Journal of Pathology and Translational Medicine

Review

Primary Age-Related Tauopathy: An Elderly Brain Pathology Frequently Encountered during Autopsy: Daru Kim, Hyung-Seok Kim, Seong-Min Choi, Byeong C. Kim, Min-Cheol Lee, Kyung-Hwa Lee, Jae-Hyuk Lee; J Pathol Transl Med. 2019;53(3):159-163. Published online March 19, 2019; DOI: https://doi.org/10.4132/jptm.2019.03.14

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Due to the progressive aging of Korean society and the introduction of brain banks to the Korean medical system, the possibility that pathologists will have access to healthy elderly brains has increased. The histopathological analysis of an elderly brain from a subject with relatively well-preserved cognition is quite different from that of a brain from a demented subject. Additionally, the histology of elderly brains differs from that of young brains. This brief review discusses primary age-related tauopathy; this term was coined to describe elderly brains with Alzheimer’s diseasetype neurofibrillary tangles mainly confined to medial temporal structures, and no β-amyloid pathology.

Citations

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Case Report

Alzheimer's Disease: Report of two cases.: Hee Sung Kim, Yeon Lim Suh, Kyung Sue Hong, Duk Lyul Na; Korean J Pathol. 1997;31(2):167-173.

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Abstract PDF: Alzheimer's disease (AD) is the most common etiology of dementia, that has not been previously reported in Korea. We have experienced two cases of Alzheimer's disease, one occurred in a 53-year-old man with dementia and the other occurred in a 36-year-old woman with a family history of early onset dementia. A neocortical biopsy was done to rule out the cause of dementia and showed diffusely scattered numerous senile plaques and neurofibrillary tangles in cortex of both cases. Interestingly, GFAP, an immunohistochemical stain showed strong positivity in neuritic plaques and the surrounding fibrillary gathering.

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