- A sinonasal yolk sac tumor in an adult
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Jaehoon Shin, Ji Heui Kim, Kyeong Cheon Jung, Kyung-Ja Cho
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J Pathol Transl Med. 2022;56(3):152-156. Published online January 26, 2022
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DOI: https://doi.org/10.4132/jptm.2021.12.09
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 Abstract
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- Yolk sac tumors (YSTs), which are also called endodermal sinus tumors, are malignant tumors of germ cell origin. These tumors usually occur in the gonads, but 20% of cases have been reported at extragonadal sites. The head and neck is a rarely affected region that accounts for just 1% of all malignant tumors of germ cell origin. In addition, YSTs arise mostly in childhood. We present a rare pathologically pure case of primary adult YST in the sinonasal area. A 45-year-old male patient presented with a rapidly growing mass in the nasal cavity, which caused nasal obstruction and bloody post-nasal drip. The histopathologic features indicated pure YST, and immunohistochemical analysis revealed positive reactivity for Sal-like protein 4 and alpha-fetoprotein. Herein, we discuss the clinical, radiologic, and histologic features of this YST and review other cases of sinonasal YST in adults.
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Citations
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American Journal of Surgical Pathology.2025; 49(4): 381. CrossRef - International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors
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JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY.2023; 33(1): 41. CrossRef - A Novel Successful Case of Nasal and Sinus Yolk Sac Tumor With SMARCB1 (INI-1) Deficiency: A Case Report
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