Journal of Pathology and Translational Medicine

Volume 10(2); November 1976

Etcs

Vascular Changes in Congenital and Acquired Heart Diseases, Studied in Lung Biopsies of Koreans: Eui Keun Ham, Hyun Soon Lee; J Pathol Transl Med. 1976;10(2):181-188.

1,387 View
10 Download

Abstract: Histopathological investigation of lung biopsies on pulmonary vascular changes from 68 patients with congenital heart diseases and 58 with acquired heart diseases were made. Used specimens were examined at the Department of Pathology, College of Medicine, Seoul National University, during a period of 10 years from 1965 to 1974. The progression of vascular changes in lung biopsies were so stereotyped as to allow a division of structural effects into six grades regarding as Heath and Edwards method. Author observed various gradational changes of pulmonary vascular lesions, ranging from almost normal looking to marked medial hypertrophy with intimal fibrosis and plexiform or angiomatous dilatation lesions. Intimal fibrosis was thought to be based on organization of thrombi. One case of necrotizing angitis was revealed in a patient with patent ductus arteriosus. Severity of pulmonary vascular lesions of lung biopsies from patient with acquired heart diseases was more prominent than those from patient with congenital heart diseases. And no particular relationships to sex was made from both groups of heart diseases, but age had statistically significant relationship to those severity especially inpatient group with congenital heart diseases (r=0.39, p<0. 01).

Progressive Multifocal Leukoencephalopathy: Je G. Chi; J Pathol Transl Med. 1976;10(2):191-198.

1,591 View
10 Download

Abstract: Based on two autopsy materials a brief review on progressive multifocal leukoencephaopathy was made, with special emphasis on its neuropathological findings and pathogenesis. The importance of recognizing this primarily demyelinating illness of viral etiology is emphasized, particularly in view of its potential epidemiological significance.

Effect of DPH(Diphenylhydantoin) to RBC Osmotic Fragility of Normal Person: Yung Heon Lee, Jae Soong Kim, Jae Sik Kim, Jung Myung Kim; J Pathol Transl Med. 1976;10(2):199-202.

1,359 View
10 Download

Abstract: The authors investigated the effects of DPH to the RBC osmotic fragility of normal person in vitro and obtained the result as follows : The usual doses, 20 ug of DPH, were added to four persons’ RBC suspension in various concentration of buffered NaCl in orders and divided evenly in half respectively, the one for incubation at 37℃ and the other for control omitting the incubation. There was noted a remarkable decrease in the RBC osmotic fragility with incubation comparing to the decrease in the RBC osmotic fragility without incubation.

Study on Serum Alpha-Fetoprotein and Hepatitis-associated Antigen in Patients with Primary Hepatoma: Yung Heon Lee, Jae Sik Kim, Jyung Myung Kim; J Pathol Transl Med. 1976;10(2):203-209.

1,681 View
10 Download

Abstract: Alpha-fetoprotein (AFP) and hepatitis-associated antigen (HAA) have been checked by the method of agarose gel immunodiffusion with 303 Korean patients including 79 patients of primary hepatoma, 169 patients of miscellaneous liver diseases, 25 cases of extrahepatic malignant tumor, and 30 normal persons for the recent two years from July 1974 to June 1976 and the results are as follows. 1. AFP was positive in 46 of 79 cases (58.2%) with primary hepatoma, 2 of 92 cases with liver cirrhosis, and 1 of two neonatal hepatitis. 2. The occurrence of HAA in patients with primary hepatoma is 18 of 76 cases (23.6%) 3. AFP positive cases in hepatomas showed positive HAA in 15 of 51 (29.1%) and AFP negative cases showed 3 of 25 (12.0%) respectively. The frequency of HAA positive in hepatomas seemed to be higher in AFP positive cases than AFP negative. 4. The primary hematoma showed a tendency of higher incidence of AFP positivity in young age group than elderly persons.

Korea Native Phytagglutinin Arisaema amurense Maximowicz induced Agglutinations of Normal and Tumor Cells: Gook Jin Moon, Seung Yong Paik*, Bong Hee Lee, Chul Soo Lee; J Pathol Transl Med. 1976;10(2):211-221.

