Journal of Pathology and Translational Medicine

Chung Su Hwang

5 Articles

Comparison of tissue-based and plasma-based testing for EGFR mutation in non–small cell lung cancer patients: Yoon Kyung Kang, Dong Hoon Shin, Joon Young Park, Chung Su Hwang, Hyun Jung Lee, Jung Hee Lee, Jee Yeon Kim, JooYoung Na; J Pathol Transl Med. 2025;59(1):60-67. Published online January 15, 2025; DOI: https://doi.org/10.4132/jptm.2024.10.01

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Abstract PDF: Background
Epidermal growth factor receptor (EGFR) gene mutation testing is crucial for the administration of tyrosine kinase inhibitors to treat non–small cell lung cancer. In addition to traditional tissue-based tests, liquid biopsies using plasma are increasingly utilized, particularly for detecting T790M mutations. This study compared tissue- and plasma-based EGFR testing methods.
Methods
A total of 248 patients were tested for EGFR mutations using tissue and plasma samples from 2018 to 2023 at Pusan National University Yangsan Hospital. Tissue tests were performed using PANAmutyper, and plasma tests were performed using the Cobas EGFR Mutation Test v2.
Results
All 248 patients underwent tissue-based EGFR testing, and 245 (98.8%) showed positive results. Of the 408 plasma tests, 237 (58.1%) were positive. For the T790M mutation, tissue biopsies were performed 87 times in 69 patients, and 30 positive cases (38.6%) were detected. Plasma testing for the T790M mutation was conducted 333 times in 207 patients, yielding 62 positive results (18.6%). Of these, 57 (27.5%) were confirmed to have the mutation via plasma testing. Combined tissue and plasma tests for the T790M mutation were positive in nine patients (13.4%), while 17 (25.4%) were positive in tissue only and 12 (17.9%) in plasma only. This mutation was not detected in 28 patients (43.3%).
Conclusions
Although the tissue- and plasma-based tests showed a sensitivity of 37.3% and 32.8%, respectively, combined testing increased the detection rate to 56.7%. Thus, neither test demonstrated superiority, rather, they were complementary.

Primary testicular carcinoid tumor with marked lymphovascular invasion: Hyun Jung Lee, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Dong Hoon Shin, Jee Yeon Kim; J Pathol Transl Med. 2021;55(6):410-414. Published online October 20, 2021; DOI: https://doi.org/10.4132/jptm.2021.09.11

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Testicular carcinoid tumors are very rare, accounting for less than 1% of all testicular tumors. We report a rare case of a testicular carcinoid tumor with extensive lymphatic invasion. A 42-year-old man presented with a painless, enlarged right testicular mass. There was no history of injury or discomfort in this region. Right radical orchiectomy was performed, which showed a well-defined, non-encapsulated solid white mass with calcification (7.0 × 4.5 × 3.5 cm) and absence of cystic components. Microscopic examination using hematoxylin and eosin staining of the tumor sections identified organoid, trabecular, and solid patterns with rosette formation. Extensive multifocal lymphatic invasion was observed. Immunohistochemistry was positive for synaptophysin, chromogranin, and CD56. Testicular carcinoid tumors usually show good prognoses; however, there was extensive lymphovascular invasion in this case. Thus, in the case of unusual presentation of the disease, close follow-up is necessary.

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Testicular Primary Well-Differentiated Neuroendocrine Tumor: Clinicopathologic, Immunohistochemical, and Molecular Characterization of Two Patients
Liwei Jia, Bo Zhang, Daniel Shen, Prasad R. Koduru
International Journal of Surgical Pathology.2024; 32(8): 1574. CrossRef

Gastric Langerhans Cell Histiocytosis: Case Report and Review of the Literature: So Jung Lee, Chung Su Hwang, Gi Young Huh, Chang Hun Lee, Do Youn Park; J Pathol Transl Med. 2015;49(5):421-423. Published online June 9, 2015; DOI: https://doi.org/10.4132/jptm.2015.05.19

