Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
1Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, Korea
© 2016 The Korean Society of Pathologists/The Korean Society for Cytopathology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Conflicts of Interest
No potential conflict of interest relevant to this article was reported.
Study | Location | Diagnosis of initial FNA | Follow-up study | No. |
Results of follow-up study |
|
---|---|---|---|---|---|---|
Conclusive | Inconclusive | |||||
Anderson et al. [14] (2014) | USA | Non-diagnostic | FNA | 336 | 263 | 73 |
Baloch et al. [15] (2003) | USA | Non-diagnostic | FNA | 123 | 92 | 31 |
Chen et al. [16] (2012) | USA | AUS/FLUS | FNA | 26 | 17 | 9 |
Choi et al. [17] (2014) | Korea | Non-diagnostic | CNB | 128 | 120 | 8 |
FNA | 140 | 40 | 100 | |||
Choi et al. [18] (2014) | Korea | AUS/FLUS | CNB | 107 | 103 | 4 |
Dincer et al. [19] (2013) | Turkey | AUS/FLUS | FNA | 74 | 51 | 23 |
Gocun et al. [20] (2014) | Turkey | AUS/FLUS | FNA | 118 | 73 | 45 |
Gweon et al. [21] (2013) | Korea | AUS/FLUS | FNA | 86 | 81 | 5 |
Ho et al. [22] (2014) | USA | AUS/FLUS | FNA | 116 | 74 | 42 |
Hyeon et al. [23] (2014) | Korea | AUS/FLUS | FNA | 274 | 214 | 60 |
Jo et al. [24] (2011) | USA | Non-diagnostic | FNA | 363 | 267 | 96 |
Lee et al. [25] (2015) | Korea | AUS/FLUS | CNB | 34 | 28 | 6 |
FNA | 118 | 74 | 44 | |||
Lee et al. [26] (2014) | Korea | Non-diagnostic | CNB | 121 | 114 | 7 |
FNA | 357 | 239 | 118 | |||
Moon et al. [27] (2015) | Korea | AUS/FLUS | FNA | 246 | 185 | 61 |
Moslavac et al. [28] (2012) | Croatia | Non-diagnostic | FNA | 38 | 31 | 7 |
Na et al. [29] (2015) | Korea | AUS/FLUS | CNB | 158 | 110 | 48 |
FNA | 158 | 75 | 83 | |||
Na et al. [30] (2012) | Korea | Non-diagnostic | CNB | 45 | 43 | 2 |
FNA | 45 | 32 | 13 | |||
AUS/FLUS | CNB | 104 | 82 | 22 | ||
FNA | 104 | 75 | 29 | |||
Nagarkatti et al. [31] (2013) | USA | AUS/FLUS | FNA | 51 | 28 | 23 |
Oertel et al. [32] (2007) | USA | Non-diagnostic | FNA | 27 | 23 | 4 |
Park et al. [33] (2011) | Korea | Non-diagnostic | CNB | 54 | 53 | 1 |
FNA | 142 | 73 | 69 | |||
Park et al. [34] (2015) | Korea | AUS/FLUS | FNA | 236 | 155 | 81 |
Samir et al. [35] (2012) | USA | Non-diagnostic | CNB | 69 | 51 | 18 |
FNA | 69 | 36 | 33 | |||
Sullivan et al. [36] (2014) | USA | AUS/FLUS | FNA | 86 | 48 | 38 |
Trimboli et al. [37] (2015) | Italy | Indeterminate | CNB | 198 | 125 | 73 |
Yeon et al. [38] (2013) | Korea | Non-diagnostic | CNB | 116 | 108 | 8 |
Yoon et al. [39] (2011) | Korea | Non-diagnostic | FNA | 99 | 91 | 8 |
Study | Location | Diagnosis of initial FNA | Follow-up study | No. | Results of follow-up study |
|
---|---|---|---|---|---|---|
Conclusive | Inconclusive | |||||
Anderson et al. [14] (2014) | USA | Non-diagnostic | FNA | 336 | 263 | 73 |
Baloch et al. [15] (2003) | USA | Non-diagnostic | FNA | 123 | 92 | 31 |
Chen et al. [16] (2012) | USA | AUS/FLUS | FNA | 26 | 17 | 9 |
