- Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder
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Jiyoon Jung, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
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J Pathol Transl Med. 2018;52(2):121-125. Published online October 5, 2017
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DOI: https://doi.org/10.4132/jptm.2017.08.20
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- Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.
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Citations
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Gastroenterology Research and Practice.2021; 2021: 1. CrossRef - Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature
Amedeo Sciarra, Edoardo Missiaglia, Mounir Trimech, Emmanuel Melloul, Jean-Philippe Brouland, Christine Sempoux, Stefano La Rosa
Endocrine Pathology.2020; 31(1): 84. CrossRef - Mixed neuroendocrine-non-neuroendocrine carcinoma of gallbladder: case report
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World Journal of Surgical Oncology.2019;[Epub] CrossRef
- Hyalinizing Cholecystitis and Associated Carcinoma: A Case Report
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Youngjin Kang, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
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J Pathol Transl Med. 2018;52(1):64-66. Published online April 4, 2017
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DOI: https://doi.org/10.4132/jptm.2016.11.04
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9,818
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Citations
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Clinical Nuclear Medicine.2021; 46(4): e228. CrossRef - Gallbladder Carcinoma and Its Differential Diagnosis at MRI: What Radiologists Should Know
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BMC Cancer.2021;[Epub] CrossRef - KRONİK KOLESİSTİTİN NADİR VE MALİGNİTE POTANSİYELİ YÜKSEK OLAN ALT TİPİ; HYALİNİZE KOLESİSTİT: OLGU SUNUMU
Leymune PARLAK, Bahar MEMİŞ
Balıkesir Medical Journal.2019; 3(3): 129. CrossRef
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