2,298 View
10 Download

Abstract: A previous study demonstrated that animal erythrocytes such as horse, dog, rabbit and rat were agglutinated by the saline extracts of Arisaema amurense Maximowicz (AAM) while human erythrocytes were not by one of authors (Moon). In the present experiments, normal cells such as human erythrocytes, leukocytes, lung, liver, spleen, kidney, heart, stomach, adrenal gland and urinary bladder cells were suspended in 0.1% EDTA solution and tumor cells such as acute & chronic myelocytic leukemia, acute lymphocytic leukemia, lung cancer, urinary bladder cancer, mice leukemia cells and leukocytes of multiple myeloma patients were suspended in 0.1% EDPA solution and performed agglutination test with AAM phytagglutinin which were extracted by various solvents such as saline, ammonium sulfate(AS ; 45%, 75% and 85% solution) and perchloric acid (PA : 0.45M, 0.75M and 1.5M solution). The effects of the saliva and sugars on agglutination inhibition were studied as well in the present paper with the following results. Normal cells were not agglutinated by AAM saline extracts while some of non leukemia patient’s leukocytes were agglutinated by AS an4 PA extracts. Tumor cells used in this experiment were highly susceptible to agglutination by AAM extracts in order PA, AS and saline extracts. AAM saline and AS extracts induced agglutination of tumor cells were inhibited by D-galactose and PA extracts were by L-fucose. All kinds of AAM extracts such as saline AS and PA induced agglutinations of tumor cells were inhibited by some human saliva and some were not and it was not related with secrete form and blood groups of saliva. These results indicate that AAM agglutinability by various extraction emphasizes the importance of examining a wide variety of cells in attempting to understand the interactions of PHA with an cell surface and AAM extracts are more useful than con-A and wheat germ agglutinin to study for cellular surface recept sites of tumor cells.

Studies on Eosinophils : Bone Marrow Eosinophilia: K. Y. Maeng, H. I. Cho, S. I. Kim; J Pathol Transl Med. 1976;10(2):223-229.

1,702 View
10 Download

Abstract: 39 bone marrow eosinophilia cases which showed more than 10% of eosinophils in marrow differential counts were analyzed according to etiology. Mean valuers of eosinophils in differential count of these cases were 17.5±9.5% in bone marrow and 23.7±16.4% in peripheral blood. Mean of absolute eosinophil counts of peripheral blood was 5,788/cmm. Other hematologic values were not so significant except moderate anemia (mean Hb value, 10.7gm/dl) and leucocytosis (18,700/cmm). Clinical diagnosis and bone marrow findings were parasitic infestations in 12 cases (31%), lymphoma in 4 cases(10%), other blood dyscrasias in 6 crises(15%), eosinophilia associated with liver diseases in 4 cases(10%), dermatologic diseases in 2 cases(5%), allergic conditions in 2 cases(5%), malignant diseases in 3 cases(8%), undetermined etiology in 2 eases(5%), varicose vein in 1 case, Raynaud disease in 1 case, dwarfism in 1 case and cryptococcosis in 1 case. Degrees of eosinophilia in marrow differential count were 10∼19% in 26 cases, 20∼ 29% in 8 cases, 30∼39% in 3 cases, and more than 40% in 2 cases, while absolute eosinophil counts in peripheral blood were less than 500/cmm in 3 cases, 500∼2000/cmm in 11 cases, 2000∼5000/cmm in 7 cases, 5000∼10000/cmm in 6 cases and more than 10000/cmm in 6 cases. In cases of parasitic infestations, there were clonorchiasis in 3 cases, ascariasis in 3 cases, hook worm disease in 3 cases, trichocephaliasis in 2 cases and combined infestation of hook worm, trichuris trichura, clonorchis sinensis and paragonimus westermani in 1 case. In cases of blood dyscrasias, there were malignant lymphoma in 4 cases. In comparison with our previous report, cases of portal hypertension are decreased, while parasitic infestations and 1ymphoma cases are markedly increased.

Analysis of Technical Errors in Clinical Chemistry: Jae Sik Kim, Jyung Myung Kim, Han Ik Cho*, Sang In Kim*, Yong Hee Choi**, Kye Neung Lee***, Samuel Lee***; J Pathol Transl Med. 1976;10(2):231-240.

1,362 View
10 Download

Abstract: At present, the demand of clinical biochemisty has increased because the highly developed clinical medicine requires a very strong scientific basis to establish correct diagnosis, treatment and evaluation of the progress of patient. Clinical Chemistry lab seems to be the most important nucleus of laboratory functions in accordance with the tremendous increases in both bulk and kinds of the test requested. However it is still difficult to perform satisfactory biochemical tests with accuracy and precision due to the errors during daily procedures. With the world wide quality control system applies to clinical biochemistry, it is still not so satisfactory in Korea. There might be a number of factors bringing errors in biochemical determination including sample process, glassware and instrument, reagent, standard solution, and personal technic etc. We made, a rough survey, to detect the causes of errors, mainly with pipet, photometer, densitometer and personal technic and the followings are the findings with tables and figures accompanying.

