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Tumor immune response and immunotherapy in gastric cancer
Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee
J Pathol Transl Med. 2020;54(1):20-33.   Published online November 1, 2019
DOI: https://doi.org/10.4132/jptm.2019.10.08
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AbstractAbstract PDF
Remarkable developments in immuno-oncology have changed the landscape of gastric cancer (GC) treatment. Because immunotherapy intervenes with tumor immune response rather than directly targeting tumor cells, it is important to develop a greater understanding of tumor immunity. This review paper summarizes the tumor immune reaction and immune escape mechanisms while focusing on the role of T cells and their co-inhibitory signals, such as the immune checkpoint molecules programmed death-1 and programmed deathligand 1 (PD-L1). This paper also describes past clinical trials of immunotherapy for patients with GC and details their clinical implications. Strong predictive markers are essential to improve response to immunotherapy. Microsatellite instability, Epstein-Barr virus, PD-L1 expression, and tumor mutational burden are now regarded as potent predictive markers for immunotherapy in patients with GC. Novel immunotherapy and combination therapy targeting new immune checkpoint molecules such as lymphocyte-activation gene 3, T cell immunoglobulin, and mucin domain containing-3, and indoleamine 2,3-dioxygenase have been suggested, and trials are ongoing to evaluate their safety and efficacy. Immunotherapy is an important treatment option for patients with GC and has great potential for improving patient outcome, and further research in immuno-oncology should be carried out.

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    Quan Jiang, Hao Chen, Shixin Zhou, Tao Zhu, Wenshuai Liu, Hao Wu, Yong Zhang, Fenglin Liu, Yihong Sun
    Cellular Oncology.2024; 47(1): 303.     CrossRef
  • Expression and prognostic value of APOBEC2 in gastric adenocarcinoma and its association with tumor-infiltrating immune cells
    Lipan Wei, Xiuqian Wu, Lan Wang, Ling Chen, Xuejun Wu, Tiantian Song, Yuanyuan Wang, Wenjun Chang, Aizhen Guo, Yongdong Niu, Haihua Huang
    BMC Cancer.2024;[Epub]     CrossRef
  • Identification and characterization of CLEC11A and its derived immune signature in gastric cancer
    Qing Zheng, Zhenqi Gong, Baizhi Li, Runzi Cheng, Weican Luo, Cong Huang, Huaiming Wang
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  • Computed tomography-detected extramural venous invasion-related gene signature: a potential negative biomarker of immune checkpoint inhibitor treatment in patients with gastric cancer
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    Journal of Translational Medicine.2023;[Epub]     CrossRef
  • A standardized pathology report for gastric cancer: 2nd edition
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    Journal of Pathology and Translational Medicine.2023; 57(1): 1.     CrossRef
  • A Standardized Pathology Report for Gastric Cancer: 2nd Edition
    Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi,
    Journal of Gastric Cancer.2023; 23(1): 107.     CrossRef
  • Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach
    Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im
    Journal of Gastric Cancer.2023; 23(1): 3.     CrossRef
  • Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer?
