Fig. 1Endoscopy shows a pedunculated polyp in the colonic lumen (A) with a slender stalk (B).
Fig. 2Photomicrography showing scanning power of the polyp with surface ulceration (A). (B, C) Low- and high-power views of polymorphic infiltration with scattered sclerotic bands beneath the colonic mucosa. (D, E) Oil immersion views reveal polygonal neoplastic cells with a mitosis (D, arrow) and multinucleation (E) in an inflammatory background with sclerosis. Immunohistochemical study shows that the tumor cells express CD21 (F), CD23 (G), CD35 (H), and D2-40 (I) but not CD34 (J). The tumor cells are positive for Epstein-Barr virus (K) with the high-power view highlighting the multinucleation (L) (in situ hybridization).
Table 1.Pertinent clinicopathological features of all IPT-like FDC sarcomas in the English-language literature
Case No. |
Sex/Age (yr) |
Site |
Size (cm) |
Immunohistochemistry
|
EBER |
Tx |
Outcome (yr) |
Reference |
CD21 |
CD23 |
CD35 |
CNA.42 |
Other |
LMP1 |
1 |
M/70 |
Spleen |
5.5 |
ND |
ND |
ND |
ND |
FDC+ |
ND |
+ |
Surgery |
NR |
Arber et al. [7] |
SMA- |
2 |
F/68 |
Liver |
12 |
+ |
ND |
+ |
ND |
R4/23+ |
+ |
+ |
Surgery |
NR |
Selves et al. [8] |
CT |
3 |
F/35 |
Liver |
20 |
+ |
- |
+ |
ND |
R4/23+ |
+ |
+ |
Surgery |
Recurrence |
Shek et al. [9] |
SMA+ |
NED, 2.5 |
4 |
M/37 |
Liver |
15 |
+ |
+ |
+ |
ND |
|
ND |
+ |
Surgery |
NED, 2 |
Shek et al. [10] |
5 |
F/19 |
Liver |
12 |
-/+a
|
- |
-/+a
|
+ |
HHF-35+ |
+/- |
+ |
Surgery |
NED, 3.5 |
Cheuk et al. [3] |
6 |
F/56 |
Liver |
15 |
+a
|
+ |
+a
|
+ |
HHF-35- |
+ |
+ |
Surgery |
Recurrence, alive |
Cheuk et al. [3] |
with disease, 4.5 |
7 |
F/40 |
Liver |
12.5 |
-/+a
|
- |
-/+a
|
+ |
HHF-35- |
+ |
+ |
Surgery |
Recurrence, 9 |
Cheuk et al. [3] |
8 |
F/49 |
Liver |
4.2 |
+a
|
+ |
+a
|
+ |
|
+/- |
+ |
Surgery |
NED, 0.75 |
Cheuk et al. [3] |
9 |
M/37 |
Liver |
15 |
+a
|
+/- |
+a
|
+ |
HHF-35+/- |
- |
+ |
Surgery |
NED, 3.5 |
Cheuk et al. [3] |
10 |
F/35 |
Liver |
20 |
+*
|
+ |
+*
|
+ |
HHF-35+/- |
+/- |
+ |
Surgery |
Recurrence |
Cheuk et al. [3] |
DOD, 7.9 |
11 |
F/31 |
Liver |
15 |
-/+a
|
- |
-/+a
|
+ |
HHF-35+/- |
- |
+ |
Surgery |
NED, 5 |
Cheuk et al. [3] |
12 |
F/58 |
Spleen |
22 |
+a
|
- |
+a
|
+ |
|
+/- |
+ |
Surgery |
NED, 0.3 |
Cheuk et al. [3] |
13 |
F/39 |
Spleen |
7.5 |
+a
|
+ |
+a
|
+ |
|
+ |
+ |
Surgery |
NED, 0.2 |
Cheuk et al. [3] |
14 |
F/61 |
Spleen |
3.5 |
+a
|
+ |
+a
|
+ |
HHF-35+/- |
+/- |
+ |
Surgery |
NR |
Cheuk et al. [3] |
15 |
F/49 |
Peripancreas |
9.5 |
+a
|
+ |
+a
|
+ |
HHF-35- |
+/- |
+ |
Surgery |
NR |
Cheuk et al. [3] |
16 |
F/51 |
Liver |
15 |
+ |
+ |
- |
ND |
|
ND |
+ |
Surgery |
NED, 3 |
Chen et al. [11] |
17 |
F/57 |
Liver |
12 |
+ |
+ |
- |
ND |
|
ND |
+ |
Surgery |
NED, 1 |
Chen et al. [11] |
18 |
M/54 |
Spleen |
12 |
+ |
+ |
ND |
ND |
SMA+ |
+/- |
+ |
Surgery |
NED, 4 |
Brittig et al. [12] |
19 |
F/77 |
Spleen |
11 |
ND |
ND |
ND |
+ |
|
+ |
+ |
Surgery |
NED, 3 |
Horiguchi et al. [13] |
20 |
F/30 |
Liver |
5.5 |
+ |
ND |
+ |
ND |
|
ND |
+ |
Surgery |
NED, 2 |
Bai et al. [14] |
21 |
F/50 |
Spleen |
5 |
+ |
ND |
+ |
+ |
SMA+ |
ND |
+ |
Surgery |
NED, 0.3 |
Laurent et al. [15] |
22 |
F/57 |
Liver |
13 |
+ |
+ |
ND |
ND |
|
ND |
+ |
Surgery |
NED, 2 |
Granados et al. [16] |
23 |
M/45 |
Liver |
14.5 |
+ |
+ |
- |
ND |
|
ND |
+ |
Surgery |
NED |
Li et al. [5] |
24 |
F/78 |
Colon |
3.9 |
+ |
+ |
+ |
ND |
|
ND |
+ |
Polypectomy |
NED, 0.5 |
Present case |
Subtotal (%) |
NA |
NA |
11/11 (100) |
13/18 (72) |
6/9 (67) |
13/13 (100) |
|
6/8 (75) |
24/24 (100) |
NA |
NA |
NA |