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Review
White Matter Injury of Prematurity: Its Mechanisms and Clinical Features
Young Ah Lee
J Pathol Transl Med. 2017;51(5):449-455.   Published online August 11, 2017
DOI: https://doi.org/10.4132/jptm.2017.07.25
  • 10,910 View
  • 367 Download
  • 23 Web of Science
  • 20 Crossref
AbstractAbstract PDF
A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.

Citations

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  • Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks
    Laila Hadaya, Konstantina Dimitrakopoulou, Lucy D. Vanes, Dana Kanel, Sunniva Fenn-Moltu, Oliver Gale-Grant, Serena J. Counsell, A. David Edwards, Mansoor Saqi, Dafnis Batalle, Chiara Nosarti
    Translational Psychiatry.2023;[Epub]     CrossRef
  • Kaempferol improves periventricular white matter injury in premature infants by inhibiting microglial activation
    Qiuling Zhuo, Binsha Fu, Liangsun Shi
    Materials Express.2023; 13(5): 916.     CrossRef
  • The impact of neonatal morbidities on child growth and developmental outcomes in very low birth weight infants: a nationwide cohort study
    Jung Ho Han, So Jin Yoon, Joo Hee Lim, Jeong Eun Shin, Ho Seon Eun, Min Soo Park, Kook In Park, Soon Min Lee
    European Journal of Pediatrics.2022; 181(1): 197.     CrossRef
  • Global and Regional White Matter Fractional Anisotropy in Children with Chronic Kidney Disease
    Ellen van der Plas, Matthew A. Solomon, Lauren Hopkins, Timothy Koscik, Jordan Schultz, Patrick D. Brophy, Peggy C. Nopoulos, Lyndsay A. Harshman
    The Journal of Pediatrics.2022; 242: 166.     CrossRef
  • A Case of Prenatally Diagnosed Congenital Adrenal Hyperplasia With Brain Morphometric Differences
    Vidya Rajagopalan, Lloyd Nate Overholtzer, William S. Kim, Jessica L. Wisnowski, David A. Miller, Mitchell E. Geffner, Mimi S. Kim
    Journal of Investigative Medicine High Impact Case Reports.2022; 10: 232470962211052.     CrossRef
  • Role of Vitamin E in Neonatal Neuroprotection: A Comprehensive Narrative Review
    Sarah Kolnik, Thomas Wood
    Life.2022; 12(7): 1083.     CrossRef
  • Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia
    Beata Jablonska, Katrina L. Adams, Panagiotis Kratimenos, Zhen Li, Emma Strickland, Tarik F. Haydar, Katharina Kusch, Klaus-Armin Nave, Vittorio Gallo
    Nature Communications.2022;[Epub]     CrossRef
  • PGC-1α activity and mitochondrial dysfunction in preterm infants
    Atefeh Mohammadi, Randa Higazy, Estelle B. Gauda
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity
    Josine E. G. Vaes, Caren M. van Kammen, Chloe Trayford, Annette van der Toorn, Torben Ruhwedel, Manon J. N. L. Benders, Rick M. Dijkhuizen, Wiebke Möbius, Sabine H. van Rijt, Cora H. Nijboer
    Glia.2021; 69(3): 655.     CrossRef
  • The impact of trophic and immunomodulatory factors on oligodendrocyte maturation: Potential treatments for encephalopathy of prematurity
    Josine E. G. Vaes, Myrna J. V. Brandt, Nikki Wanders, Manon J. N. L. Benders, Caroline G. M. de Theije, Pierre Gressens, Cora H. Nijboer
    Glia.2021; 69(6): 1311.     CrossRef
  • Pioglitazone Ameliorates Lipopolysaccharide-Induced Behavioral Impairment, Brain Inflammation, White Matter Injury and Mitochondrial Dysfunction in Neonatal Rats
    Jiann-Horng Yeh, Kuo-Ching Wang, Asuka Kaizaki, Jonathan W. Lee, Han-Chi Wei, Michelle A. Tucci, Norma B. Ojeda, Lir-Wan Fan, Lu-Tai Tien
    International Journal of Molecular Sciences.2021; 22(12): 6306.     CrossRef
  • Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage
    Xinyu Wang, Heng Liu, Xiaoli Liao, Lixing Qiao, Lihua Zhu, Shun Wu, Yan Zhou, Yi Zhang, Bangbang Li, Lili Lin, Jingjing Ma, Qianying Gu, Jiaping Shu
    Frontiers in Genetics.2021;[Epub]     CrossRef
  • Targeting Microglial Disturbances to Protect the Brain From Neurodevelopmental Disorders Associated With Prematurity
    Andrée Delahaye-Duriez, Adrien Dufour, Cindy Bokobza, Pierre Gressens, Juliette Van Steenwinckel
    Journal of Neuropathology & Experimental Neurology.2021; 80(7): 634.     CrossRef
  • Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage
    Lixing Qiao, Sisi Mo, Yan Zhou, Yi Zhang, Bangbang Li, Shun Wu, Lili Lin, Lihua Zhu, Ruibin Zhao