    Marek Majewski, Kamil Torres, Paulina Mertowska, Sebastian Mertowski, Izabela Korona-Głowniak, Jan Korulczyk, Witold Zgodziński, Ewelina Grywalska
    International Journal of Molecular Sciences.2023; 24(6): 5824.     CrossRef
  • Research Progress of Immunotherapy for Gastric Cancer
    Zhipeng Zhang, Ningning Liu, Mingyu Sun
    Technology in Cancer Research & Treatment.2023; 22: 153303382211505.     CrossRef
  • Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment
    Xinyi Shao, Jin Yin, Di Wang, Erjiong Huang, Yini Zhang, Jiani C. Yin, Chen Huang, Hao Wu, Xiaoli Wu
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Artificial Intelligence-Enabled Gastric Cancer Interpretations
    Mustafa Yousif, Liron Pantanowitz
    Surgical Pathology Clinics.2023; 16(4): 673.     CrossRef
  • The Optimal Tumor Mutational Burden Cutoff Value as a Novel Marker for Predicting the Efficacy of Programmed Cell Death-1 Checkpoint Inhibitors in Advanced Gastric Cancer
    Jae Yeon Jang, Youngkyung Jeon, Sun Young Jeong, Sung Hee Lim, Won Ki Kang, Jeeyun Lee, Seung Tae Kim
    Journal of Gastric Cancer.2023; 23(3): 476.     CrossRef
  • Biomarkers for Predicting Response to Personalized Immunotherapy in Gastric Cancer
    Moonsik Kim, Ji Yun Jeong, An Na Seo
    Diagnostics.2023; 13(17): 2782.     CrossRef
  • The Prognostic Value of the Prognostic Nutritional Index in Patients with Advanced or Metastatic Gastric Cancer Treated with Immunotherapy
    Yuting Pan, Yue Ma, Guanghai Dai
    Nutrients.2023; 15(19): 4290.     CrossRef
  • Molecular classification of gastric cancer predicts survival in patients undergoing radical gastrectomy based on project HOPE
    Kenichiro Furukawa, Keiichi Hatakeyama, Masanori Terashima, Takeshi Nagashima, Kenichi Urakami, Keiichi Ohshima, Akifumi Notsu, Takashi Sugino, Taisuke Yagi, Keiichi Fujiya, Satoshi Kamiya, Makoto Hikage, Yutaka Tanizawa, Etsuro Bando, Yae Kanai, Yasuto A
    Gastric Cancer.2022; 25(1): 138.     CrossRef
  • Immunotherapy for gastric cancer: a 2021 update
    Christo Kole, Nikolaos Charalampakis, Sergios Tsakatikas, Nikolaos-Iasonas Kouris, George Papaxoinis, Michalis V Karamouzis, Anna Koumarianou, Dimitrios Schizas
    Immunotherapy.2022; 14(1): 41.     CrossRef
  • The immune microenvironment in gastric adenocarcinoma
    Yana Zavros, Juanita L. Merchant
    Nature Reviews Gastroenterology & Hepatology.2022; 19(7): 451.     CrossRef
  • Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer
    Raghad Khalid AL-Ishaq, Lenka Koklesova, Peter Kubatka, Dietrich Büsselberg
    Cancers.2022; 14(9): 2140.     CrossRef
  • An Immunity-Associated lncRNA Signature for Predicting Prognosis in Gastric Adenocarcinoma
    Xiaowen Zhao, Pingfan Wu, Dongling Liu, Changtian Li, Ling Xue, Zhe Liu, Meng Zhu, Jie Yang, Ziyi Chen, Yaling Li, Yali She, Kathiravan Srinivasan
    Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef
  • RNA modification writers influence tumor microenvironment in gastric cancer and prospects of targeted drug therapy
    Peng Song, Sheng Zhou, Xiaoyang Qi, Yuwen Jiao, Yu Gong, Jie Zhao, Haojun Yang, Zhifen Qian, Jun Qian, Liming Tang
    Journal of Bioinformatics and Computational Biology.2022;[Epub]     CrossRef
  • Identification of the three subtypes and the prognostic characteristics of stomach adenocarcinoma: analysis of the hypoxia-related long non-coding RNAs
    Zehua Fan, Yanqun Wang, Rong Niu
    Functional & Integrative Genomics.2022; 22(5): 919.     CrossRef
