Journal of Pathology and Translational Medicine

Volume 2(1); July 1968

Original Articles

Experimental Studies on the Influence of Cortisone and ACTH upon Antibody Formation in the Rabbit: Sook Hyun Park; J Pathol Transl Med. 1968;2(1):1-12.

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Abstract PDF: An experimental study on the influence of cortisone and ACTH upon the antibody formation in rabbit was performed counting the pyroninophilic cells in the spleen, lymphnode and thymus. The following results and conclusion were obtained. 1. Administration of cortisone and ACTH with immunization produced a decreased number of pyroninophilic cells in the spleen and lymphnodes comparing that of the controls. 2. This suppressive effects of cortisone and ACTH on the pyroninophilic cells were prominent in the rabbits that has been treated with cortisone and ACTH prior to immunization, simulataneous treatment and post-immunization treatment in decreasing order of effects. 3. Cortisone seems to have stronger effects on the pyroninophilic cells in rabbits comparing that of ACTH though it is influenced by the time of immunization. 4. Cortisone and ACTH administration without antigenic stimulation also produced a slighthy increased pyroninophilic cells in the lymphoid tissues. 5. Pyroninophilic cells in the thymus of the mature rabbits are negligible in number and seems not influenced by the treatment of cortisone and ACTH with or without immunization.

A histopathologic study on rectal tumors: Chan kook Rha; J Pathol Transl Med. 1968;2(1):15-22.

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Abstract PDF: A histopathologic study was made on 186 cases of rectal tumors of the Koreans, obtained during a period of 11 years, from 1957 to 1967, at the department of pathology, college of medicine, Seoul National University. 1. The 186 cases of rectal tumors consist of 145 cases of malignant tumors and 41 cases of benign tumors. 2. The malignant and benign tumors occurs more commonly in male than in female, revealing the sex ratio of 2.01: 1 in the malignant and 4.7: 1 in the benign respectively. 3. The age distribution of the rectal tumors varies from 13 to 78 years in malignant tumors and 6 to 71 in benign. The greatest number of rectal carcinomas occurred from 40 to 69 with a peak incidence in 50-59 years, revealing 31.6 per cent of total malignancies of the rectum. 4. The site of distribution of rectal carcinomas are as follows; 71% in the lower one third, 18% in mid one third and 11% in upper one third. In benign tumors, the distributions are similar to that of the malignant, showing the lower one third 50% mid one third 29.1% upper one third 8.33% and entire rectum 12.5%. 5. The gross pattern of the carcinomas are classified into three types, the polypoid type 53.8%, infiltrating 26.2%, and annular 20%. 6. Six cases of polypoid adenoma and a hereditary multiple polyposis were combined with focal malignant changes, which was 17.1% of total benign tumors. 7. The 145 cases of malignant and 41 cases of benign tumors of the rectum were histologically classified and tabulated.

The interaction of radiation marrow damage on the erythroleukemia virus activity: Chung Hee Chi, B. Lagerlof; J Pathol Transl Med. 1968;2(1):25-30.

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Abstract PDF: X-線照射로 生後 1日된 영계(병아리)에 骨髓障碍를 일으켰을 侍赤血球性白血症 virus가 骨髓에 미치는 活性에 대한 相互關係를 實驗的으로 考察하였다. 一群을 C0 60 600r를 照射했으며 4, 8, 20日後에 各各赤血球性白血症 virus를 靜脈內注射하였다. 注射前處置로는 各各大腿骨에서 骨髓의 生檢을 施行하였음. 豫備試驗의 結果全身 X-線照射에 의한 骨髓의 障碍는 고루 미치는 것을 周池하였으므로 전 骨髓의 代表的部位로서 大腿骨을 選定하였다. 對照群으로서 使用한 것은 X-線照射를 하지 않았으며 同一하게 骨髓의 生檢을 4, 8, 20일 후에 施行하고 각각 virus를 接種하였다. 白血症의 發生率과 實驗動物이 死亡하게 될 때까지의 潛伏期間은 照射群과 對照群兩者에서 大同小異하였다. virus 接種의 時期에 關係없이 X-線照射로 인한 骨髓障碍의 程度에 따라 動物群을 分類해 본 結果激甚한 X-線骨髓障碍와 細胞減少症(Hypocellularity)을 主로 하는 動物群은 virus 病原性活性을 抑制함을 提示했으나 한편 中等屠의 障碍를 가진 動物群에서 오히려 virus의 活性度를 加重시켰다. 組織學的으로 赤血球의 再生力에 따라 分類해본 結果活潑한 赤血球造血機能을 가진 動物群은 X-線照射하지 않은 對照群과 同一한 virus의 活性을 나타냈으나 赤血球造血機能의 證據가 없는 動物群에서는 virus에 대한 感受性은 極히 低下돼있었다.