    Genomics.2020; 112(4): 2875.     CrossRef
  • Feed-forward neural networks using cerebral MR spectroscopy and DTI might predict neurodevelopmental outcome in preterm neonates
    T. Janjic, S. Pereverzyev, M. Hammerl, V. Neubauer, H. Lerchner, V. Wallner, R. Steiger, U. Kiechl-Kohlendorfer, M. Zimmermann, A. Buchheim, A. E. Grams, E. R. Gizewski
    European Radiology.2020; 30(12): 6441.     CrossRef
  • White Matter Injury in Early Brain Injury after Subarachnoid Hemorrhage
    Jinwei Pang, Jianhua Peng, Ping Yang, Li Kuai, Ligang Chen, John H. Zhang, Yong Jiang
    Cell Transplantation.2019; 28(1): 26.     CrossRef
  • The Potential of Stem Cell Therapy to Repair White Matter Injury in Preterm Infants: Lessons Learned From Experimental Models
    Josine E. G. Vaes, Marit A. Vink, Caroline G. M. de Theije, Freek E. Hoebeek, Manon J. N. L. Benders, Cora H. A. Nijboer
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Abilitation of Infants with Combined Perinatal Pathology: Capabilities of Approaches and Methods Personalization
    Аlexander A. Baranov, Leyla S. Namazova-Baranova, Irina A. Belyaeva, Еlena V. Аntonova, Еlena A. Vishneva, Еlena P. Bombardirova, Vladimir I. Smirnov, Аlexsei I. Molodchenkov, Мariay О. Zubrikhina
    Current Pediatrics.2019; 18(2): 91.     CrossRef
  • Advanced nanotherapies to promote neuroregeneration in the injured newborn brain
    Olatz Arteaga Cabeza, Alkisti Mikrogeorgiou, Sujatha Kannan, Donna M. Ferriero
    Advanced Drug Delivery Reviews.2019; 148: 19.     CrossRef
  • Rapid Postnatal Adaptation of Neurodevelopment in Pigs Born Late Preterm
    Charlotte Holme Nielsen, Anne Bladt Brandt, Thomas Thymann, Karina Obelitz-Ryom, Pingping Jiang, Charlotte Vanden Hole, Chris van Ginneken, Stanislava Pankratova, Per Torp Sangild
    Developmental Neuroscience.2018; 40(5-6): 586.     CrossRef
Original Article
An Experimental Infarct Targeting the Internal Capsule: Histopathological and Ultrastructural Changes
Chang-Woo Han, Kyung-Hwa Lee, Myung Giun Noh, Jin-Myung Kim, Hyung-Seok Kim, Hyung-Sun Kim, Ra Gyung Kim, Jongwook Cho, Hyoung-Ihl Kim, Min-Cheol Lee
J Pathol Transl Med. 2017;51(3):292-305.   Published online May 10, 2017
DOI: https://doi.org/10.4132/jptm.2017.02.17
  • 7,644 View
  • 110 Download
  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Background
Stroke involving the cerebral white matter (WM) has increased in prevalence, but most experimental studies have focused on ischemic injury of the gray matter. This study was performed to investigate the WM in a unique rat model of photothrombotic infarct targeting the posterior limb of internal capsule (PLIC), focusing on the identification of the most vulnerable structure in WM by ischemic injury, subsequent glial reaction to the injury, and the fundamental histopathologic feature causing different neurologic outcomes.
Methods
Light microscopy with immunohistochemical stains and electron microscopic examinations of the lesion were performed between 3 hours and 21 days post-ischemic injury.
Results
Initial pathological change develops in myelinated axon, concomitantly with reactive change of astrocytes. The first pathology to present is nodular loosening to separate the myelin sheath with axonal wrinkling. Subsequent pathologies include rupture of the myelin sheath with extrusion of axonal organelles, progressive necrosis, oligodendrocyte degeneration and death, and reactive gliosis. Increase of glial fibrillary acidic protein (GFAP) immunoreactivity is an early event in the ischemic lesion. WM pathologies result in motor dysfunction. Motor function recovery after the infarct was correlated to the extent of PLIC injury proper rather than the infarct volume.
Conclusions
Pathologic changes indicate that the cerebral WM, independent of cortical neurons, is highly vulnerable to the effects of focal ischemia, among which myelin sheath is first damaged. Early increase of GFAP immunoreactivity indicates that astrocyte response initially begins with myelinated axonal injury, and supports the biologic role related to WM injury or plasticity. The reaction of astrocytes in the experimental model might be important for the study of pathogenesis and treatment of the WM stroke.

