Response to Comment on “Prognostic Role of Claudin-1 Immunohistochemistry in Malignant Solid Tumors: A Meta-Analysis”

Article information

J Pathol Transl Med. 2019;53(6):412-414
Publication date (electronic) : 2019 November 15
doi :
Department of Pathology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea
1Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea
2Department of Urology, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea
Corresponding Author: Won Jin Cho, MD Department of Urology, Chosun Universtity Hospital, Chosun University School of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju 61453, Korea Tel: +82-62-220-3210, Fax: +82-62-232-3210, E-mail:
Received 2019 September 23; Accepted 2019 September 26.

This study aimed to elucidate the prognostic roles of claudin-1 immunohistochemistry in various malignant tumors through a meta-analysis. Data from all included studies were extracted by two independent authors (J.S.P. and N.Y.K.). Any disagreements for extracting data were resolved by consensus. In the present study, to review more articles, we used the narrow exclusion criteria. Therefore, discordance for the literature collection did not occur. We assessed the risk of bias for all included studies according to the Newcastle-Ottawa Scale. The detailed information was shown in Table 1. All data for survivals were a 5-year survival rate. If the extractable data only included the survival curve, survival rates at 5-year were obtained from the survival curve.

The Newcastle-Ottawa Scale for the quality assessment of eligible studies


Conflicts of Interest

The authors declare that they have no potential conflicts of interest.


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Article information Continued

Table 1.

The Newcastle-Ottawa Scale for the quality assessment of eligible studies

Study Selection
Representativeness of the exposed cohort Selection of the non-exposed cohort Ascertainment of exposure Demonstration that outcome of interest was not present at start of study Comparability of cohorts on the basis of the design or analysis Assessment of outcome Was follow-up long enough for outcomes to occur Adequacy of follow-up of cohorts
Ma et al. (2014) [1] NA NA NA * * * * * 5
Morohashi et al. (2007) [2] NA NA NA * * * * * 5
Matsuoka et al. (2011) [3] NA NA NA * * * * * 5
Resnick et al. (2005) [4] NA NA NA * * * * 4
Shibutani et al. (2013) [5] NA NA NA * * * * * 5
Yoshida et al. (2011) [6] NA NA NA * * * * * 5
Miyamoto et al. (2008) [7] NA NA NA * * * * * 5
Xiong et al. (2011) [8] NA NA NA * * * * * 5
Li et al. (2015) [9] NA NA NA * * * * * 5
Sappayatosok and Phattarataratip (2015) [10] NA NA NA * * * * * 5
Fritzsche et al. (2008) [11] NA NA NA * * * * * 5
Shin et al. (2011) [12] NA NA NA * * * * * 5
Bouchagier et al. (2014) [13] NA NA NA * * * * * 5
Higashi et al. (2007) [14] NA NA NA * - * * * 4
Chae et al. (2014) [15] NA NA NA * - * * * 4
Chao et al. (2009) [16] NA NA NA * - * * * 4
Merikallio et al. (2011) [17] NA NA NA * * * * * 5
Zhang et al. (2013) [18] NA NA NA * * * * * 5
Huang et al. (2014) [19] NA NA NA * * * * * 5
Jung et al. (2011) [20] NA NA NA * * * * * 5
Tzelepi et al. (2008) [21] NA NA NA * * * * * 5
Hoellen et al. (2017) [22] NA NA NA * * * * * 5

NA, not available; *, criteria satisfied; –, criteria not satisfied.