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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2019.05.14    [Epub ahead of print]
Amoebic Encephalitis Caused by Balamuthia mandrillaris
Su Jung Kum, Hye Won Lee, Hye Ra Jung, Misun Choe, Sang Pyo Kim
Department of Pathology, Keimyung University School of Medicine, Daegu, Korea
Corresponding Author: Sang Pyo Kim ,Tel: +82-53-580-3815, Fax: +82-53-580-3823, Email: smkim5@kmu.ac.kr
Received: March 18, 2019;  Revised: April 29, 2019  Accepted: May 14, 2019.  Published online: May 24, 2019.
We present the case of a 71-year-old male who was diagnosed with amoebic encephalitis caused by Balamuthia mandrillaris. He had rheumatic arthritis for 30 years and had undergone continuous treatment with immunosuppressants. First, he complained of partial spasm from the left thigh to the left upper limb. Magnetic resonance imaging revealed multifocal enhancing nodules in the cortical and subcortical area of both cerebral hemispheres, which were suggestive of brain metastases. However, the patient developed fever with stuporous mentality and an open biopsy was performed immediately. Microscopically, numerous amoebic trophozoites, measuring 20 to 25 m in size, with nuclei containing one to four nucleoli and some scattered cysts having a doublelayered wall were noted in the background of hemorrhagic necrosis. Based on the microscopic findings, amoebic encephalitis caused by Balamuthia mandrillaris was diagnosed. The patient died on the 10th day after being admitted at the hospital. The diagnosis of amoebic encephalitis in the early stage is difficult for clinicians. Moreover, most cases undergo rapid deterioration, resulting in fatal consequences. In this report, we present the first case of Balamuthia mandrillaris amoebic encephalitis with fatal progression in a Korean patient.
Key Words: Amoebic encephalitis; Balamuthia mandrillaris; Histopathologic features
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