- Pediatric granular cell tumor in the posterior wall of the larynx extending to the trachea
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Jungsuk Ahn, Na Rae Kim, Yong Han Sun
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J Pathol Transl Med. 2020;54(4):336-339. Published online April 15, 2020
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DOI: https://doi.org/10.4132/jptm.2020.02.28
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- Granular cell tumor (GCT) is a slow-growing benign neoplasm that can be found in any organ. Pediatric laryngotracheal GCT is rare. We experienced a 6-year-old boy suffering from a barking cough and symptoms of stridor and croup for one month. Head and neck computed tomography revealed a protruding mass that occluded 60% of the airway lumen. Under the impression of hemangioma or papilloma, excision revealed a submucosal non-encapsulated mass. Histologically, the mass was composed of sheets of large polyhedralshaped tumor cells containing plump eosinophilic granular cytoplasm and centrally placed, small, bland-appearing nuclei. The tumor cells were positive for S-100 protein, and voluminous eosinophilic cytoplasm was stained by diastase-resistant periodic acid-Schiff. The present report describes a unique case of a huge pediatric laryngeal GCT extending to the subglottic trachea. We also review the clinical course of pediatric laryngotracheal GCT and emphasize the importance of diagnosing GCT in children.
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Citations
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- Pediatric granular cell tumor of the larynx: A case report and literature review
Jing Ke, Junwei Xiong, Juhong Zhang, Haiyu Ma, Wei Yuan Journal of Cancer Research and Therapeutics.2023; 19(4): 1070. CrossRef
- A Case of Primary Subpleural Pulmonary Microcystic Myxoma Coincidentally Occurred with Pulmonary Adenocarcinoma
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Jungsuk Ahn, Na Rae Kim, Seung Yeon Ha, Keun-Woo Kim, Kook Yang Park, Yon Mi Sung
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J Pathol Transl Med. 2015;49(3):274-278. Published online May 15, 2015
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DOI: https://doi.org/10.4132/jptm.2015.03.12
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- Endobronchial Myxoma
Arindam Mukherjee, Ritesh Agarwal, Sahajal Dhooria, Pawan Singh, Amanjit Bal, Harkant Singh, Inderpaul S. Sehgal Journal of Bronchology & Interventional Pulmonology.2018; 25(4): 335. CrossRef
- Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
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Seung Yeon Ha, Jungsuk Ahn, Mee Sook Roh, Joungho Han, Jae Jun Lee, Boin Lee, Jun Yim
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Korean J Pathol. 2013;47(3):252-257. Published online June 25, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.252
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- Background
The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. MethodsWe analyzed the cytopathological
findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. ResultsCytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. ConclusionsThe characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).
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