- Fine Needle Aspiration Cytology of Kikuchi's Lymphadenitis: with Emphasis on Differential Diagnosis with Tuberculosis.
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Kang Min Han, Jai Hyang Go, Na Hye Myong, Wonae Lee
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Korean J Pathol. 2011;45(6):626-631.
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DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.626
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 Abstract
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- BACKGROUND
Although Kikuchi's lymphadenitis (KL) has been known to have characteristic cytological features, pathologists encounter difficulties in making a diagnosis with fine needle aspiration cytology (FNAC). The objective of this study was to assess the diagnostic pitfalls of KL with FNAC, particularly with emphasis on differential diagnosis with tuberculosis.
METHODS
FNAC of 10 patients with a histological diagnosis of KL and tuberculosis was reviewed.
RESULTS
Acidophilic cells were observed in all the 10 KL cases, even if the smears were insufficient. Crescentic histiocytes were seen in 8, granular background in 7, and karyorrhectic debris in 3 cases. Epithelioid histiocytes or neutrophils were not seen in any of the KL cases. Of the 10 cases of tuberculosis, acidophilic cells were observed in 6 cases, crescentic histiocytes in none of them, cheese-like background in 9, karyorrhectic debris in 8, epithelioid histiocytes in 4, and neutrophils in 8 cases.
CONCLUSIONS
The acidophilic cell could be the most sensitive but not the specific marker of KL with FNAC. The crescentic histiocytes might be the sensitive and considerably specific marker of KL. The cytological features distinguishing tuberculosis from KL may be cheese-like necrosis admixed with neutrophils and epithelioid histiocytes.
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Citations
Citations to this article as recorded by  - Kikuchi–Fujimoto disease in the Eastern Mediterranean zone
Abdel Rahman Al Manasra, Hamzeh Al-Domaidat, Mohd Asim Aideh, Doaa Al Qaoud, Majd Al Shalakhti, Sohaib Al khatib, Jehad Fataftah, Raed Al-Taher, Mohammad Nofal
Scientific Reports.2022;[Epub] CrossRef - The fine-needle aspiration cytology and clinical findings of Kikuchi–Fujimoto disease in pediatric patients: a retrospective clinical study
Yuto Naoi, Tomoyasu Tachibana, Yoji Wani, Machiko Hotta, Katsuya Haruna, Yasutoshi Komatsubara, Kazunori Kuroda, Soichiro Fushimi, Tami Nagatani, Yuko Kataoka, Kazunori Nishizaki, Yasuharu Sato, Mizuo Ando
Acta Oto-Laryngologica.2022; 142(3-4): 340. CrossRef - Identification of Torque Teno Virus/Torque Teno-Like Minivirus in the Cervical Lymph Nodes of Kikuchi-Fujimoto Lymphadenitis Patients (Histiocytic Necrotizing Lymphadenitis): A Possible Key to Idiopathic Disease
Yosep Chong, Ji Young Lee, Chang Suk Kang, Eun Jung Lee
Biomedicine Hub.2020; 5(1): 1. CrossRef - Morphology quiz: Enigma of a cervical lymph node
Sudha Sharma
Cytopathology.2019; 30(6): 676. CrossRef - Kikuchis lymphadenitis: Is biopsy necessary in managing these patients
Hemalatha Anantharamaiah, Sagayaraj Arokiyaswamy, ChinaiahS. B. R. Prasad
International Journal of Medicine and Public Health.2015; 5(1): 115. CrossRef - Causative agents of Kikuchi–Fujimoto disease (histiocytic necrotizing lymphadenitis): A meta-analysis
Yosep Chong, Chang Suk Kang
International Journal of Pediatric Otorhinolaryngology.2014; 78(11): 1890. CrossRef
- Aspiration Cytology of the Osteoclastic Variant of Anaplastic Thyroid Carcinoma: with Special Emphasis on the Undifferentiated Mononuclear Cells.
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Kang Min Han, Dong Hoon Kim, Wonae Lee
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Korean J Pathol. 2010;44(6):682-686.
