E-submission
Search
- Page Path
- HOME > Search
Original Articles
- Expression of c-MET in Invasive Meningioma
- Sumi Yun, Jae Moon Koh, Kyu Sang Lee, An Na Seo, Kyung Han Nam, Gheeyoung Choe
- J Pathol Transl Med. 2015;49(1):44-51. Published online January 15, 2015
- DOI: https://doi.org/10.4132/jptm.2014.10.13
- 9,107 View
- 67 Download
- 23 Web of Science
- 20 Crossref
-
Abstract
PDF - Background
Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have been reported to be involved in cancer invasion. Methods: We examined the immunohistochemical expression of c-MET and HGF in 100 cases of patients with meningiomas who have undergone complete tumor removal. Results: c-MET-High and HGFHigh were found in 17% and 13% of meningiomas, respectively. Brain invasion was observed in 17.6% of c-MET-High meningiomas, but in only 2.4% of c-MET-Low meningiomas (p=.033). Bone/ soft tissue invasion was observed in 23.5% of c-MET-High meningiomas and in 9.6% of c-MET-Low meningiomas (p=.119). HGF-High did not show statistical association with brain invasion or bone/ soft tissue invasion. c-MET-High demonstrated shorter recurrence-free survival (RFS, 93.5±8.2 months vs 96.1±1.9 months); however, this difference was not statistically significant (p=.139). There was no association of HGF-High with RFS. Conclusions: This study demonstrates that c- MET-High is associated with brain invasion of meningiomas, and that c-MET expression may be a useful predictive marker for meningioma recurrence. Patients with invasive meningiomas with high expressions of c-MET may be good candidates for targeted therapy using c-MET inhibitors. -
Citations
Citations to this article as recorded by
- Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors
Swati Sharma, Rashmi Rana, Prem Prakash, Nirmal Kumar Ganguly
Molecular and Cellular Biochemistry.2024; 479(1): 127. CrossRef - The efficacy of preoperative MRI features in the diagnosis of meningioma WHO grade and brain invasion
Jun Jiang, Juan Yu, Xiajing Liu, Kan Deng, Kaichao Zhuang, Fan Lin, Liangping Luo
Frontiers in Oncology.2023;[Epub] CrossRef - The Role of Pharmacotherapy in Treatment of Meningioma: A Systematic Review
Ataollah Shahbandi, Darsh S. Shah, Caroline C. Hadley, Akash J. Patel
Cancers.2023; 15(2): 483. CrossRef - Advances in the systemic therapy for recurrent meningiomas and the challenges ahead
Yi Li, Jan Drappatz
Expert Review of Neurotherapeutics.2023; 23(11): 995. CrossRef - Clinical and pathological impact of an optimal assessment of brain invasion for grade 2 meningioma diagnosis: lessons from a series of 291 cases
Thiébaud Picart, Chloé Dumot, Jacques Guyotat, Vladislav Pavlov, Nathalie Streichenberger, Alexandre Vasiljevic, Tanguy Fenouil, Anne Durand, Emmanuel Jouanneau, François Ducray, Timothée Jacquesson, Moncef Berhouma, David Meyronet
Neurosurgical Review.2022; 45(4): 2797. CrossRef - Nomogram based on MRI can preoperatively predict brain invasion in meningioma
Jing Zhang, Yuntai Cao, Guojin Zhang, Zhiyong Zhao, Jianqing Sun, Wenyi Li, Jialiang Ren, Tao Han, Junlin Zhou, Kuntao Chen
Neurosurgical Review.2022; 45(6): 3729. CrossRef - Overexpression of Hepatocyte growth factor and its soluble receptor (s-cMet) in the serum of patients with different grades of meningioma
Farhad Mashayekhi, Soheila Talesh Sasani, Alia Saberi, Zivar Salehi
Journal of Clinical Neuroscience.2021; 93: 1. CrossRef - Brain-invasive meningiomas: molecular mechanisms and potential therapeutic options
Chaoying Qin, Meng Huang, Yimin Pan, Yuzhe Li, Wenyong Long, Qing Liu
Brain Tumor Pathology.2021; 38(3): 156. CrossRef - YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas
Kathleen M. Schieffer, Vibhuti Agarwal, Stephanie LaHaye, Katherine E. Miller, Daniel C. Koboldt, Tara Lichtenberg, Kristen Leraas, Patrick Brennan, Benjamin J. Kelly, Erin Crist, Jerome Rusin, Jonathan L. Finlay, Diana S. Osorio, Eric A. Sribnick, Jeffre
American Journal of Surgical Pathology.2021; 45(3): 329. CrossRef - Regression of Intracranial Meningiomas Following Treatment with Cabozantinib
Rupesh Kotecha, Raees Tonse, Haley Appel, Yazmin Odia, Ritesh R. Kotecha, Guilherme Rabinowits, Minesh P. Mehta
Current Oncology.2021; 28(2): 1537. CrossRef - Prognostic significance of brain invasion in meningiomas: systematic review and meta-analysis
Satoshi Nakasu, Yoko Nakasu
Brain Tumor Pathology.2021; 38(2): 81. CrossRef - Curcumin Inhibits HGF-Induced EMT by Regulating c-MET-Dependent PI3K/Akt/mTOR Signaling Pathways in Meningioma
Xiaodong Chen, Fen Tian, Peng Lun, Yugong Feng, Ho Lin
Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef - Letter to the Editor. Preoperative seizures as predictive sign of brain invasion by meningioma
Mikhail F. Chernov
Journal of Neurosurgery.2019; 130(3): 1030. CrossRef - Investigating Trk Protein Expression between Oropharyngeal and Non-oropharyngeal Squamous Cell Carcinoma: Clinical Implications and Possible Roles of Human Papillomavirus Infection
Yoon Ah Cho, Ji Myung Chung, Hyunmi Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon
Cancer Research and Treatment.2019; 51(3): 1052. CrossRef - Prediction of brain invasion in patients with meningiomas using preoperative magnetic resonance imaging
Alborz Adeli, Katharina Hess, Christian Mawrin, Eileen Maria Susanne Streckert, Walter Stummer, Werner Paulus, André Kemmling, Markus Holling, Walter Heindel, Rene Schmidt, Dorothee Cäcilia Spille, Peter B. Sporns, Benjamin Brokinkel
Oncotarget.2018; 9(89): 35974. CrossRef - Visceral and bone metastases of a WHO grade 2 meningioma: A case report and review of the literature
A. Paix, W. Waissi, D. Antoni, R. Adeduntan, G. Noël
Cancer/Radiothérapie.2017; 21(1): 55. CrossRef - Letter: Brain Invasion in Meningiomas—Sex-Associated Differences are not Related to Estrogen- and Progesterone Receptor Expression
Katharina Heß, Dorothee Cäcilia Spille, Andrea Wagner, Walter Stummer, Werner Paulus, Benjamin Brokinkel
Neurosurgery.2017; 81(2): E25. CrossRef - Brain invasion in meningiomas—clinical considerations and impact of neuropathological evaluation: a systematic review
Benjamin Brokinkel, Katharina Hess, Christian Mawrin
Neuro-Oncology.2017; 19(10): 1298. CrossRef - Systemic therapy for recurrent meningioma
E. Le Rhun, S. Taillibert, M. C. Chamberlain
Expert Review of Neurotherapeutics.2016; 16(8): 889. CrossRef - Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis
Dorothee Cäcilia Spille, Katharina Heß, Cristina Sauerland, Nader Sanai, Walter Stummer, Werner Paulus, Benjamin Brokinkel
World Neurosurgery.2016; 93: 346. CrossRef
- Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors
- Expression of c-Met Is Different along the Location and Associated with Lymph Node Metastasis of Head and Neck Carcinoma
- Ji-Young Choe, Ji Yun Yun, Soo-Jeong Nam, Ji Eun Kim
- Korean J Pathol. 2012;46(6):515-522. Published online December 26, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.515
- 6,361 View
- 44 Download
- 18 Crossref
-
Abstract
PDF
Background Activation of the c-Met pathway is involved in cancer progression and the prognosis. We aimed to identify any association of c-Met protein expression with a number of clinicopathologic variables including infection of human papillomavirus and Epstein-Barr virus (EBV) in head and neck carcinomas (HNCa).