  • Complete Response of High Microsatellite Instability Gastric Cancer and Synchronous Microsatellite Stability Rectal Cancer
    Zachary E Hunzeker, Pooja Bhakta, Sindusha R Gudipally, Sri Bharathi Kavuri, Rohit Venkatesan, Chukwuyejulumafor Nwanze
    Cureus.2022;[Epub]     CrossRef
  • Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression
    Yuhan Wei, Jianwei Zhang, Xueke Fan, Zhi Zheng, Xiaoyue Jiang, Dexi Chen, Yuting Lu, Yingrui Li, Miao Wang, Min Hu, Qi Du, Liuting Yang, Hongzhong Li, Yi Xiao, Yongfu Li, Jiangtao Jin, Deying Wang, Xiangliang Yuan, Qin Li
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Tumor vessel normalization and immunotherapy in gastric cancer
    Xianzhe Yu, Shan He, Jian Shen, Qiushi Huang, Peng Yang, Lin Huang, Dan Pu, Li Wang, Lu Li, Jinghua Liu, Zelong Liu, Lingling Zhu
    Therapeutic Advances in Medical Oncology.2022; 14: 175883592211101.     CrossRef
  • FN1 is a prognostic biomarker and correlated with immune infiltrates in gastric cancers
    Han Wang, Junchang Zhang, Huan Li, Hong Yu, Songyao Chen, Shuhao Liu, Changhua Zhang, Yulong He
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Molecular Pathology of Gastric Cancer
    Moonsik Kim, An Na Seo
    Journal of Gastric Cancer.2022; 22(4): 264.     CrossRef
  • Bioinformatics Analysis and Structure of Gastric Cancer Prognosis Model Based on Lipid Metabolism and Immune Microenvironment
    Yongzhi Chen, Hongjun Yuan, Qian Yu, Jianyu Pang, Miaomiao Sheng, Wenru Tang
    Genes.2022; 13(9): 1581.     CrossRef
  • Clinical implications of interleukins-31, 32, and 33 in gastric cancer
    Qing-Hua Liu, Ji-Wei Zhang, Lei Xia, Steven G Wise, Brett David Hambly, Kun Tao, Shi-San Bao
    World Journal of Gastrointestinal Oncology.2022; 14(9): 1808.     CrossRef
  • Microbiota and the Immune System—Actors in the Gastric Cancer Story
    Marek Majewski, Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Ewelina Grywalska, Kamil Torres
    Cancers.2022; 14(15): 3832.     CrossRef
  • Bioinformatics and Experimental Analyses Reveal MAP4K4 as a Potential Marker for Gastric Cancer
    Junping Zhang, Xiaoping Cai, Weifeng Cui, Zheng Wei
    Genes.2022; 13(10): 1786.     CrossRef
  • Common strategies for effective immunotherapy of gastroesophageal cancers using immune checkpoint inhibitors
    Shuang Ma, Fei Chen
    Pathology - Research and Practice.2022; 238: 154110.     CrossRef
  • High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer
    Shouyu Ke, Feng Xie, Yixian Guo, Jieqiong Chen, Zeyu Wang, Yimeng Yu, Haigang Geng, Danhua Xu, Xu Liu, Xiang Xia, Fengrong Yu, Chunchao Zhu, Zizhen Zhang, Gang Zhao, Bin Li, Wenyi Zhao
    iScience.2022; 25(12): 105529.     CrossRef
  • Characteristics of Adenosine-to-Inosine RNA editing-based subtypes and novel risk score for the prognosis and drug sensitivity in stomach adenocarcinoma
    Jingjing Pan, Xinyuan Gu, Jing Luo, Xinye Qian, Qiang Gao, Tianjie Li, Longying Ye, Chenlu Li
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Inhibition of NF‐κB is required for oleanolic acid to downregulate PD‐L1 by promoting DNA demethylation in gastric cancer cells
    Xirong Lu, Yuyi Li, Wei Yang, Minghao Tao, Yanmiao Dai, Jinkang Xu, Qianfei Xu
    Journal of Biochemical and Molecular Toxicology.2021;[Epub]     CrossRef
  • Prognostic Value of C-Reactive Protein to Albumin Ratio in Gastric Cancer: A Meta-Analysis
    Liang Yue, Yi Lu, Yulin Li, Yilin Wang
    Nutrition and Cancer.2021; 73(10): 1864.     CrossRef
  • Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses
