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Case Study
Merkel Cell Carcinoma Metastatic to Pleural Fluid: A Case Report
Ye-Young Rhee, Soo Hee Kim, Eun Kyung Kim, Se Hoon Kim
J Pathol Transl Med. 2018;52(3):206-209.   Published online November 23, 2017
DOI: https://doi.org/10.4132/jptm.2017.11.10
  • 5,863 View
  • 124 Download
  • 4 Web of Science
  • 5 Crossref
AbstractAbstract PDF
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine carcinoma of the skin that shows locoregional or distant metastasis. Metastasis of MCC to body cavity effusion is extremely rare; only three cases have been reported so far. Metastatic MCC in effusion cytology shows small blue round cells with fine stippled chromatin like other small blue round cell tumors such as small cell lung carcinoma or lymphoma. The diagnosis of metastatic MCC can grant patients good chances at recently advanced therapeutic options. Here, we present a case of metastatic MCC to pleural effusion with characteristic single file-like pattern.

Citations

Citations to this article as recorded by  
  • Merkel cell carcinoma presenting as a malignant pleural effusion post‐COVID‐19 hospitalization: A case report and literature review
    Joel Lanceta, Mesut Toprak, Oana C. Rosca
    Diagnostic Cytopathology.2022;[Epub]     CrossRef
  • Cytology coupled with immunocytochemistry identifies Merkel cell carcinoma: A rare intruder in the cerebrospinal fluid
    Reetu Kundu, Brijdeep Singh, Pranab Dey
    Cytopathology.2022; 33(4): 530.     CrossRef
  • Derrame pleural por carcinoma de células de Merkel
    María J. Soler-Sempere, María O. Alvárez-Fernández, Isabel Padilla-Navas, María Cabezas-Macián, Jose F. Sánchez-Hernández, Eduardo García-Pachón
    Archivos de Bronconeumología.2021; 57(11): 715.     CrossRef
  • A rare case of pleural localisation of both metastatic Merkel cell carcinoma and chronic lymphocytic leukaemia
    Elise Kaspi, Shirley Fritz, Julien Colle, Florent Amatore, Diane Frankel, Patrice Roll
    Cytopathology.2021; 32(3): 367.     CrossRef
  • Merkel cell carcinoma with pleural effusion
    María J. Soler-Sempere, María O. Alvárez-Fernández, Isabel Padilla-Navas, María Cabezas-Macián, Jose F. Sánchez-Hernández, Eduardo García-Pachón
    Archivos de Bronconeumología (English Edition).2021; 57(11): 715.     CrossRef
Case Report
Cytologic Diagnosis of Malignant Fibrous Histiocytoma in Pleural Fluid: A Case Report.
Hwa Eun Oh, Yoo Hoon Kim, Seong Jin Cho, Young Sik Kim, In Sun Kim
Korean J Cytopathol. 1995;6(1):80-83.
  • 1,380 View
  • 15 Download
AbstractAbstract PDF
Malignant fibrous histiocytoma is the most common soft tissue sarcoma of late adult life, but it is rare in the pleura. We recently experienced a case of cytology of malignant fibrous histiocytoma in pleural fluid. The smear revealed histiocytic malignant cells, spindle malignant cells and inflammatory cells. The histiocytic cells showed abundant, pale cytoplasm and ovoid, irregular, eccentrically placed nuclei. The spindle cells showed elongated nuclei. Intercellular collagen was also present.
Original Article
Pleural Effusion Cytology of the Metastatic Sex Cord Tumor With Annular Tubules.
Sun Lee, Ju Hie Lee, Youn Wha Kim, Yong Koo Park, Hak Soon Chang, Moon Ho Yang
Korean J Cytopathol. 1997;8(2):190-193.
  • 1,465 View
  • 14 Download
AbstractAbstract PDF
The sex cord tumor with annular tubules(SCTAT) is a rare ovarian neoplasm, which charateristically shows simple and complex annular tubules with central acidophilic hyaline bodies. This tumor has been considered as a tumor of low-grade malignancy with late recurrence. We presented a brief case report of metastatic SCTAT of ovary in pleural fluid from ovary with cytopathologic and clinical features. The cytologic features of differential diagnosis are discussed.
Case Report
Cytologic Features of an Angiosarcoma in Pleural Fluid: A Case Report .
Young Chae Chu, In Seo Park, Yoon Ju Kim, Hye Seung Han, Jee Young Han
Korean J Cytopathol. 1999;10(1):61-66.
  • 1,556 View
  • 20 Download
AbstractAbstract PDF
Angiosarcomas are rare tumors, seen most commonly in the skin and soft tissue of head and neck region. But it has been described in numerous body sites including thyroid, breast, liver, spleen, bone, etc.. Their biological behaviors depend on the microscopic grade, site of origin, and multifocality. We report the unique cytological features of an angiosarcoma in pleural fluid. A 61-year-old woman presented with a 6 month history of dyspnea on exertion and chest pain. Chest computerized tomography(CT) revealed multiple subpleural small nodules in the right lung and widespread air space consolidation and pleural effusion in the left lung. CT of liver revealed multiple small low attenuated lesion. The smears obtained from pleural fluid showed hypocellularity with a hemorrhagic background. The tumor cells were highly pleomorphic oval or spindle in shape and presented singly, in loose groups, in knitted syncytial aggregates, and in acinar pattern. Their nuclei had vesicular chromatin with delineated, thick nuclear membranes and occasionally a large eosinophilic, prominent nucleolus. The cytoplasm was plump, thin or projected in spindly fashion. Almost all tumor cells showed variable sized intracytoplasmic vacuoles and their nuclei were sometimes crescentic by a huge vacuole. Occasional binucleated tumor cells and mitotic figures were present. Cellular debris and streaky materials were identified. Needle biopsy specimen from the pleura revealed anastomosing slit-like spaces lined by pleomorphic tumor cells. The tumor cells showed a strong reactivity for CD31 and vimentin and focal weak reactivity for factor VIII-related antigen.
Original Article
Cytologic Features and Distribution of Primary site of Malignant Cells in Body Fluids.
Kyoung Ho Kim, Kwang Gil Lee
Korean J Pathol. 1990;24(4):456-464.
  • 1,421 View
  • 17 Download
AbstractAbstract PDF
Many articles concerning the accuracy of diagnosis of malignant tumor cells in body fluids have appeared in the literature, but few authors have attempted to describe the characteristics of these cells to determine the site of the primary tumor as they relate to tumors of specific primary sites. This paper presents the results of a retrospective study on malignant body cavity effusions of which the primary site was established on the basis of either biopsy or surgical resection of the primary neoplasm during the period of 6 years beginning from January 1983 to December 1988. The results obtained are summarized as follows: 1) The 143 fluid specimens from 129 patients were composed of 51 cases of pleural, 69 of peritoneal, and 9 of pericardial origin. 2) Adenocarcinoma was the most frequent type of malignant effusions (78.3%). The most common primary site was the lung (50%) in pleural fluid and stomach (55.2%) in ascites. 3) The results of this study show that the primary site of tumor cells can be identified in the body fluid of accurate cytomorphologic criteria are used. Identification of the primary site of an effusion would be improved by the consideration of clinical information

J Pathol Transl Med : Journal of Pathology and Translational Medicine