- Oncocytoma and Oncocytic Carcinoma of the Salivary Glands, Single Institute Experience.
-
Jeong Hyeon Jo, Seung Ho Choi, Jong Lyel Roh, Soon Yuhl Nam, Sang Yoon Kim, Kyung Ja Cho
-
Korean J Pathol. 2010;44(4):370-375.
-
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.370
-
-
3,825
View
-
58
Download
-
1
Crossref
-
 Abstract
 PDF
- BACKGROUND
Oncocytic neoplasms of the salivary glands are rare and the differential diagnosis between oncocytic carcinomas (OCs) and oncocytomas is difficult. We present 5 cases of oncocytoma and 3 cases of OC of the salivary glands with clinicopathological and immunohistochemical comparisons.
METHODS
Eight cases of oncocytic neoplasms diagnosed at Asan Medical Center between 1998 and 2009 were reviewed for clinical data and histological features. Immunohistochemical staining for epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (Her-2), c-kit, p53, and Ki-67 was done.
RESULTS
Cytological differences between oncocytomas and OCs were not obvious, but unequivocal infiltrative growths were identified in 3 cases, rendering the diagnosis of oncocytic carcinoma. When the remaining cases were classified as oncocytomas, there was no difference in age, size, and clinical symptoms between oncocytomas and OCs. Two of 3 OCs showed strong membranous expression of c-kit, but all oncocytomas were negative. The proportion of p53-positive cells was larger in OCs than oncocytomas. Her-2 or EGFR expression was absent, and Ki-67 labeling indices were less than 1% in all cases.
CONCLUSIONS
An infiltrative growth pattern, strong membranous expression of c-kit, and an increased proportion of p53-positive cells are features that can differentiate OCs from oncocytomas of the salivary glands.
-
Citations
Citations to this article as recorded by  - Primary oncocytic carcinoma of ectopic salivary gland: a unique case
E. Touli, A. Manganaris, C. Nikolaidou, I. Karasmanis
International Journal of Oral and Maxillofacial Surgery.2022; 51(4): 463. CrossRef
- Granular Cell Tumors of the Larynx: Report of Three Cases.
-
Ilseon Hwang, Jeong Eun Hwang, Seung Ho Choi, Soon Yuhl Nam, Kyung Ja Cho
-
Korean J Pathol. 2007;41(4):284-287.
-
-
-
Abstract
PDF
- Granular cell tumors are rare and usually benign neoplasms that can occur in various parts of the body. We recently encountered three cases of granular cell tumor of the larynx; here, we present their clinicopathologic features, along with a review of reported Korean cases.
- Primary Mucosal Desmoplastic Melanoma of Gingiva: A Case Report.
-
Gawon Choi, Jeong Won Kim, Soon Yuhl Nam, Kyung Ja Cho
-
Korean J Pathol. 2006;40(6):456-460.
-
-
-
Abstract
PDF
- Desmoplastic melanoma (DM) is a rare malignant melanoma variant. Although DM mainly affects the skin chronically exposed to the sun, a small number of mucosal DM have been reported. Primary mucosal DM is difficult to diagnose because of its rarity and atypical histopathologic features.
Here, we report a case of DM in a 52 year-old female who presented with a right cervical mass and upper gingival pigmentation. A CT scan revealed an ill-defined infiltrative mass 2 cm in size under the pigmented mucosa. She subsequently underwent a partial maxillectomy with neck dissection. Gross examination revealed that the mass exhibited a grayish white fibrotic cut surface and that the maxillary bone had been destroyed. Microscopically, the main mass was composed of cigar-shaped or wavy spindle cells with desmoplastic stroma under the melanoma in situ. The diagnosis of DM was confirmed immunohistochemically with S100 protein positivity and HMB45 negativity. The patient has survived for 29 months after the operation with a presumed metastatic focus.
|
E-submission