    Yu Imamura, Tasuku Toihata, Ikumi Haraguchi, Yoko Ogata, Manabu Takamatsu, Aya Kuchiba, Norio Tanaka, Osamu Gotoh, Seiichi Mori, Yuichiro Nakashima, Eiji Oki, Masaki Mori, Yoshinao Oda, Kenichi Taguchi, Manabu Yamamoto, Masaru Morita, Naoya Yoshida, Hideo
    International Journal of Cancer.2021; 148(5): 1260.     CrossRef
  • Two Similar Signatures for Predicting the Prognosis and Immunotherapy Efficacy of Stomach Adenocarcinoma Patients
    Taohua Yue, Shuai Zuo, Jing Zhu, Shihao Guo, Zhihao Huang, Jichang Li, Xin Wang, Yucun Liu, Shanwen Chen, Pengyuan Wang
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Tumor microenvironment characterization in stage IV gastric cancer
    Feng Yang, Zhenbao Wang, Xianxue Zhang
    Bioscience Reports.2021;[Epub]     CrossRef
  • E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer
    Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu
    Aging.2021; 13(10): 13626.     CrossRef
  • Chemoradiation induces upregulation of immunogenic cell death-related molecules together with increased expression of PD-L1 and galectin-9 in gastric cancer
    S. H. Petersen, L. F. Kua, S. Nakajima, W. P. Yong, K. Kono
    Scientific Reports.2021;[Epub]     CrossRef
  • Establishment of an Immune Cell Infiltration Score to Help Predict the Prognosis and Chemotherapy Responsiveness of Gastric Cancer Patients
    Quan Jiang, Jie Sun, Hao Chen, Chen Ding, Zhaoqing Tang, Yuanyuan Ruan, Fenglin Liu, Yihong Sun
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Microsatellite instability in Gastric Cancer: Between lights and shadows
    Elisabetta Puliga, Simona Corso, Filippo Pietrantonio, Silvia Giordano
    Cancer Treatment Reviews.2021; 95: 102175.     CrossRef
  • Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma
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    World Journal of Gastroenterology.2021; 27(21): 2871.     CrossRef
  • Immunotherapy of gastric cancer: Past, future perspective and challenges
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    Pathology - Research and Practice.2021; 218: 153322.     CrossRef
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    International Journal of Molecular Sciences.2021; 22(13): 7042.     CrossRef
  • Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages
    Yan Yang, Yang Yang, Meili Chen, Jianquan Chen, Jinyan Wang, Yajun Ma, Hanqing Qian
    Biomaterials Science.2021; 9(19): 6597.     CrossRef
  • Correlation between LRP1B Mutations and Tumor Mutation Burden in Gastric Cancer
    Sizhe Hu, Xiaokang Zhao, Feng Qian, Cancan Jin, Kaishun Hou, Tao Huang
    Computational and Mathematical Methods in Medicine.2021; 2021: 1.     CrossRef
  • Comprehensive Analysis to Identify MAGEA3 Expression Correlated With Immune Infiltrates and Lymph Node Metastasis in Gastric Cancer
    Jinji Jin, Jianxin Tu, Jiahuan Ren, Yiqi Cai, Wenjing Chen, Lifang Zhang, Qiyu Zhang, Guanbao Zhu
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Effect of P2X7 receptor on tumorigenesis and its pharmacological properties
    Wen-jun Zhang, Ce-gui Hu, Zheng-ming Zhu, Hong-liang Luo
    Biomedicine & Pharmacotherapy.2020; 125: 109844.     CrossRef
  • Current status and future potential of predictive biomarkers for immune checkpoint inhibitors in gastric cancer
    Byung Woog Kang, Ian Chau
    ESMO Open.2020; 5(4): e000791.     CrossRef
  • Is ramucirumab still the only second-line treatment in metastatic gastric cancer?
    Khalil El Gharib, Hampig Raphael Kourie
    Pharmacogenomics.2020; 21(17): 1203.     CrossRef
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