal carcinoma.
RESULTS
miR-200c expression was higher in cancer tissues compared to noncancerous normal tissues, and its ratio was correlated with patient age at surgery, type of surgery, and Ki-67 expression. The expression level of let-7b in cancer tissues was inversely correlated with lymph node metastasis, histological grade, and Ki-67 expression but positively correlated with estrogen and progesterone receptor expression. miR-200c expression level was positively correlated with Her-2 expression. The miR-30c expression level in breast cancer was not correlated with any parameters.
CONCLUSIONS
miR-200c and let-7b could be used as biomarkers in patients with breast cancer, but its pathological mechanism should be determined. -
Citations
Citations to this article as recorded by
- Evaluating MicroRNAs as diagnostic tools for lymph node metastasis in breast cancer: Findings from a systematic review and meta-analysis
Coral González Martínez, Stavros Therapontos, Jose A. Lorente, Miriam Alcaide Lucena, F.Gabriel Ortega, M.Jose Serrano
Critical Reviews in Oncology/Hematology.2025; 207: 104598. CrossRef - High DRC Levels Are Associated with Let-7b Overexpression in Women with Breast Cancer
Jarline Encarnación, Carmen Ortiz, Ralphdy Vergne, Wanda Vargas, Domenico Coppola, Jaime Matta
International Journal of Molecular Sciences.2016; 17(6): 865. CrossRef
- Evaluating MicroRNAs as diagnostic tools for lymph node metastasis in breast cancer: Findings from a systematic review and meta-analysis
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