Methods Eighty-two cases were enrolled in this study. Expression of c-Met and p16 was investigated immunohistochemically. EBV was detected by
in situ hybridization and amplification of thec-Met gene by fluorescencein situ hybridization.Results The c-Met protein was expressed in 41.5% (34/82), and gene amplification was found in 1.4% (1/71). High expression of c-Met was associated with the primary location of the tumor; the hypopharynx showed the highest expression, followed by the oral cavity, larynx, and nasal cavity. Squamous cell carcinoma expressed c-Met more frequently than undifferentiated carcinoma. Also, p16 immunoreactivity or EBV infection was associated with the tumor location and well-differentiated histologic type, but were not linked to c-Met expression. The patients with positive c-Met expression showed frequent lymph node metastasis.
Conclusions Activation of the c-Met pathway might be involved in a subset of HNCa. Cases showing positive c-Met expression should be carefully monitored because of the high probability of lymph node metastasis.
-
Citations
Citations to this article as recorded by- c-MET pathway in human malignancies and its targeting by natural compounds for cancer therapy
Chakrabhavi Dhananjaya Mohan, Muthu K Shanmugam, Siddegowda Gopalapura Shivanne Gowda, Arunachalam Chinnathambi, Kanchugarakoppal S. Rangappa, Gautam Sethi
Phytomedicine.2024; 128: 155379. CrossRef - Nadir paranazal sinüs kanserlerinde yeni tanımlanan reseptör tirozin kinaz mutasyonları ve potansiyel fonksiyonel etkileri
Bakiye GÖKER BAGCA, Sercan GÖDE, Göksel TURHAL, Neslihan Pınar ÖZATEŞ, Ali VERAL, Cumhur GÜNDÜZ, Çığır Biray AVCI
Ege Tıp Dergisi.2023; 62(1): 139. CrossRef - The Emerging Role of c-Met in Carcinogenesis and Clinical Implications as a Possible Therapeutic Target
Antonio Faiella, Ferdinando Riccardi, Giacomo Cartenì, Martina Chiurazzi, Livia Onofrio, Rengyun Liu
Journal of Oncology.2022; 2022: 1. CrossRef - NK4 Regulates Laryngeal Squamous Cell Carcinoma Cell Properties and Inhibits Tumorigenicity by Modulating the DKK1/Wnt/β-Catenin Axis
Shoukai Zhang, Hulai Wei, Xiaoqin Ha, Yueyu Zhang, Yufen Guo
Frontiers in Oncology.2021;[Epub] CrossRef - Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
Marcos Antonio Pereira de Lima, Álife Diêgo Lima Silva, Antônio Carlos Silva do Nascimento Filho, Thiago Lima Cordeiro, João Pedro de Souza Bezerra, Maria Aline Barroso Rocha, Sally de França Lacerda Pinheiro, Roberto Flávio Fontenelle Pinheiro Junior, Ma
Pathogens.2021; 10(11): 1429. CrossRef - The roles of PTEN, cMET, and p16 in resistance to cetuximab in head and neck squamous cell carcinoma
Alexandre A. B. A. da Costa, Felipe D’Almeida Costa, Daniel Vilarim Araújo, Marcos Pedro Guedes Camandaroba, Victor Hugo Fonseca de Jesus, Audrey Oliveira, Ana Caroline Fonseca Alves, Carlos Stecca, Larissa Machado, Andrea Cruz Feraz de Oliveira, Thiago B
Medical Oncology.2019;[Epub] CrossRef - Role of c‐Met expression on prognosis of head and neck cancer: A literature review and meta‐analysis
Lei Li, Zhijun Sun, Xin Huang, Xiao Li, Lihua Sun, Lei Zhang, Xiaodan Zhang, Longwei Ye, Jie Yuan, Limin Mao, Guolin Li
Head & Neck.2019; 41(6): 1999. CrossRef - MET Genomic Alterations in Head and Neck Squamous Cell Carcinoma (HNSCC): Rapid Response to Crizotinib in a Patient with HNSCC with a Novel MET R1004G Mutation
Lisa Pei Chu, Debra Franck, Christine A. Parachoniak, Jeffrey P. Gregg, Michael G. Moore, D. Gregory Farwell, Shyam Rao, Andreas M. Heilmann, Rachel L. Erlich, Jeffrey S. Ross, Vincent A. Miller, Siraj Ali, Jonathan W. Riess
The Oncologist.2019; 24(10): 1305. CrossRef - Understanding c-MET signalling in squamous cell carcinoma of the head & neck
P. Szturz, E. Raymond, C. Abitbol, S. Albert, A. de Gramont, S. Faivre
Critical Reviews in Oncology/Hematology.2017; 111: 39. CrossRef - Prognostic value of c-MET in head and neck cancer: A systematic review and meta-analysis of aggregate data
Petr Szturz, Marie Budíková, Jan B. Vermorken, Ivana Horová, Břetislav Gál, Eric Raymond, Armand de Gramont, Sandrine Faivre
Oral Oncology.2017; 74: 68. CrossRef - Activated HGF-c-Met Axis in Head and Neck Cancer
Levi Arnold, Jonathan Enders, Sufi Thomas
Cancers.2017; 9(12): 169. CrossRef - Clinicopathological impacts of high c-Met expression in head and neck squamous cell carcinoma: a meta-analysis and review
Jung Han Kim, Bum Jun Kim, Hyeong Su Kim
Oncotarget.2017; 8(68): 113120. CrossRef - High expression of c‑Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
Mei Jiang, Hui Zhang, He Xiao, Zhimin Zhang, Dan Que, Jia Luo, Jian Li, Bijing Mao, Yuanyuan Chen, Meilin Lan, Ge Wang, Hualiang Xiao
Oncology Letters.2017;[Epub] CrossRef - Profiling of cMET and HER Family Receptor Expression in Pancreatic Ductal Adenocarcinomas and Corresponding Lymph Node Metastasis to Assess Relevant Pathways for Targeted Therapies
Alexander Muckenhuber, Galina Babitzki, Marlene Thomas, Gabriele Hölzlwimmer, Magdalena Zajac, Moritz Jesinghaus, Frank Bergmann, Jens Werner, Albrecht Stenzinger, Wilko Weichert
Pancreas.2016; 45(8): 1167. CrossRef - Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma
Maria J. De Herdt, Stefan M. Willems, Berdine van der Steen, Rob Noorlag, Esther I. Verhoef, Geert J.L.H. van Leenders, Robert J.J. van Es, Senada Koljenović, Robert J. Baatenburg de Jong, Leendert H.J. Looijenga
Oncotarget.2016; 7(11): 13167. CrossRef - Biological, diagnostic and therapeutic relevance of the MET receptor signaling in head and neck cancer
Lluís Nisa, Daniel Matthias Aebersold, Roland Giger, Yitzhak Zimmer, Michaela Medová
Pharmacology & Therapeutics.2014; 143(3): 337. CrossRef - Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus–negative tonsillar squamous cell carcinoma and their prognostic significances
Mi Jung Kwon, Dong Hoon Kim, Hye-Rim Park, Hyung Sik Shin, Ji Hyun Kwon, Dong Jin Lee, Jin Hwan Kim, Seong Jin Cho, Eun Sook Nam
Human Pathology.2014; 45(7): 1327. CrossRef - Distinct c-Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1
Anja Mai, Ghaffar Muharram, Rachel Barrow-McGee, Habib Baghirov, Juha Rantala, Stéphanie Kermorgant, Johanna Ivaska
Journal of Cell Science.2014; 127(9): 1938. CrossRef
- c-MET pathway in human malignancies and its targeting by natural compounds for cancer therapy
First
Prev