Citations

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  • Animal models of focal ischemic stroke: brain size matters
    Blazej Nowak, Piotr Rogujski, Raphael Guzman, Piotr Walczak, Anna Andrzejewska, Miroslaw Janowski
    Frontiers in Stroke.2023;[Epub]     CrossRef
  • Motor Cortex Plasticity During Functional Recovery Following Brain Damage
    Noriyuki Higo
    Journal of Robotics and Mechatronics.2022; 34(4): 700.     CrossRef
  • Neurodegeneration, Myelin Loss and Glial Response in the Three-Vessel Global Ischemia Model in Rat
    Tatiana Anan’ina, Alena Kisel, Marina Kudabaeva, Galina Chernysheva, Vera Smolyakova, Konstantin Usov, Elena Krutenkova, Mark Plotnikov, Marina Khodanovich
    International Journal of Molecular Sciences.2020; 21(17): 6246.     CrossRef
  • Quantitative assessment of demyelination in ischemic stroke in vivo using macromolecular proton fraction mapping
    Marina Y Khodanovich, Alena A Kisel, Andrey E Akulov, Dmitriy N Atochin, Marina S Kudabaeva, Valentina Y Glazacheva, Michael V Svetlik, Yana A Medvednikova, Lilia R Mustafina, Vasily L Yarnykh
    Journal of Cerebral Blood Flow & Metabolism.2018; 38(5): 919.     CrossRef
  • Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages
    Dominik Michalski, Anna L. Keck, Jens Grosche, Henrik Martens, Wolfgang Härtig
    Frontiers in Cellular Neuroscience.2018;[Epub]     CrossRef
  • Administration of Downstream ApoE Attenuates the Adverse Effect of Brain ABCA1 Deficiency on Stroke
    Xiaohui Wang, Rongwen Li, Alex Zacharek, Julie Landschoot-Ward, Fengjie Wang, Kuan-Han Wu, Michael Chopp, Jieli Chen, Xu Cui
    International Journal of Molecular Sciences.2018; 19(11): 3368.     CrossRef

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