Journal of Pathology and Translational Medicine

Volume 1(1); October 1967

Original Articles

Experimental Studies on the Influence of Anticancer Agents upon Antibody Formation in Rabbit: Sae Ook Park; J Pathol Transl Med. 1967;1(1):3-14.

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Abstract PDF: Experimental studies were performed to observe the effects of anticancer agents on the immune response in the rabbit. Horse serum immunization and the injection of anticancer agents were continued for 3 weeks with controlled intervals. The pyroninophilic cells in the spleen, mesenteric lymphnodes and thymus were counted for the indication of antibody formation. The following results and conclusion were obtained. 1) Injections of anticancer agents show an increased number of pyroninophilic cells in the spleen and lymphnodes. The degree of this increase is highest in the mitomycin C treated group, and follows 6Mp, 5Fu, methotrexate, nitromin and nitrogen mustard treated groups in decreasing order. 2) Injections of anticancer agents with horse serum immunization show remarkable decrease of the pyroninophilic cells in the spleen and lymphnodes. This effect is most conspicuous in methotrexate and nitrogenmustacd treated group, less conspicuous in nitromin, 6MP and 5Fu treated group, and inconspicuous in mitomycin Ctreated group. 3) It may be concluded that the anticancer agents have inhibitory effects on the experimental antibody formation and the degree of this inhibitory effects is conspicuous in methotrexate, nitrogen mustard, nitromin, 6MP. 5Fu, and Mitomycin C in decreasing order. 4) The pyroninophilic cells in the thymus is neglisible in number in all experimental groups of rabbits.

A Histopathologic Study on Lung Carcinoma: Sang In Kim, Chong Soo Lee, Je G. Chi; J Pathol Transl Med. 1967;1(1):17-22.

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Abstract PDF: A Study was made on 104 cases (autopsy and biopsy) of primary lung carcinoma of Koreans obtained during a period of 10 years, 1957 to 1966, at the Department of Pathology, College of Medicine, Seoul National University. The frequency ratio or relative incidence of lung cancer among all types of malignant tumors in the same period at this Department was 4.7 per cent in male and female together, thus ranking the sixth in frequency in male and the sixteenth in female. The sex ratio of male and female was 5.5:1. The age distribution of lung cancer showed the highest frequency in the decade of 50-59 (34%) and also considerably high frequencies in the decades of 40-49 (27%) and 60-69 (26%). However, when related to the female only, 60-69 group was in the highest frequency. Ages of 104 cases ranged from 26 years to 79 years with the average of 48.2 years of age. The one hundred and four cases of lung carcinoma were classified histologically into five types : squamous cell carcinoma 45 cases (43%), adenocarcinoma 29 cases (28%), oat cell carcinoma 17 cases (16%), undifferentiated carcinoma 12 cases (12%) and mixed type 1 case (0.9%). It was emphasized that several findings of this study are in concord with the results of several other countries that are in definitely increasing tendency of lung cancer.

A Histopathologic Study on Soft Tissue Tumors: Chae Koo Lee, Sang Kook Lee, Je G. Chi; J Pathol Transl Med. 1967;1(1):25-30.

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Abstract PDF: An analysis of 336 cases of malignant and benign tumors of soft tissue, that were examined at the department of pathology, college of medicine, Seoul National University, during a period of 11 years from January 1955 to December 1965 was made. Total 336 soft tissue tumors consisted of 79 malignant and 257 benign tumors, and occupied 10 per cent of total tumors that were examined at this department during the same period. And 79 malignant soft tissue tumors occupied 3.5% of total malignancies during the same period. Seventy-nine malignant and 257 benign soft tissue tumors were histologically classified and tabulated. Among malignant tumors, fibrosarcoma, neurogenic sarcoma, fibroliposarcoma and leiomyosarcoma were especially prevalent, and among benign tumors hemangioma, lipoma, fibroma and neurofibroma were more commonly encountered. Average ages of malignant and benign soft tissue tumors were 37 and 33 years respectively. Male was slightly preponderant than female in both malignant and benign tumors. Site distributions of 336 soft tissue were also tabulated, and some tumors were selected and described in more detail.

A Case of Vesical Sarcoma Botryoides in A Child: Ki Hong Kim, Jeung Ok Park, In Hi Lee; J Pathol Transl Med. 1967;1(1):33-36.

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Abstract PDF: A 15-month-old infant who had a history of dysuria, pyuria, fever and suprapubic tumor mass for a period of days was admitted in June in 1966. The bladder was opened suprapubically. It was filled with grape-like, grey, gelatinous masses. Microscopically the surface epithelium has undergone squamous metaplastic, and neoplastic tissue reveals both myxomatous and fibromatous patterns. In the latter a few tumor giant cells with one or more nuclei are very occasionally seen. In a few areas tumor cells simulate epitheloid arrangement. No mitotic figures. No striation was found on phosphotungustic stain.

Atheromatous Embolism -A Report of 12 Autopsied Cases-: Mun Sok Soh; J Pathol Transl Med. 1967;1(1):37-41.

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Abstract PDF: Embolic phenomenon from atheromatous material of the aorta was first found as early as 1862 by Panum. However, it was not until 1945 that Flory described in detail the pathologic processes of atheromatous embolization in bath human and experimental animals and stressed the importance of its sequelae. Since that time, the cases have been recognized with increasing interest and frequency. Recently, Gore and Collins collected 84 cases and added 16 cases of their own. It Is a purpose of this paper to report 12 additional cases experienced at Georgetown University Hospital, Washington, D.C., U.S.A., and to reemphasize the clinicopathological correlations leading to the following conclusions. Summary and Conclusions 1. Clinicopathological observations on 12 autopsied cases of atheromatous embolism were presented with review of the literatures. 2. Significant clinical implications of the embolism was discussed with particular emphasis on the necessity to differentiate it from true arteritis. 3. All the cases revealed severe ulcerative atherosclerosis of the aorta in common and had as sociated aneurysms in the 8 cases. 4. Many varieties of organs and tissues could be involved and especially the kidney, pancreas and spleen were the three major organs most frequently affected. 5. In none of the cases the atheromatous embolism were immediate cause of death. However, in 4 cases at least it was definitely contributory factor to death.

Pulmonary Hypoplasia Associated with Congenital Diaphragmatic Hernia: Kyu Sun Rhee, Je G. Chi; J Pathol Transl Med. 1967;1(1):43-47.

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Abstract PDF: Two autopsy cases of pulmonary hypoplasia associated with congenital diaphragmatic hernia(Bochdalek foramen) have been presented. The first case is a 12-hour-old new born infant, who was admitted for cyanosis and dyspnea. At operation, the left hemithorax was filled with loops of small intestine which had been herniated through a large defect in the left posterolateral portion of the diaphragm. The defect was properly repaired. However, the patient expired soon after operation showing persistent respiratory difficulty. At autopsy, both lungs were hypoplastic especially in the left, and no evidence of expansion was noted under the microscope. The second case is a 3-day-old newborn infant who was admitted for cyanosis and general weakness. Soon after admission the patient expired. At autopsy, left lung weighed only 5 gm. and consisted of a rather stolid dark gray mass attached to the hilum. The spleen and loops of small intestine were found in the left hemithorax which had been herniated through a round defect in the left posterolateral portion of diaphragm. Pathogenesis of pulmonary hypoplasia associated with diaphragmatic hernia of congenital origin is discussed and the related papers are briefly reviewed.

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