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DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.6.682
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3,017
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- Anaplastic thyroid carcinoma (ATC) is an uncommon aggressive malignant tumor, and the osteoclastic variant of ATC is extremely rare. We report here on the fine needle aspiration cytology of the osteoclastic variant of ATC in an 83-year-old woman. The smear was composed of many oval to slightly elongated undifferentiated mononuclear cells admixed with multinucleated osteoclast-like giant cells. The mononuclear tumor cells revealed inconspicuous nuclear pleomorphism and the nuclei were characterized by vesicular chromatin and an indented or lobulated nuclear membrane with conspicuous nuclear grooves. A few epithelial clusters suggestive of a papillary carcinoma component were also observed. Making the proper cytological diagnosis of the osteoclastic variant of ATC is helpful to determine the proper treatment modality for these patients.
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Citations
Citations to this article as recorded by - Anaplastic carcinoma of thyroid with giant cells –Cytodiagnosis of category VI high grade thyroid tumor
Dhiraj B Nikumbh
IP Archives of Cytology and Histopathology Research.2024; 9(4): 176. CrossRef - A case of osteoclastic variant of anaplastic thyroid carcinoma: Diagnostic and prognostic marker studies by cytology
Surekha Bantumilli, Lee‐Ching Zhu, Muthukumar Sakthivel, Leslie Dodd
Diagnostic Cytopathology.2022;[Epub] CrossRef - Cytodiagnosis of anaplastic thyroid carcinoma with osteoclast-like giant cells − A case report with a review of the literature
Padmanaban Krishnan Govindaraman, Selvaraj Balakumar, Anthuvan Jeyarani Lawrence
Thyroid Research and Practice.2021; 18(1): 40. CrossRef - Role of cytology in differentiating anaplastic thyroid carcinoma with osteoclast like giant cells from giant cell variant of medullary thyroid carcinoma
GP S Gahlot, Tathagata Chatterjee, Rohit Tewari, Vijendra Singh, Ankur Ahuja, Kanwaljeet Singh, Beenu Singh
Journal of Marine Medical Society.2020; 22(2): 255. CrossRef - Osteoclastic variant of anaplastic thyroid carcinoma
Divya Shelly, Divya Gupta, Shashank Mishra, Reena Bharadwaj
Journal of Cancer Research and Therapeutics.2019; 15(3): 704. CrossRef
- Fine Needle Aspiration Cytology of Pulmonary Epithelioid Hemangioendothelioma with Prominent Hyaline Degeneration: A Case Report.
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Kang Min Han, Dong Hoon Kim, Na Hye Myong
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Korean J Pathol. 2010;44(5):554-557.
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DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.554
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3,457
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Abstract
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- Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor of low to intermediate malignant potential, and PEH can mimic other more common tumor entities pathologically as well as clinically. Compared to its well-recognized histological features, its cytological findings have been reported rarely to be plasmacytoid or epithelioid cells with abundant dense or finely granular cytoplasm, cytoplasmic vacuoles, round nuclei and prominent nucleoli.We report here on the fine needle aspiration cytologic findings of a 38-year-old woman with EH of the lung, that showed in addition to its classical cytomorphology, a somewhat peculiar cytologic finding such as big twig-like rosettoid structures with prominent hyalinized stroma. This tumor was histologically and immunohistochemically proven to be PEH by primary antibodies for CD31, CD34 and vimentin. We emphasize that the accuracy of making a cytologic diagnosis of this rare tumor can be increased by recognizing the peculiar cytologic finding that we report on here.
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Citations
Citations to this article as recorded by - Pulmonary epithelioid hemangioendothelioma misconceived as pulmonary metastasis of other malignancies
Gi Tark Noh, Kyoung Ju Lee, Hee Jung Sohn, Kyung Han Lee, Won Seok Heo, Byung Sung Koh, Un Mi Han, Young A Bae
Yeungnam University Journal of Medicine.2016; 33(1): 72. CrossRef - Fine needle aspiration cytology of epithelioid hemangioendothelioma of soft tissue
Shelly Sehgal, Reena Agarwal, Sarika Verma, Ajay Kumar Verma, Sompal Singh
Diagnostic Cytopathology.2013; 41(2): 179. CrossRef
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