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Isolated Adult Gastrointestinal Tract Langerhans Cell Histiocytosis—Report of Two Rare Patients with Review of Literature
Ekta Jain, Eric Ollila, Fatme Ghandour, Abrar Alghamdi, Samuel Borak, Sameer Al Diffalha
International Journal of Surgical Pathology.2025;[Epub] CrossRef
Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
Jianmin Zhao, Yanlei Li, Yanlin Zhang, Xue Mei, Wei Liu, Yinghong Li
Journal of Hematopathology.2024; 17(2): 63. CrossRef
Clinical Characteristics and Outcomes in Patients With Localized Gastric Langerhans Cell Histiocytosis: A Case Series
Tae-Se Kim, Soomin Ahn, Yang Won Min, Hyuk Lee, Jun Haeng Lee, Poong-Lyul Rhee, Jae J. Kim, Byung-Hoon Min
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2024; 24(2): 175. CrossRef
Isolated Langerhans cell histiocytosis of the stomach in adults: An analysis of clinicopathologic characteristics and molecular genetics
Ruinuan Wu, Yali Zhao, Xikang Wu, Huihui Gui, Xia Liu, Zhaohui Liu
Medicine.2024; 103(51): e40950. CrossRef
Unifocal Gastric Langerhans Cell Histiocytosis in a Child—A Unique Case to Remember
Bhaswati C. Acharyya, Mandira Roy, Hema Chakraborty
JPGN Reports.2022; 3(2): e192. CrossRef
Langerhans Cell Histiocytosis with the Synchronous Invasion of Stomach and Colon in an Adult Patient: A Case Report
Seong Je Kim, Se In Hah, Ji Yoon Kwak, Jung Woo Choi, Hyun Chin Cho, Chang Yoon Ha, Woon Tae Jung, Ok Jae Lee, Chang Min Lee
The Korean Journal of Gastroenterology.2022; 80(3): 149. CrossRef
Gastrointestinal Langerhans cell histiocytosis with unifocal, single‐system involvement in adults: Cases report and literature review
Li Wang, Fang Yang, Yong Ding, Lixia Lu, Haili Li, Yangyang Cui, Lu Lu, Xiaohan Shen, Rong Ge
Journal of Clinical Laboratory Analysis.2022;[Epub] CrossRef
Upper Gastrointestinal Langerhans Cell Histiocytosis: A Report of 2 Adult Cases and a Literature Review
Yui Matsuoka, Yoshiki Iemura, Masakazu Fujimoto, Shinsuke Shibuya, Atsushi Yamada, Shigehiko Fujii, Toshihiro Kusaka, Takero Shindo, Sachiko Minamiguchi, Hironori Haga
International Journal of Surgical Pathology.2021; 29(5): 550. CrossRef
Langerhans cell histiocytosis of the gastrointestinal tract
Aoife J. McCarthy, Madiha Emran Soofi, Imaad Mujeeb, Runjan Chetty
Diagnostic Histopathology.2018; 24(4): 154. CrossRef

A Ciliated Cyst with Müllerian Differentiation Arising in the Posterior Mediastinum: So Jung Lee, Chung Su Hwang, Do Youn Park, Gi Young Huh, Chang Hun Lee; Korean J Pathol. 2014;48(5):401-404. Published online October 27, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.401

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Cyst of Hattori: A Rare Cyst in the Posterior Mediastinum
Matthew D. Turner, Elicia Goodale, Barry C. Gibney, Maria Cecilia D. Reyes
International Journal of Surgical Pathology.2023; 31(4): 431. CrossRef
A large retroperitoneal Mullerian cyst: case report and review of the literature
Elena Parmentier, Jody Valk, Paul Willemsen, Caroline Mattelaer
Acta Chirurgica Belgica.2021; 121(4): 278. CrossRef
A case of resected Mullerian cyst in posterior mediastinum
Yoshiyuki Susaki, Noriyoshi Sawabata
The Journal of the Japanese Association for Chest Surgery.2020; 34(2): 137. CrossRef
Serosal Inclusion Cysts and Arteriovenous Fistulas in Paraprostatic Area of a Dog
Daisuke KOJIMA, Kyoko KOJIMA, Kazumi OTA, Yoshihiko KOJIMA
Journal of the Japan Veterinary Medical Association.2020; 73(9): 511. CrossRef
A surgical case of Mullerian cyst in the posterior mediastinum
Yusuke Kita, Yoshimasa Tokunaga, Taku Okamoto
The Journal of the Japanese Association for Chest Surgery.2019; 33(1): 68. CrossRef
CT and MRI characteristics for differentiating mediastinal Müllerian cysts from bronchogenic cysts
M. Kawaguchi, H. Kato, A. Hara, N. Suzui, H. Tomita, T. Miyazaki, H. Iwata, M. Matsuo
Clinical Radiology.2019; 74(12): 976.e19. CrossRef
A case of Mullerian cyst arising in the posterior mediastinum
Masahiro Adachi, Isao Sano, Shintaro Hashimoto, Ryoichiro Doi, Hideki Taniguchi, Kazuto Shigematsu
The Journal of the Japanese Association for Chest Surgery.2018; 32(6): 713. CrossRef
Two resected cases of Mullerian cyst in the posterior mediastinum
Shotaro Hashimoto, Masato Hisano, Masato Morimoto
The Journal of the Japanese Association for Chest Surgery.2018; 32(7): 818. CrossRef
Posterior mediastinal Müllerian cyst: a rare cause of pain in a young woman
Rebecca Weedle, Keith Conway, Igor Saftic, Alan Soo
Asian Cardiovascular and Thoracic Annals.2017; 25(6): 466. CrossRef