A Study on Pseudomonas Aeruginosa: Jin Tae Suh, Sang In Kim, Han Ik Cho, Jung Ik Suh; J Pathol Transl Med. 1976;10(2):241-245.

1,034 View
10 Download

Abstract: The 294 cases of Pseudomonas aeruginosa isolated at S.N.U.H. during a period of 18 months from January 1975 to June 1976 were analyzed on the age and sex of patients, sources of specimens, species and frequency of mixed micro-organisms, and the results of antibiotic sensitivity test. The following results and conclusions were made. 1) Ratio of male to female patients was 7.1 ; 2.9, average age of patient is 39 year-old. There were 9 patients over 70 year-old and 4 patients less than one year old. 2) Source of specimens were ; 113 cases of pus (38%), 68 cased of urine(23%), 48 cases of sputum (16%), 35 cases of bronchial aspiration(12%), 9 cases of blood cultures (3%), and others 14 cases (5%). 3) Frequencies of mixed microorganisms were ; 40 cases of coliform bacilli, 28 cases of non-sugar fermenting microorganism (5 groups in TSI reaction), 27 cases of Klebsiella, 16 cases of Coagulase (+)Staphylococcus, 15 cases of paracolon bacilli, 11 cases of Proteus species, 9 cases of E coli, and 25 cases other microorganisms. 4) Frequencies of single or mixed microorganism isolation were ; Pseudomonas aeruginosa alone : 159 cases, one species mixed : 113 cases, two species mixed : 18 cases, and three species mixed : 4 cases. 5) Monthly or seasonal frequency in isolation rate was not demonstrated. 6) In the antibiotic sensitivity test, Pseudomonas aeruginosa was sensitive to only gentamicin.

Histiocytic Medullary Reticulosis (Report of Two Cases): O. J. Paik, C. C. Cho, S. K. Moon; J Pathol Transl Med. 1976;10(2):247-254.

1,362 View
10 Download

Abstract: Two cases of histiocytic medullary reticulosis occurring in an 18 years old male and a 14 years old female were presented with discussion of their clinicopathologic characteristics and brief literature review, and the latter was verified with autopsy. Although the cutaneous lesions were much more prominent in our cases, the clinical symptoms and signs, rapid fatal course, and hematological features were basically identical to those of previously documented histiocytic medullary reticulosis. On autopsy, the lesions were found to be systemic and showed diffuse proliferation of the atypical hitiocytes engaged in active phagocytosis. Liver, spleen, Iymph nodes, and bone marrow were mainly involved, but the other tissues, such as skin, lungs, brain, kidneys, thyroid, adrenal capsule, pericardium, and thoracic wall, were considerably affected as well.

A Case of Sacrococcygeal Endodermal Sinus Tumor: Ok Sun Rhee, Yoo Bock Lee, Bong Yong Lee*, Eui Ho Whang*, Kyu Chul Whang*; J Pathol Transl Med. 1976;10(2):255-259.

1,346 View
10 Download

Abstract: Endodermal sinus tumor is a rare neoplasm and microscopically characterized by a glomerulus-like structures. It was first described by Schiller in 1939 under the designation of mesonephroma because of microscopic structures resembling mesonephric glomeruli. Kazancigil et al.(1940), however, considered the glomerulus-like structures to be papillary and endothelial in nature and do not represent attempted formations of true glomeruli. Teilum(1952, 1965) observed similarity between papillary formations in the rat placenta and this tumor of human ovary. These papillary structures in the rat had been called endodermal sinuses by Duval (1891) because he considered them to represent diverticula of the yolk sac growing into extraembrynoic mesenchyme. Endodermal sinus tumor hag generally been reported to be in the ovary and testis and often in association with teratomatous areas. Very few cases of endodermal sinus tumor originating from extragonadal sites such as anterior mediastinum, pelvis, pineal gland have been described. In 1964, Rao et al. first reported the endodermal sinus tumor of sacrococcygeal area from a 3 years old girl under the title of sacrococcygeal mesonephroma. Our case is a 4 year old girl and complained pain and slow glowing mass of sacrococcygeal area for 2 months. Except for a palpable mass at sacrococcyx, all other physical examinations were negative including pelvic organs. Barium enema showed soft increased mass shadow in the buttock and somewhat increased presacral or retrorectal space. No evidence of bone destruction in the sacrum is noted. Excision of the mass was performed. Histologic examination revealed the typical picture of sinus tumor without the evidence of teratomatous component. Since there was no evidence of ovarian involvement, the lesion was regarded as a primary sacrococcygeal endodermal sinus tumor.

