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- Concurrent intestinal plasmablastic lymphoma and diffuse large B-cell lymphoma with a clonal relationship: a case report and literature review
- Nao Imuta, Kosuke Miyai, Motohiro Tsuchiya, Mariko Saito, Takehiro Sone, Shinichi Kobayashi, Sho Ogata, Fumihiko Kimura, Susumu Matsukuma
- J Pathol Transl Med. 2024;58(4):191-197. Published online June 25, 2024
- DOI: https://doi.org/10.4132/jptm.2024.05.14
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- 2 Web of Science
- 2 Crossref
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Abstract
PDF - Herein, we report a case of plasmablastic lymphoma (PBL) and diffuse large B-cell lymphoma (DLBCL) that occurred concurrently in the large intestine. An 84-year-old female presented with a palpable rectal tumor and ileocecal tumor observed on imaging analyses. Endoscopic biopsy of both lesions revealed lymphomatous round cells. Hartmann’s operation and ileocecal resection were performed for regional control. The ileocecal lesion consisted of a proliferation of CD20/CD79a-positive lymphoid cells, indicative of DLBCL. In contrast, the rectal tumor showed proliferation of atypical cells with pleomorphic nuclei and abundant amphophilic cytoplasm, with immunohistochemical findings of CD38/CD79a/MUM1/MYC (+) and CD20/CD3/CD138/PAX5 (–). Tumor cells were positive for Epstein-Barr virus– encoded RNA based on in situ hybridization and MYC rearrangement in fluorescence in situ hybridization analysis. These findings indicated the rectal tumor was most likely a PBL. Sequencing analysis for immunoglobulin heavy variable genes indicated a common B-cell origin of the two sets of lymphoma cells. This case report and literature review provide new insights into PBL tumorigenesis.
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Citations
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- Rectal diffuse large B-cell lymphoma misdiagnosed as bleeding cancer in an elderly patient
Yuchun Zhong, Qiansen Zhang, Yujie Fu, Jiusi Liu, Linhui Leng, Wei Xu
Discover Oncology.2026;[Epub] CrossRef - Case Report: Clonal evolution of diffuse large B-cell lymphoma to plasmablastic lymphoma: diagnostic challenges in a case of gastric lesion with EBV-negative PBL
Jie Xu, Yueli Liu, Xi Feng, Dejie Zhao, Kui Liu, Siyuan Cui, Yan Wang
Frontiers in Oncology.2026;[Epub] CrossRef
- Rectal diffuse large B-cell lymphoma misdiagnosed as bleeding cancer in an elderly patient
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