Nodular Fasciitis of the Parotid Gland, Masquerading as Pleomorphic Adenoma: Chung Su Hwang, Chang Hun Lee, Ahrong Kim, Nari Shin, Won Young Park, Min Gyoung Park, Do Youn Park; Korean J Pathol. 2014;48(5):366-370. Published online October 27, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.366

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Abstract PDF

It is difficult to distinguish nodular fasciitis (NF) from other neoplasm of the parotid gland, especially pleomorphic adenoma (PA) by fine needle aspiration cytology. A 39-year-old female noticed a mass in the parotid region. The aspirate material showed cohesive parts composed of the cells that had oval or spindle-shaped nuclei and relatively abundant cytoplasm and some cells with plasmacytoid features. The background substance was fibromyxoid. PA was diagnosed based on the cytologic findings. Subsequently, parotidectomy was performed and NF was diagnosed based on histologic and immunohistochemical findings. NF in the parotid region is rare and may be misdiagnosed as other benign or malignant tumors of the parotid gland. The clinical history of rapid growth and the presence of mitoses and inflammatory cells help to distinguish NF from PA. In addition, immunohistochemical stains for smooth muscle actin and CD68 are useful to confirm the diagnosis of NF.

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A case report of nodular fasciitis of the parotid gland: An entity of concern
Andrea Varazzani, Laura Tognin, Silvia Eleonora Gazzani, Luigi Corcione, Tito Poli
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2024; 36(3): 422. CrossRef
Cytologic findings of nodular fasciitis in the parotid region
Yoshihiro KATO, Keiko TSUCHIDO, Makoto YAMADA, Yasuhiro AKAZAWA, Shogo MIZUNO, Yoshiro OTSUKI, Shin-ichi SHIMIZU, Hiroshi KOBAYASHI
The Journal of the Japanese Society of Clinical Cytology.2024; 63(3): 129. CrossRef
A Case of Parotid Nodular Fasciitis in Children and Literature Review
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Advances in Clinical Medicine.2024; 14(10): 854. CrossRef
A Rare Case of Parotid Nodular Fasciitis in a Six-Month-Old Female
Mazin Merdad, Linah Qasim, Mohammed Nujoom, Hani Z Marzouki, Abdulaziz Neazy
Cureus.2023;[Epub] CrossRef
A rare case of nodular fasciitis presenting as a parotid tumor: Clues to cytodiagnosis
Seetu Palo, Chitrawati Bal Gargade
Journal of Laboratory Physicians.2023; 16: 124. CrossRef
Condylar Reshape in Orthognathic Surgery: Morphovolumetric and Densitometric Analysis Based on 3D Imaging and Digital Workflow
Vincenzo Abbate, Giovanni Audino, Giovanni Dell’Aversana Orabona, Marco Friscia, Paola Bonavolontà, Carmelo Lo Faro, Umberto Committeri, Carlos Navarro Cuéllar, Giorgio Iaconetta, Luigi Califano
Journal of Maxillofacial and Oral Surgery.2022; 21(2): 501. CrossRef
Nodular fasciitis of the submandibular gland
Ting Suen Wong, Richard Wei Chern Gan, Laszlo Karsai, Bun Yin Winson Wong
BMJ Case Reports.2022; 15(4): e245584. CrossRef
Nodular fasciitis in cervicofacial region: a rare case description and literature review
Vincenzo Abbate, Giovanni Dell’Aversana Orabona, Giovanni Audino, Antonio Romano, Paola Bonavolontà, Daniela Russo, Silvia Varricchio, Roberto Ferrigno, Giorgio Iaconetta, Luigi Califano
Oral Surgery.2022; 15(4): 550. CrossRef
Nodular fasciitis of the parotid gland engulfing the facial nerve: a conservative approach
Stephen Bennett, Kristian Hutson, Olakunle Ajayi, Andreas Hilger
BMJ Case Reports.2019; 12(10): e231203. CrossRef

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