Myeloid sarcoma is a rare extramedullary myeloid tumor, which is frequently misdiagnosed when no evidence of leukemia is initially observed. Here, we report on a peculiar case of a 49-year-old man afflicted with multiple masses in the jejunum, the superior mesentery, and the serosa of the transverse colon, without leukemic manifestation. The tumor was composed of undifferentiated small round cells containing eosinophilic cytoplasm, which were negative for myeloperoxidase, nonspecific esterase, lysozyme, terminal deoxynucleotidyl transferase, leukocyte common antigen, CD3, CD4, CD15, CD20, CD30, CD43, CD56, CD68/PG-M1, CD79a, human melanoma black-45, c-kit, and CD34 with positivity only for CD68/KP1, CD99, and vimentin. Under electron microscopy, those cells had abundant membrane-bound cytoplasmic granules that measured 200 to 300 nm in diameter, which were consistent with granulocytic azurophilic granules. The tumor was finally diagnosed as a myeloid sarcoma. The presence of non-leukemic myeloid sarcomas showing immunonegativity for conventional myeloid-leukemic markers necessitated a diagnosis by ultrastructural observation.

Citations

Citations to this article as recorded by  

• Primary ileal myeloid sarcoma presenting with bowel obstruction: a case report
  Hitoshi Minagi, Nobuhiko Kanaya, Yoshitaka Kondo, Yoshihiko Kakiuchi, Shinji Kuroda, Ryohei Shoji, Hajime Kashima, Yuki Matsumi, Satoru Kikuchi, Kunitoshi Shigeyasu, Fuminori Teraishi, Shunsuke Kagawa, Toshiyoshi Fujiwara
  Surgical Case Reports.2024;[Epub]     CrossRef
• Isolated myeloid sarcoma presenting with small bowel obstruction: a case report
  Rie Mizumoto, Masanori Tsujie, Tomoko Wakasa, Kotaro Kitani, Hironobu Manabe, Shuichi Fukuda, Kaoru Okada, Shumpei Satoi, Hajime Ishikawa, Toshihiko Kawasaki, Hitoshi Hanamoto, Masao Yukawa, Masatoshi Inoue
  Surgical Case Reports.2020;[Epub]     CrossRef
• Primary Myeloid Sarcoma of the Ileum and Mesentery Causing Small Bowel Obstruction: Case Report and Literature Review
  Andrej Nikolovski, Dragoslav Mladenovikj, Aleksandra Veljanovska, Gordana Petrusevka
  Lietuvos chirurgija.2020; 19(1-2): 55.     CrossRef
• Utility of Transmission Electron Microscopy in Small Round Cell Tumors
  Na Rae Kim, Seung Yeon Ha, Hyun Yee Cho
  Journal of Pathology and Translational Medicine.2015; 49(2): 93.     CrossRef