Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Radiologically, this tumor is characterized by a cortical topography and lack of mass effect or perilesional edema. Partial complex seizures are the most common presentation. Three histologic subtypes of DNTs have been described. Histologically, the recognition of a unique, specific glioneuronal element in brain tumor samples from patients with medically intractable, chronic epilepsy serves as a diagnostic feature for complex or simple DNT types. However, nonspecific DNT has diagnostic difficulty because its histology is indistinguishable from conventional gliomas and because a specific glioneuronal element and/or multinodularity are absent. This review will focus on the clinical, radiographic, histopathological, and immunohistochemical features as well as the molecular genetics of all three variants of DNTs. The histological and cytological differential diagnoses for this lesion, especially the nonspecific variant, will be discussed.
Citations
Citations to this article as recorded by
Pediatric Neuroglial Tumors: A Review of Ependymoma and Dysembryoplastic Neuroepithelial Tumor Melissa Arfuso, Sandeepkumar Kuril, Harshal Shah, Derek Hanson Pediatric Neurology.2024; 156: 139. CrossRef
From bedside to bench: New insights in epilepsy‐associated tumors based on recent classification updates and animal models on brain tumor networks Silvia Cases‐Cunillera, Lea L. Friker, Philipp Müller, Albert J. Becker, Gerrit H. Gielen Molecular Oncology.2024; 18(12): 2951. CrossRef
Imaging of pediatric glioneuronal and neuronal tumors Vivek Pai, Suzanne Laughlin, Birgit Ertl-Wagner Child's Nervous System.2024; 40(10): 3007. CrossRef
Dysembryoplastic Neuroepithelial Tumor: A Case Report of A Benign Intracranial Lesion Masquerading as Seizure Disorder Garima S Agarwal, Anil K Agrawal, Daksh Singhal, Jayashree Bhawani Cureus.2024;[Epub] CrossRef
Super T2-FLAIR mismatch sign: a prognostic imaging biomarker for non-enhancing astrocytoma, IDH-mutant Iori Ozono, Shumpei Onishi, Ushio Yonezawa, Akira Taguchi, Novita Ikbar Khairunnisa, Vishwa Jeet Amatya, Fumiyuki Yamasaki, Yukio Takeshima, Nobutaka Horie Journal of Neuro-Oncology.2024; 169(3): 571. CrossRef
Genotype-relevant neuroimaging features in low-grade epilepsy-associated tumors Keiya Iijima, Hiroyuki Fujii, Fumio Suzuki, Kumiko Murayama, Yu-ichi Goto, Yuko Saito, Terunori Sano, Hiroyoshi Suzuki, Hajime Miyata, Yukio Kimura, Takuma Nakashima, Hiromichi Suzuki, Masaki Iwasaki, Noriko Sato Frontiers in Neurology.2024;[Epub] CrossRef
Extra-temporal pediatric low-grade gliomas and epilepsy José Hinojosa, Victoria Becerra, Santiago Candela-Cantó, Mariana Alamar, Diego Culebras, Carlos Valencia, Carlos Valera, Jordi Rumiá, Jordi Muchart, Javier Aparicio Child's Nervous System.2024; 40(10): 3309. CrossRef
Atypical Presentation of Dysembryoplastic Neuroepithelial Tumor Varis S. Khalilov, Aleksey N. Kislyakov, Natalia A. Medvedeva, Natalia S. Serova Annals of Clinical and Experimental Neurology.2024; 18(3): 109. CrossRef
Unusual low-grade neuroepithelial tumour in a child Leia Salongo, Ali Nael, Pournima Navalkele, John Ross Crawford BMJ Case Reports.2024; 17(10): e262692. CrossRef
Glioneuronal and Neuronal Tumors: Who? When? Where? An Update Based on the 2021 World Health Organization Classification A.S. Ayres, G.A. Bandeira, S.F. Ferraciolli, J.T. Takahashi, R.A. Moreno, L.F. de Souza Godoy, Y.R. Casal, L.G.C.A. de Lima, F.P. Frasseto, L.T. Lucato Neurographics.2023; 13(1): 1. CrossRef
Biological functions of the Olig gene family in brain cancer and therapeutic targeting Jenny I. Szu, Igor F. Tsigelny, Alexander Wojcinski, Santosh Kesari Frontiers in Neuroscience.2023;[Epub] CrossRef
Aspekte der Bildgebung des Hippokampus Isabela S. Alves, Artur M. N. Coutinho, Ana Vieira, Bruno P. Rocha, Ula L. Passos, Vinicius T. Gonçalves, Paulo D. S. Silva, Malia X. Zhan, Paula C. Pinho, Daniel S. Delgado, Marcos F. L. Docema, Hae W. Lee, Bruno A. Policeni, Claudia C. Leite, Maria G. M Neuroradiologie Scan.2023; 13(03): 197. CrossRef
T2-FLAIR Mismatch Sign in Pediatric Low-Grade Glioma M.W. Wagner, L. Nobre, K. Namdar, F. Khalvati, U. Tabori, C. Hawkins, B.B. Ertl-Wagner American Journal of Neuroradiology.2023; 44(7): 841. CrossRef