Theory on Arteriosclerosis: Sun Joo Ro, Ph.D.; J Pathol Transl Med. 1968;2(1):33-37.

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Abstract PDF: An evaluation was made on the etiology of arteriosclerosis with cholesterol content of the anterior eye chamber fluid and ocular aortic implant in rabbits. Cholesterol content of the anterior eye chamber fluid ranged from 7 to 31 mg. per cent in spite of an increase of about 30 times in serum. Even highest value, 31mg. per cent is far less than in normal serum. The results indicate that even of atherosclerotic or normal aorta is transplanted to the anterior eye chamber in rabbits to observe the acceleration or development of atherosclerosis it is impossible to relate the incidence of atherosclerosis with cholesterol content of the anterior eye chamber fluid. For this reason atherosclerosis can be produced without hypercholesterolemia and hypertension. Hence the cause of increase of cholesterol content in the ocular aortic implant must be attributed to the etiology of arteriosclerosis. In this case several factors are considered but main cause of increase of cholesterol in ocular aortic implant must be attributed to the imbalance of deposition and consumption of cholesterol in ocular aortic implant. The imbalance of cholesterol deposition and consumption of cholesterol in ocular aortic implant must be attributed to the cholesterol metabolism disturbance of arterial wall itself. As well known, cholesterol plays main role on atherosclerosis as a major factor. Consequently metabolism disturbance definitely contributed to the etiology on arteriosclerosis. Therefore, on the basis of observations noted above it is concluded that etiology on arterisoclerosis is to be found in metabolism disturbance.

Scotochromogens From Tuberculous Patients: Jae Sik Kim, Won Bae Kim, Jae Joo Suh, Yong Ma Hah, Young Myung Kim; J Pathol Transl Med. 1968;2(1):39-43.

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Abstract PDF: The incidence of mycobacterium infection other than tubercle bacilli from tuberculous patients has been reported increasingly in recent years and the significance of unclassified mycobacteria in clinical cases evaluated intensively. In the course of the studies for the distribution of unclassified mycobacteria from tuberclous patients and other sources, authors isolated 29 strains of scotochromogens and tested biochemical characters. 1) Nine strains were isolated from 25 cases of tuberculous patients in mineral industry and 20 strains from various sources of patient from university hospital. 2) All strains isolated were belong to scotochromogens by biochemical characteristics exhibiting following characters; color formation in darkness, strong catalase positive, nitrate reduction negative except one strain and urease positiveness in 24 strains. 3) Growth rate were rather slow grower in Ogawa media forming colonies between 10 and 14 days and sensitivity pattern to antituberculous agents exhibited an usual pattern of unclassified mycobacteria in that test strains were moderately sensitive to streptomycin and isonicotinic acid hydrazide, whereas these were resistant to paraaminosalicylic acid.

Value of Examining Sections of the Bone Marrow Aspirates: Mun Sok Soh; J Pathol Transl Med. 1968;2(1):45-50.

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Abstract PDF: The purpose of this paper is to present some of the advantages of examining sections of bone marrow. For this study the impression received by examining 155 bone marrow smears from 154 patients are compaired with information gathered from sections of this marrow. Forty eight of the sections were of insufficient quantity for proper evaluation. Failure of the aspiration is probably related to both the individual’s technique and the disease. The determination of cellularity made from smears were apparently wrong in 38 out of 110 of these cases. In 9 cases, the misinterpretation was considered extremely serious as hypercellular marrow was misjudged to be hypocellular. This was largely due to small amount of marrow being diluted with peripheral blood. In all cases, if the smear appears to be hypocellular, this should be confirmed by examination. This is especially important when making a diagnosis of aplastic anemia. Also found in the sections were 2 cases of matastatic carcinoma, 2 cases of malignant lymphoma, and 4 cases of mucinous degeneration of the stromal adipose tissue, all of which were impossible to be diagnosed on the smear. In addition, the section is good for evaluation of the number of the megakaryocytes and mitotic figures, and for some extrahematopoietic cells or tissues besides those of malignant origin.

Adrenal Hemorrhage in a Newborn -An Autopsy Case Report-: Kyu Sun Rhee, Je G. Chi; J Pathol Transl Med. 1968;2(1):53-57.

