Journal of Pathology and Translational Medicine

Kyung-Han Lee

1 Article

Molecular Imaging in the Era of Personalized Medicine: Kyung-Ho Jung, Kyung-Han Lee; J Pathol Transl Med. 2015;49(1):5-12. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.10.24

13,023 View
202 Download
30 Web of Science
26 Crossref

Clinical imaging creates visual representations of the body interior for disease assessment. The role of clinical imaging significantly overlaps with that of pathology, and diagnostic workflows largely depend on both fields. The field of clinical imaging is presently undergoing a radical change through the emergence of a new field called molecular imaging. This new technology, which lies at the intersection between imaging and molecular biology, enables noninvasive visualization of biochemical processes at the molecular level within living bodies. Molecular imaging differs from traditional anatomical imaging in that biomarkers known as imaging probes are used to visualize target molecules-of-interest. This ability opens up exciting new possibilities for applications in oncologic, neurological and cardiovascular diseases. Molecular imaging is expected to make major contributions to personalized medicine by allowing earlier diagnosis and predicting treatment response. The technique is also making a huge impact on pharmaceutical development by optimizing preclinical and clinical tests for new drug candidates. This review will describe the basic principles of molecular imaging and will briefly touch on three examples (from an immense list of new techniques) that may contribute to personalized medicine: receptor imaging, angiogenesis imaging, and apoptosis imaging.

