Journal of Pathology and Translational Medicine

Kyung Rak Sohn

3 Articles

Spindle Cell/Pleomorphic Lipoma of the Oropharynx.: Mi Jin Gu, Kyung Rak Sohn, Jun Ho Park; Korean J Pathol. 2009;43(6):580-582.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.580

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We report a rare case of spindle cell/pleomorphic lipoma of the oropharynx. A 45-year-old woman presented with a 9-month history of a lump in 2001. A well demarcated polypoid, rubbery mass was found in the left vallecula and was surgically removed. The mass was diagnosed as a spindle cell lipoma. She revisited with the same complaint in 2008. Examination revealed another polypoid mass at the left aryepiglottic fold, near the previous excision site. The excised mass histologically consisted of mature fat cells, numerous bizarre giant cells, and bland spindle cells, features of a typical pleomorphic lipoma. This is the first case of recurrent oropharyngeal spindle cell/pleomorphic lipoma, showing histologic changes during the recurrence. Complete removal and follow-up are necessary for the treatment of this uncommon neoplasm.

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A Case of Spindle Cell Lipoma on Nasal Dorsum of Nose
Ki Jin Kwon, Tae Hoon Kim, Sun Kyu Lee, Kun Hee Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2021; 64(1): 26. CrossRef
Un lipome rétropharyngé de présentation clinique inhabituelle
Anne Guyot, Jean-Marc Prechoux, Sylvain Cherrière, Jean-Pierre Bessede, Isabelle Pommepuy, Bema Coulibaly
Annales de Pathologie.2015; 35(4): 372. CrossRef
Retropharyngeal Spindle Cell/Pleomorphic Lipoma
Hyun Kyung Lee, Seung Bae Hwang, Gyung Ho Chung, Ki Hwan Hong, Kyu Yun Jang
Korean Journal of Radiology.2013; 14(3): 493. CrossRef

A Study on the Pathogenesis of Renal Papillary Necrosis Induced by Endotoxin.: Kyung Rak Sohn, Tae Joong Sohn; Korean J Pathol. 1989;23(4):416-454.

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Abstract PDF: The author carried out an experimentation to clarify a possible pathogenesis of renal papillary necrosis induced by an univisceral Shwartzman reaction. The experimental animals were healthy white rabbits in weighing between 1.7 kg and 3.0 kg. Under the condition of ureterostomy, animals were pretreated with 0.5 cc of 50% ethyl alcohol and followed by administration of 0.2 ~ 1.5 mg endotoxin (E. coli 026 : B6, bacto lipopolysaccharide B. Difco, U.S.A.) as preparation in the renal pelvis. And then sacrificed at 10 minutes, 30 minutes, 1 hour, 2 hours, 6 hours and 24 hours after intravenous injection of 0.2 mg or 0.6 mg endotoxin through the ear veins, subjection to examine light and electron microscopically. The obtained results were summarized as follows: Papillary necrosis was developed in 88% among 18 cases excluding 6 cases died before sacrification. There were two types of necrosis, namely papillary and medullary type, but the former and combined forms of both types were the most common findings. Initial main target site of injury in renal papilla induced by endotoxiin was the endothelium of vasa recta and then followed by the Henle's loop, interstitial cell and collecting tubule respectively. Vascular injuries such as swelling and detachment of endothelium were observed since 10 minutes after endotoxin injection. Henle's loop showed stratification of basement membrane without consistent features with time lapses and initially observed fatty vaculoes at 1 hour after endotoxin injection were more eminent in 24 hours group. Main changes of interstitial cells were decrease of lipid droplets while increase of fatty vacuoles; the latter were initially observed in 1 hour group and more eminent in 24 hours group. Collecting tubule showed many fatty vacuoles especially in 24 hours group. It is thought that emergence of fatty vacuoles seems to be a kind of immature lipid droplets to compensate the increased demand of PC release due to continuous ischemic condition. In conclusion, it is thought that ischemic injury due to the vascular changes is pathogenic mechanism producing renal papillary necrosis. Endotoxin induced univisceral Shwartzman reaction in the kidney may be a good experimental model in studying renal papillary necrosis.

Ultrastructure of Adenocarcinoma of the Stomach by Scanning Electron Microscope.: Kyung Rak Sohn, Jyung Sik Kwak, Tae Joong Sohn; Korean J Cytopathol. 1985;19(1):13-26.

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Abstract PDF: The author studied 11-cases of adenocarcinoma of the stomach confirmed by gastrofiberscopic biopsy before in order to differentiate between differentiated and undifferentiated adenocarcinoma by scanning electron microscope. Light and transmission electron microscopie examination were done, too. Seven of them are differentiated accompanied by severe intestinal metaplasia and four of them are undifferentiated with rearly focal intestinal metaplasia. Two of the undifferentiated cases shows focal tubular differentiation on the superficial region of the mucosa. Microvilli on the free border are long, regular on the differentiated type but in state of variable loss of microvilli under the transmission electron microscope. Number and density of the mucous granules are variable. Scanning electron microscopic examination shows prominent disorganization of the folds, cellular pleomorphism and pleomorphic microvilli are suggestive of early marker of neoplastic transformation. The size of them are 0.6 micrometer and 1.2 micrometer on the differentiated type respectively. Disorganization of the folds is an important differential point between differentiated and undifferentiated type on the lower power examination. Development of folds, furrow, and hemispheric colliculi are more porminent on the differentiated adenocarcinoma. Presence of striated border, partial or complete loss of microvilli and intestinal metaplasia on the undifferentiated and differentiated adenocarcinomas are consisent with origin from common precursor cells.

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