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Abstract PDF: A case of bilateral adrenal hemorrhage in a three-day-old boy who was born after a labor period of more than 19 hours to a pre-eclamptic woman has been presented. The body weight of the baby at autopsy was 4,720 grams. The newborn developed a high fever, convulsion and dyspnea throughout the entire disease course. Autopsy revealed a massive hemorrhage in the adrenal glands especially in the right, replacing the majority of the adrenal tissue proper. There also was a subdural hematoma in the right parietal region. Birth trauma was assumed to be the most important contributing factor of the hemorrhage of the involved case. And it was emphasized that when the signs and symptoms of adrenal insufficiency appear in the infants born with difficulties, the adrenal hemorrhage should be considered first as the underlying cause.

A Case of Embryonal Alveolar Rhabdomyosarcoma Arising From The Nasal Cavity: Sang Kyoon Kang; J Pathol Transl Med. 1968;2(1):59-62.

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Abstract PDF: A 13-years-old girl had been suffered from nasal obstruction due to protruding mass in the right nasal cavity. The mass and cervical lymphnodes were surgically removed. Microscopic findings revealed embryonal alveolar rhabdomyosarcoma with lymphnode metastasis. Characteristic tadpole cell, strap cell and polyheadral giant cells were observed. Also cross striation and myofibril were confirmed by phosphotungustic acid hematoxylin stain.

Carcinoma of Stomach Undiagnosed Antemortem Because of Dominant Presenting Symptoms: Mun Sok Soh, Yeong Man Lee; J Pathol Transl Med. 1968;2(1):65-70.

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Abstract PDF: Dominant presenting symptoms less associated with the primary disease sometimes have led the clinicians to the misdiagnoses. This paper is to report such three examples in which the stomach cancers were found to be primary in the postmortem examinations. Case 1, 29 years old male, was presented with the scapula mass of 6 months duration which was turned out to be metastatic nature. Case 2 was a 25 years old female who was admitted to the hospital with marked ascites and diagnosed as tuberculous peritonitis. This patient had largely serosal dissemination. Case 3 was a 50 years old man who came in with severe amebic colitis which interfered the correct diagnosis. The first two cases of ours, which may be classified as penetrating (or ulcerating) type according to Stout, were without or with insignificant. ulcer formation on the gastric mucosa. Both retreated more exophytic growth of the tumor and presented diagnostic problems. Bony metastasis of stomach cancer observed in Case 1 is reported to be relatively rare.

A case of Sarcoidosis: III Hyang Ko, Ke Hong Kim, Kwang Yul Ko, Byong Sun Chu, Han Yung Lim; J Pathol Transl Med. 1968;2(1):73-82.

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Abstract PDF: A case of sarcoidosis involving skin, cervical Iymph nodes, lacrimal gland & uvea in 46 years old female is presented. Sarcoidosis is not infrequent disease in Scandinavia, England & the United States but known to be rare among the orientals. Diagnosis of the case is confirmed by characteristic non-caseous tubercles in biopsied skin & cervical node, a marked hypergammaglobulinemia with reversed A G ratio, granulomatous uveitis & lacrimal gland involvement as well as general clinical features. The patient was improved dramatically by steroid therapy which is the only effective agent known at present time, to control the activity of the disease process. The presented case is the first proved case of sarcoidosis in Korea.

Original Article

Vascular Tumor of Placenta (Chorioangioma) -A report of the two cases and review of literature-: Duk Yong Kang, Kee Young Bahk, Myoung Duk Rhim, Choon Hye Chun; J Pathol Transl Med. 1968;2(1):83-87.

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Abstract PDF: The grossly detectable chorioangioma is rather rare case in Korea and the case of this variety had not previously reported in Korean literature. The first case is 23-year-old woman (gravida 2, para 0, in 33 weeks gestation), who had premature delivery with oligoamnios and consequent fetal death. The autopsy of the fetus demonstrated no abnormality except slight cardiomegaly. Physical examination of the gravid woman revealed moderate anemia and slight edema just before the delivery. The placenta had 13 of grossly detectable globular tumors up to pigeon’s egg size in fetal surface and inside of huge edematous placenta, weighed 2.4 kg. totally. The second case is 25-year-old gravid woman (gravida 0, in 40 weeks gestation), who had an adult fist sized, single, necrotic tumor mass in the margin of placenta. She delivered a full-term baby with normal post-partum course except slightly increased hemorrhage during delivery and lochia for a month after delivery. The incidence, nomenclature, pathologic findings, nature and origin, associated placental cleanses, maternal factor, clinical side effects during pregnancy, and effects on the fetus and neonate is reviewed and discussed.

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