Journal of Pathology and Translational Medicine

Review Article

Basaloid Squamous Cell Carcinoma of the Upper Aerodigestive Tract.: Kyung Ja Cho; Korean J Pathol. 2010;44(1):1-8.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.1.1

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Basaloid squamous cell carcinoma (BSCC) is an uncommon variant of squamous cell carcinoma (SCC), usually occurring in the larynx, hypopharynx, oropharynx and esophagus. BSCCs have been reported from various geographic areas, but esophageal BSCCs are more prevalent in Asia. The morphology of BSCC is quite characteristic, but BSCC occasionally needs to be differentiated from neuroendocrine carcinoma or adenoid cystic carcinoma. Human papillomavirus16-associated oropharyngeal SCC with poorly differentiated or basaloid features has recently been recognized as a new clinical entity with a different etiology and prognosis. Nonoropharyngeal BSCC appears to share etiologic factors, genetic alterations and an immunoprofile with conventional SCC of the upper aerodigestive tract. However, the divergent differentiation of BSCC into various non-basaloid, epithelial or mesenchymal elements suggests the participation of more mulipotential cells than in SCC. The biologic behavior of BSCC has been reported to be worse than or equal to that of SCC, yet the data including the increasing numbers of human papillomavirus-associated cases now require reanalysis. It is presently uncertain whether BSCC is a histogenetically or clinically unique disease entity.

Citations

Citations to this article as recorded by

Liver metastatic basaloid squamous cell carcinoma with negative expression of pancytokeratin: a case report and literature review
Linxiu Liu, Xuemin Xue, Liyan Xue
Diagnostic Pathology.2019;[Epub] CrossRef
A Case of Basaloid Squamous Cell Carcinoma of Rectosigmoid Colon
Tae Hwan Ha, Tae Joo Jeon, Ji Young Park, Yong Ho Jang, Deok Hee Kim, Mi Jin Ryu, Dong Hyun Sinn, Tae Hoon Oh
The Korean Journal of Gastroenterology.2013; 62(6): 375. CrossRef

Original Article

Infantile Myofibromatosis(Congenital Generalized Fibromatosis): Associated with multiple congenital malformations and basaloid follicular hamartomas in the skin.: Eun Sook Nam, Yoo Hun Kim, Han Kyeom Kim, Insun Kim, Je Geun Chi; Korean J Pathol. 1995;29(6):776-782.

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Abstract PDF: Infantile myofibromatosis with systemic involvement is a very rare disease and is characterized by numerous nodules composed of spindle cells of a myofibroblastic nature. There are often disseminated throughout the subcutis, muscle, skeleton and viscera. We report an autopsy case of infantile myofibromatosis in a stillborn female fetus of 32 weeks of gestation. The nodules, Imm to 2 cm, were found over the whole body and viscera. The involved viscera were the heart, tongue, esophagus, gastrointestinal tract, portal areas of the liver, spleen anc pancreas. There were also associated malformations, viz., frontal meningoencephalocele, flexion defer-mities, syndactyly, cleft palate, agenesis of corpus callosum, pachygyria, diaphragmatic hemia, renal hypoplasia, etc. Multiple basaloid follicular hamartomas of the skin were noted on the face and extremeties. There are no previous reports in the literature of infantile myofibromatosis in conjunction with the above skin lesion and congenital malformations.

Case Report

Cutaneous Lymphadenoma: A case report and Review of Literature.: Im Joong Yoon, Mee Kyung Kim, Kye Yong Song; Korean J Pathol. 1998;32(4):309-311.

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Abstract PDF: The cutaneous lymphadenoma is a recently described tumor with a distinctive histologic picture representing a basaloid epithelial proliferation and intraepithelial lymphocytic infiltration; it seems to be a benign adnexal neoplasm of uncertain histogenesis. We documented one example of cutaneous lymphadenoma showing typical histologic features. The tumor typically presented as a well circumscribed nodule with scant or no epidermal connections. The proliferating one consisted of multiple rounded lobules of basaloid cells with some degree of peripheral palisading. There was an intense infiltrate of small lymphocytes within the lobules but few in the stroma. No clear adnexal differentiation is noted. Immunohistochemically, the basaloid cells show weak immunoreactivity for high molecular weight keratin and carcinoembryonic antigen, small lymphocytes for T-cell marker and some dendritic cells for S-100 protein. After surgical resection, we found no evidence of local recurrence or distant metastasis for four years, so we considered this tumor as a benign one and diagnosed as cutaneous lymphadenoma by typical histologic features.

Original Article

Fine Needle Aspiration Cytology of Pilomatrixoma: A Report of Five Cases.: Ho Sung Park, Myoung Ja Chung, Myoung Jae Kang, Dong Geun Lee; Korean J Cytopathol. 2000;11(1):53-58.

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Abstract PDF: Pilomatrixoma is a benign tumor which usually occur as a solitary, firm nodule in the head and neck, and upper extremities of young people. This tumor is occasionally encountered during aspiration biopsy of subcutaneous masses, but only a small number of cases are correctly diagnosed prior to excision. We report five cases of pilomatrixoma. Four cases occurred in the neck and one case in the back. The characteristic fine needle aspiration cytologic features are shadow cells and basaloid cells in the background of inflammatory cells, including some multinucleated giant cells. The shadow cells were recognized in all five cases. These cells were pale, anucleated cells with relatively distinct cell borders. May-Gr nbald-Giemsa stain is useful for the identification of shadow cells. The recognition of shadow cells appears to be essential for accurate diagnosis of pilomatrixoma.

Review

Cytologic Diagnosis of Basaloid Neoplasms of Salivary Gland.: Kyung Ja Cho; Korean J Cytopathol. 2005;16(2):67-74.

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Abstract PDF: Although fine needle aspiration cytology (FNAC) has become one of the primary tools for diagnosing salivary gland lesions, some of these methods continue to confuse pathologists. The most common problems occur so-called basaloid neoplasms. Basal cell adenomas are frequently misdiagnosed as pleomorphic adenomas, and in worse cases, as adenoid cystic carcinomas. The cytologic diagnostic accuracy of basaloid neoplasms could be increased by a better understanding of the histology and the nature of the tumor cells. These are displayed well in aspiration smears. A consideration of differential points on the basis of the epithelial-stromal relationship is offered in this paper.

Case Report

Basaloid-Squamous Carcinoma of the Esophagus: A case report.: Tae Jung Jang, In Joon Choi; Korean J Pathol. 1992;26(1):96-98.

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Abstract PDF: Basaloid-squamous carcinoma of the esophagus is rare and similiar to the solid type of adenoid cystic carcinoma of the salivary gland. The origin of this tumor is unknown. The tumor was located in the lower third of the esophagus. The case of basaloid-squamous carcinoma consisted of submucosal tumor showing carcinoma with a basaloid pattern and focal squamous differentiation associated with squamous cell carcinoma or carcinoma in situ of the esophageal mucosa. A few submucosal tumor cells were positive for cytokeratin.

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