Clinicopathological features of dysembryoplastic neuroepithelial tumor: a case series Shabina Rahim, Nasir Ud Din, Jamshid Abdul-Ghafar, Qurratulain Chundriger, Poonum Khan, Zubair Ahmad Journal of Medical Case Reports.2023;[Epub] CrossRef
Imaging Aspects of the Hippocampus Isabela S. Alves, Artur M. N. Coutinho, Ana P. F. Vieira, Bruno P. Rocha, Ula L. Passos, Vinicius T. Gonçalves, Paulo D. S. Silva, Malia X. Zhan, Paula C. Pinho, Daniel S. Delgado, Marcos F. L. Docema, Hae W. Lee, Bruno A. Policeni, Claudia C. Leite, Mari RadioGraphics.2022; 42(3): 822. CrossRef
Dysembryoplastic neuroepithelial tumors: A single-institutional series with special reference to glutamine synthetase expression Chiara Caporalini, Mirko Scagnet, Selene Moscardi, Gioia Di Stefano, Gianna Baroni, Flavio Giordano, Federico Mussa, Carmen Barba, Iacopo Sardi, Lorenzo Genitori, Anna Maria Buccoliero Annals of Diagnostic Pathology.2021; 54: 151774. CrossRef
Unusual case of occipital lobe dysembryoplastic neuroepithelial tumour withGNAi1-BRAFfusion Jennifer H Yang, Denise M Malicki, Michael L Levy, John Ross Crawford BMJ Case Reports.2021; 14(1): e241440. CrossRef
Malformations of Cortical Development, Cognitive Involvementand Epilepsy: A Single Institution Experience in 19 Young Patients Valeria Venti, Maria Chiara Consentino, Pierluigi Smilari, Filippo Greco, Claudia Francesca Oliva, Agata Fiumara, Raffaele Falsaperla, Martino Ruggieri, Piero Pavone Children.2021; 8(8): 637. CrossRef
A Case of Dysembryoplastic Neuroepithelial Tumor in an Adolescent Male Marcel Yibirin, Diana De Oliveira, Isabella Suarez, Gabriela Lombardo, Carlos Perez Cureus.2021;[Epub] CrossRef
Clinical and histopathological profile of dysembryoplastic neuroepithelial tumor Pooja Gupta, Fouzia Siraj, Akanksha Malik, K. B. Shankar Journal of Cancer Research and Therapeutics.2021; 17(4): 912. CrossRef
Neuroradiological and pathomorphological features of epilepsy associated brain tumors V. S. Khalilov, A. A. Kholin, A. N. Kisyakov, N. A. Medvedeva, B. R. Bakaeva Diagnostic radiology and radiotherapy.2021; 12(2): 7. CrossRef
Evaluación prequirúrgica mediante resonancia magnética funcional en pacientes con tumores neuroepiteliales disembrioplásicos: una serie de casos Natalia García-Casares, Francisco Alfaro-Rubio, José Ramón Ramos-Rodríguez, Álvaro Ocaña-Ledesma, Bernarda Márquez-Márquez, Victoria E. Fernández-Sánchez, Guillermo Ibáñez-Botella, Miguel Ángel Arráez-Sánchez, Pedro J. Serrano-Castro Neurocirugía.2020; 31(4): 158. CrossRef
Features of the neuroradiological picture of ganglioglioma on the example of 20 clinical cases V.S. Khalilov, A.A. Kholin, Kh.Sh. Gazdieva, A.N. Kislyakov, N.N. Zavadenko Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2020; 120(11): 90. CrossRef
Malignant Glial Neuronal Tumors After West Nile Virus Neuroinvasive Disease: A Coincidence or a Clue? Akanksha Sharma, Marie F. Grill, Scott Spritzer, A. Arturo Leis, Mark Anderson, Parminder Vig, Alyx B. Porter The Neurohospitalist.2019; 9(3): 160. CrossRef
Particularities in differential diagnostics of epileptogenic brain malformations on the low-field MRI-device V. S. Khalilov, A. A. Kholin, B. R. Bakaeva, M. Yu. Bobylova, Kh. Sh. Gazdieva Russian Journal of Child Neurology.2019; 13(4): 23. CrossRef
Dysembryoplastic Neuroepithelial Tumors: What You Need to Know Sabino Luzzi, Angela Elia, Mattia Del Maestro, Samer K. Elbabaa, Sergio Carnevale, Francesco Guerrini, Massimo Caulo, Patrizia Morbini, Renato Galzio World Neurosurgery.2019; 127: 255. CrossRef
The miR‐139‐5p regulates proliferation of supratentorial paediatric low‐grade gliomas by targeting the PI3K/AKT/mTORC1 signalling G. Catanzaro, Z. M. Besharat, E. Miele, M. Chiacchiarini, A. Po, A. Carai, C. E. Marras, M. Antonelli, M. Badiali, A. Raso, S. Mascelli, D. Schrimpf, D. Stichel, M. Tartaglia, D. Capper, A. von Deimling, F. Giangaspero, A. Mastronuzzi, F. Locatelli, E. Fe Neuropathology and Applied Neurobiology.2018; 44(7): 687. CrossRef
Dysembryoplastic Neuroectodermal Tumor: An Analysis from the Surveillance, Epidemiology, and End Results Program, 2004–2013 Ha Son Nguyen, Ninh Doan, Michael Gelsomino, Saman Shabani World Neurosurgery.2017; 103: 380. CrossRef
Common Histologically Benign Tumors of the Brain Roy E. Strowd, Jaishri O. Blakeley CONTINUUM: Lifelong Learning in Neurology.2017; 23(6): 1680. CrossRef