Citations

Citations to this article as recorded by

Ionic Cell Microscopy: A new modality for visualizing cells using microfluidic impedance cytometry and generative artificial intelligence
Mahtab Kokabi, Gulam M. Rather, Mehdi Javanmard
Biosensors and Bioelectronics: X.2025; 24: 100619. CrossRef
Supramolecular fluorescence biosensing based on macrocycles
Jia-Hong Tian, Haiqi Xu, Xin-Yue Hu, Dong-Sheng Guo
Supramolecular Materials.2024; 3: 100063. CrossRef
A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis
Xueli Zhao, Yuze Qin, Bo Wang, Jiao Liu, Yueyue Wang, Kun Chen, Jia Zhao, Lanlan Zhang, Yuanming Wu, Liwen Liu
Nanoscale Advances.2024; 6(14): 3590. CrossRef
The Role of Molecular Imaging in Personalized Medicine
Suliman Salih, Aisyah Elliyanti, Ajnas Alkatheeri, Fatima AlYafei, Bashayer Almarri, Hasina Khan
Journal of Personalized Medicine.2023; 13(2): 369. CrossRef
Development of a multifunctional platform for near-infrared imaging and targeted radionuclide therapy for tumors
Huihui He, Ke Li, Hang Li, Shiliang Zhu, Shuai Qin, Yong Mao, Jianguo Lin, Ling Qiu, Chunjing Yu
European Journal of Pharmaceutics and Biopharmaceutics.2023; 185: 107. CrossRef
Quantum Biotechnology
Nicolas P. Mauranyapin, Alex Terrasson, Warwick P. Bowen
Advanced Quantum Technologies.2022;[Epub] CrossRef
Preparation Fe3O4@chitosan-graphene quantum dots nanocomposites for fluorescence and magnetic resonance imaging
Kai Wang, Xiaoguang Xu, Yan Li, Mayifei Rong, Lifeng Wang, Liying Lu, Jian Wang, Fengwen Zhao, Bowen Sun, Yong Jiang
Chemical Physics Letters.2021; 783: 139060. CrossRef
Network Medicine: A Clinical Approach for Precision Medicine and Personalized Therapy in Coronary Heart Disease
Teresa Infante, Luca Del Viscovo, Maria Luisa De Rimini, Sergio Padula, Pio Caso, Claudio Napoli
Journal of Atherosclerosis and Thrombosis.2020; 27(4): 279. CrossRef
Nanodrug Delivery Systems for the Treatment of Ovarian Cancer
Jonathan M. Pantshwa, Pierre P. D. Kondiah, Yahya E. Choonara, Thashree Marimuthu, Viness Pillay
Cancers.2020; 12(1): 213. CrossRef
Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer
V. M. Baart, R. D. Houvast, L. F. de Geus-Oei, P. H. A. Quax, P. J. K. Kuppen, A. L. Vahrmeijer, C. F. M. Sier
EJNMMI Research.2020;[Epub] CrossRef
In vivo SPECT imaging of an 131I-labeled PM 2.5 mimic substitute
Dong-Hui Pan, Jie Sheng, Xin-Yu Wang, Qian-Huan Huang, Jun-Jie Yan, Li-Zhen Wang, Run-Ling Yang, Dong-Jian Shi, Yu-Ping Xu, Ming-Qing Chen
Nuclear Science and Techniques.2020;[Epub] CrossRef
Optofluidics in bio-imaging applications
Sihui Chen, Rui Hao, Yi Zhang, Hui Yang
Photonics Research.2019; 7(5): 532. CrossRef
Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications
Alberto Boretti, Lorenzo Rosa, Jonathan Blackledge, Stefania Castelletto
Beilstein Journal of Nanotechnology.2019; 10: 2128. CrossRef
Online molecular image repository and analysis system: A multicenter collaborative open-source infrastructure for molecular imaging research and application
Mahabubur Rahman, Hiroshi Watabe
Computers in Biology and Medicine.2018; 96: 233. CrossRef
Nε-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure–Activity Relationships, and Pharmacokinetic Profiling
Robert Wodtke, Christoph Hauser, Gloria Ruiz-Gómez, Elisabeth Jäckel, David Bauer, Martin Lohse, Alan Wong, Johanna Pufe, Friedrich-Alexander Ludwig, Steffen Fischer, Sandra Hauser, Dieter Greif, M. Teresa Pisabarro, Jens Pietzsch, Markus Pietsch, Reik Lö
Journal of Medicinal Chemistry.2018; 61(10): 4528. CrossRef
Genomic Interventions in Medicine
Oluwadurotimi S Aworunse, Oluwatomiwa Adeniji, Olusola L Oyesola, Itunuoluwa Isewon, Jelili Oyelade, Olawole O Obembe
Bioinformatics and Biology Insights.2018;[Epub] CrossRef
Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI
Ryan L. Brunsing, Natalie M. Schenker-Ahmed, Nathan S. White, J. Kellogg Parsons, Christopher Kane, Joshua Kuperman, Hauke Bartsch, Andrew Karim Kader, Rebecca Rakow-Penner, Tyler M. Seibert, Daniel Margolis, Steven S. Raman, Carrie R. McDonald, Nikdokht
Journal of Magnetic Resonance Imaging.2017; 45(2): 323. CrossRef
Personalized medicine: a new option for nuclear medicine and molecular imaging in the third millennium
Orazio Schillaci, Nicoletta Urbano
European Journal of Nuclear Medicine and Molecular Imaging.2017; 44(4): 563. CrossRef
Nano-Magnetic Resonance Imaging (Nano-MRI) Gives Personalized Medicine a New Perspective
Lorenzo Rosa, Jonathan Blackledge, Albert Boretti
Biomedicines.2017; 5(1): 7. CrossRef
Optical nanoprobes for biomedical applications: shining a light on upconverting and near-infrared emitting nanoparticles for imaging, thermal sensing, and photodynamic therapy
E. Hemmer, P. Acosta-Mora, J. Méndez-Ramos, S. Fischer
Journal of Materials Chemistry B.2017; 5(23): 4365. CrossRef
Drug Discovery by Molecular Imaging and Monitoring Therapy Response in Lymphoma
Senthilkumar Kalimuthu, Ju Hye Jeong, Ji Min Oh, Byeong-Cheol Ahn
International Journal of Molecular Sciences.2017; 18(8): 1639. CrossRef
Chemistry and engineering of cyclodextrins for molecular imaging
Wing-Fu Lai, Andrey L. Rogach, Wing-Tak Wong
Chemical Society Reviews.2017; 46(20): 6379. CrossRef
Prototypes of Lanthanide(III) Agents Responsive to Enzymatic Activities in Three Complementary Imaging Modalities: Visible/Near-Infrared Luminescence, PARACEST-, and T1-MRI
Jiefang He, Célia S. Bonnet, Svetlana V. Eliseeva, Sara Lacerda, Thomas Chauvin, Pascal Retailleau, Frederic Szeremeta, Bernard Badet, Stéphane Petoud, Éva Tóth, Philippe Durand
Journal of the American Chemical Society.2016; 138(9): 2913. CrossRef
Nanoparticles in practice for molecular-imaging applications: An overview
Parasuraman Padmanabhan, Ajay Kumar, Sundramurthy Kumar, Ravi Kumar Chaudhary, Balázs Gulyás
Acta Biomaterialia.2016; 41: 1. CrossRef
A new neuroinformatics approach to personalized medicine in neurology: The Virtual Brain
Maria I. Falcon, Viktor Jirsa, Ana Solodkin
Current Opinion in Neurology.2016; 29(4): 429. CrossRef
Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance
Joonseok Lee, Andrew C. Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C. Larson, Elena A. Rozhkova, Dong-Hyun Kim
Biomaterials.2016; 109: 69. CrossRef

Author index