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2 "Uveal melanoma"
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Case Study
Metastatic choroidal melanoma in the breast: a case report and review of the literature
Loay Abudalu, Vinisha Malhotra, Nabila Nasir, Sami Titi
J Pathol Transl Med. 2023;57(4):238-241.   Published online July 11, 2023
DOI: https://doi.org/10.4132/jptm.2023.06.07
  • 1,324 View
  • 92 Download
AbstractAbstract PDF
The breast is an unusual site for metastases, accounting for less than 2% of malignant breast lesions but include those from malignant melanomas, carcinomas, sarcomas, and lymphomas from various organs. We diagnosed a very rare case of metastatic choroidal melanoma for a 67-year-old female who presented with a right breast lump and who had been previously diagnosed with choroidal melanoma-monosomy 3 in 2017. To the best of our knowledge, only five such cases have been published so far, with one in a male patient.
Original Article
Clinicopathologic features and survival outcomes of ocular melanoma: a series of 31 cases from a tertiary university hospital
Selin Kestel, Feriha Pınar Uyar Göçün, Betül Öğüt, Özlem Erdem
J Pathol Transl Med. 2022;56(4):187-198.   Published online May 3, 2022
DOI: https://doi.org/10.4132/jptm.2022.03.10
  • 3,611 View
  • 181 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary Material
Background
We aimed to determine the effect of clinicopathologic features on overall survival among Caucasian ocular melanoma patients in the Central Anatolia region of Turkey.
Methods
This single-center study included conjunctival (n = 12) and uveal (n = 19) melanoma patients diagnosed between January 2008 and March 2020. Clinicopathologic features and outcomes were reviewed retrospectively. Five cases were tested for BRAF V600 mutations with real-time polymerase chain reaction, and one case was tested with nextgeneration sequencing. Survival was calculated using the Kaplan-Meier method.
Results
Thirty-one patients had a mean initial age of 58.32 years (median, 61 years; range 25 to 78 years). There were 13 male and 18 female patients. The median follow-up time was 43.5 months (range, 6 to 155 months) for conjunctival melanoma and 35 months (range, 8 to 151 months) for uveal melanoma. When this study ended, eight of the 12 conjunctival melanoma patients (66.7%) and nine of the 19 uveal melanoma patients (47.4%) had died. The presence of tumor-infiltrating lymphocytes was related to improved overall survival in conjunctival melanoma (p = .014), whereas the presence of ulceration (p = .030), lymphovascular invasion (p = .051), tumor in the left eye (p = .012), tumor thickness of > 2 mm (p = .012), and mitotic count of >1/mm² (p = .012) reduced the overall survival in conjunctival melanoma. Uveal melanoma tumors with the largest diameter of 9.1–15 mm led to the lowest overall survival among subgroups (p = .035). Involvement of the conjunctiva (p=.005) and lens (p = .003) diminished overall survival in uveal melanoma. BRAF V600 mutation was present in one case of conjunctival melanoma, GNAQ R183Q mutation was present in one case of uveal melanoma. Patients with uveal melanoma presented with an advanced pathological tumor stage compared to those with conjunctival melanoma (p = .019).
Conclusions
This study confirmed the presence of tumor-infiltrating lymphocytes as a favorable factor in conjunctival melanoma and conjunctival and lens involvement as unfavorable prognostic factors in uveal melanoma for overall survival, respectively.

Citations

Citations to this article as recorded by  
  • Uveal melanoma in the Iranian population: two decades of patient management in a tertiary eye center
    Hamid Riazi-Esfahani, Abdulrahim Amini, Babak Masoomian, Mehdi Yaseri, Siamak Sabour, Ali Rashidinia, Mojtaba Arjmand, Seyed Mohsen Rafizadeh, Mohammadkarim Johari, Elias Khalili Pour, Fariba Ghassemi
    International Journal of Retina and Vitreous.2024;[Epub]     CrossRef
  • Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi‐institutional study
    Xin Liu, Han Yue, Shiyu Jiang, Lin Kong, Yu Xu, Yong Chen, Chunmeng Wang, Yan Wang, Xiaoli Zhu, Yunyi Kong, Xiaowei Zhang, Jiang Qian, Zhiguo Luo
    Cancer Medicine.2023; 12(15): 16163.     CrossRef
  • Metastatic melanoma: clinicopathologic features and overall survival comparison
    Selin Kestel, Feriha Pınar Uyar Göçün, Betül Öğüt, Özlem Erdem
    Acta Dermatovenerologica Alpina Pannonica et Adriatica.2022;[Epub]     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine