Fig. 1Histologic findings of the cervical lymph node. (A) At low power, the pattern is diffuse, with loss of most normal topographic markings. (B) At high power, rich vascularity, resulting from an increased number of high endothelial venules with polymorphic cell components is evident. In addition, small lymphocytes with regular nuclear contours, immunoblasts, and sparse plasma cells are also observed.
Fig. 2Immunohistochemical results of the cervical lymph node. (A) A CD3 stain shows predominantly T-cell proliferation. (B) At high power, atypical small and large cells are reactive for CD3. (C) Scattered immunoblasts and Reed-Sternberg-like cells are highlighted (CD30). (D) Irregularly shaped, disorganized clusters of follicular dendritic cells (CD21).
Fig. 3T-cell receptor (TCR)-gamma gene rearrangement study. A gene rearrangement study for TCR using polymerase chain reaction single-strand conformation polymorphism analysis shows a polyclonal band. Lane M, 100 base pair DNA ladder marker; lane v1-8, Vγ1-8 region; lane v9, Vγ9 region; lane v10, Vγ10 region; lane v11, Vγ11 region; (-), negative control; (+), positive control.
Fig. 4Radiologic findings of cervical lymph node and spleen. (A) Contrast-enhanced neck computed tomography (CT) image showing enlarged cervical lymph nodes (arrow). (B) Non-contrast-enhanced neck CT image showing normally sized cervical lymph nodes. (C) Contrast enhanced abdomino-pelvic CT image showing splenomegaly (14 cm). (D) Non-contrast enhanced abdomino-pelvic CT image showing a normally sized spleen (9 cm).
Fig. 5Histologic finding of the liver biopsy. The liver biopsy shows granulomatous inflammation, compatible with dapsone-induced hepatitis.