Choi et al. [17] (2014) | Korea | Non-diagnostic | CNB | 128 | 120 | 8 |
FNA | 140 | 40 | 100 | |||
Choi et al. [18] (2014) | Korea | AUS/FLUS | CNB | 107 | 103 | 4 |
Dincer et al. [19] (2013) | Turkey | AUS/FLUS | FNA | 74 | 51 | 23 |
Gocun et al. [20] (2014) | Turkey | AUS/FLUS | FNA | 118 | 73 | 45 |
Gweon et al. [21] (2013) | Korea | AUS/FLUS | FNA | 86 | 81 | 5 |
Ho et al. [22] (2014) | USA | AUS/FLUS | FNA | 116 | 74 | 42 |
Hyeon et al. [23] (2014) | Korea | AUS/FLUS | FNA | 274 | 214 | 60 |
Jo et al. [24] (2011) | USA | Non-diagnostic | FNA | 363 | 267 | 96 |
Lee et al. [25] (2015) | Korea | AUS/FLUS | CNB | 34 | 28 | 6 |
FNA | 118 | 74 | 44 | |||
Lee et al. [26] (2014) | Korea | Non-diagnostic | CNB | 121 | 114 | 7 |
FNA | 357 | 239 | 118 | |||
Moon et al. [27] (2015) | Korea | AUS/FLUS | FNA | 246 | 185 | 61 |
Moslavac et al. [28] (2012) | Croatia | Non-diagnostic | FNA | 38 | 31 | 7 |
Na et al. [29] (2015) | Korea | AUS/FLUS | CNB | 158 | 110 | 48 |
FNA | 158 | 75 | 83 | |||
Na et al. [30] (2012) | Korea | Non-diagnostic | CNB | 45 | 43 | 2 |
FNA | 45 | 32 | 13 | |||
AUS/FLUS | CNB | 104 | 82 | 22 | ||
FNA | 104 | 75 | 29 | |||
Nagarkatti et al. [31] (2013) | USA | AUS/FLUS | FNA | 51 | 28 | 23 |
Oertel et al. [32] (2007) | USA | Non-diagnostic | FNA | 27 | 23 | 4 |
Park et al. [33] (2011) | Korea | Non-diagnostic | CNB | 54 | 53 | 1 |
FNA | 142 | 73 | 69 | |||
Park et al. [34] (2015) | Korea | AUS/FLUS | FNA | 236 | 155 | 81 |
Samir et al. [35] (2012) | USA | Non-diagnostic | CNB | 69 | 51 | 18 |
FNA | 69 | 36 | 33 | |||
Sullivan et al. [36] (2014) | USA | AUS/FLUS | FNA | 86 | 48 | 38 |
Trimboli et al. [37] (2015) | Italy | Indeterminate | CNB | 198 | 125 | 73 |
Yeon et al. [38] (2013) | Korea | Non-diagnostic | CNB | 116 | 108 | 8 |
Yoon et al. [39] (2011) | Korea | Non-diagnostic | FNA | 99 | 91 | 8 |
No. of subsets | No. of patients | Fixed effect model (95% CI) | Heterogeneity (p-value) | Random effect model (95% CI) | Egger’s test | |
---|---|---|---|---|---|---|
Overall | 35 | 4,566 | 0.690 (0.675–0.704) | < .001 | 0.748 (0.701–0.791) | .009 |
Second CNB | 11 | 1,134 | 0.775 (0.745–0.802) | < .001 | 0.879 (0.801–0.929) | < .001 |
Non-diagnostic | 6 | 533 | 0.897 (0.864–0.923) | < .001 | 0.927 (0.847–0.966) | .122 |
AUS/FLUS | 5 | 601 | 0.712 (0.671–0.749) | < .001 | 0.794 (0.675–0.877) | .030 |
Repeat FNA | 24 | 3,432 | 0.670 (0.653–0.686) | < .001 | 0.684 (0.627–0.736) | .651 |
Non-diagnostic | 11 | 1,739 | 0.674 (0.650–0.697) | < .001 | 0.699 (0.596–0.785) | .773 |
AUS/FLUS | 13 | 1,693 | 0.666 (0.642–0.689) | < .001 | 0.673 (0.608–0.732) | .719 |
FNA, fine needle aspiration; CNB, core needle biopsy; AUS/FLUS, atypia/follicular lesion of undetermined significance.
CNB, core needle biopsy; FNA, fine needle aspiration; AUS/FLUS, atypia of undetermined significance/follicular lesion of undetermined significance; CI, confidence interval.