Mucinous Neoplasm of the Appendix (A re-evaluation of 7 Cases of Appendiceal Mucoceles): Jeong Rae Kim, Hae Soo Koo, Moon Hyang Park, Hyo Sook Park; J Pathol Transl Med. 1976;10(2):261-269.

1,059 View
10 Download

Abstract: The designation of mucocele has been traditionally applied to a group of appendiceal lesions characterized by one or more of the following features ; (1) dilatation of the lumen, (2) alterations of the mucosal lining, (3) hypersecretion of mucus, and (4) occasional extension outside the appendix, either as peritoneal implants or exceptionally as distant metastatic spread. The re-evaluation of 7 appenaiceal mucoceles, examined at Department of Pathology, National Medical Center, Seoul, during 17 years from March 1959 to July 1976, was made and showed four distinctive clinicopathologic entities : 1) Secondary mucosal atrophy resulting from proximal luminal obliteration (1 case), accompanied with volvulus. 2) Focal mucosal hyperplasia (1 case), with no epithelial atypia. This case was associated with mucinous adenocarcinoma of cecum. 3) Mucinous cystadenoma (4 cases). Two of these reveal slight degree of cellular atypia and some acellular mucus in peritoneal cavity without adhesion. Remaining two show mucosal ulceration of appendico-cecal junction. 4) Mucinous cystadenocarcinoma (1 case). This case shows focal stromal invasion by atypical glands and/or epithelial cells, also seen in peritoneal implants. On the basis of these findings, most instances of so-called mucocele should be regarded as mucinous neoplasms, analogous in many aspects to the epithelial tumors of the colon, and those diagnostic distinction is justified on practical grounds, since it provides the pathologist and the surgeon with definite criteria on which base prognostic and therapeutic consideration.

A Case of Chromaffin Functional Paraganglioma of the Organs of Zuckerkan이: Jung Bin Lee, Eui Keun Ham, Kook Jin Choi*; J Pathol Transl Med. 1976;10(2):271-275.

1,388 View
10 Download

Abstract: A case of chromaffin functional paraganglioma of the organs of Zuckerkandl is reported in a 17-year-old girl, with severe hypertensive retinopathy (K-W grade Ⅳ) and fluctuating hypertension. Laboratory findings revealed increased VMA in urine and positive regitine test with diabetic oral glucose tolerance curve as well. Simple removal of a mass in an area of organs of Zuckerkandl resulted in complete alleviation of clinical symptoms for 2-year -follow-up period.

Hematological Sturdy on Two Cases of Preleukemia: In Ki Paik, Sang In Kim; J Pathol Transl Med. 1976;10(2):277-283.

1,442 View
10 Download

Abstract: Two cases of preleukemia diagnosed by authors at the Seoul National University Hospital are presented with clinical summary, laboratory results, hematological findings of peripheral blood and bone marrow as well as literature review. The results are summarized as follows. 1) The patients were 27 year old male and 43 year old female. 2) The duration from the onset of initial symptoms to the final diagnosis of acute leukemia was 10 months and 13 months respectively. 3) Initial clinical manifestations were general malaise, bleeding tendency and fever. Hepatomegaly or lymphadenopathy was not the feature of these two cases. 4) Peripheral blood showed pancytopenia in one case and anemia with leukocytosis in another case. Immature erythroid and myeloid cells were observed in peripheral blood smears of both patients with transient monocytosis. Examination of mean corpuscular volume of red blood cell exhibited normocytic to macrocytic and mild anisocytosis with poikilocytosis was their another feature. 5) Bone marrow examination showed hypocellular marrow in one case and normoceilular marrow in another case. Erythroid hyperplasia with megaloblastoid change was observed in both cases. One case exhibited the pattern of maturation arrest in myeloid series. 6) The initial hematological findings of these preleukemia cases were very similar to those of vitamine B12 or folate deficiency, however the treatment with appropriate anti-anemic preparations was ineffective. 7) Most of the preleukemia cases previously reported were diagnosed retrospectively because of the diagnostic difficulties, however authors believe that a keen attention with the understanding of specific hematological features of the preteukemia will discover more cases of this very important disease entity. Hematological features of these preleukemia cases are suggestive of or similar to those of refractory anemia, sideroblastic anemia, aplastic anemia or hypersplenism.

First
Prev
Page of 1
Next
Last

Previous issues