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Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives
Yoon Kyung Jeon, Sun Och Yoon, Jin Ho Paik, Young A Kim, Bong Kyung Shin, Hyun-Jung Kim, Hee Jeong Cha, Ji Eun Kim, Jooryung Huh, Young-Hyeh Ko
J Pathol Transl Med. 2017;51(3):224-241.   Published online May 10, 2017
DOI: https://doi.org/10.4132/jptm.2017.04.09
  • 15,726 View
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  • 9 Web of Science
  • 11 Crossref
AbstractAbstract PDF
Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.

Citations

Citations to this article as recorded by  
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    Juan-Juan Zhang, Yu-Xin Xie, Li-Lin Luo, Xuan-Tao Yang, Yi-Xing Wang, Yue Cao, Zheng-Bo Long, Wan-Pu Wang
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  • Lymphoproliferative disorder involving body fluid: diagnostic approaches and roles of ancillary studies
    Jiwon Koh, Sun Ah Shin, Ji Ae Lee, Yoon Kyung Jeon
    Journal of Pathology and Translational Medicine.2022; 56(4): 173.     CrossRef
  • Diagnostic Workup of Primary Cutaneous B Cell Lymphomas: A Clinician's Approach
    Giulia Tadiotto Cicogna, Martina Ferranti, Mauro Alaibac
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates
    Alexandra C. Hristov, Nneka I. Comfere, Claudia I. Vidal, Uma Sundram
    Journal of Cutaneous Pathology.2020; 47(11): 1103.     CrossRef
  • Primary lung mucosa-associated lymphoid tissue lymphoma accompanied by multiple sclerosis
    Ke-Ke Yu, Lei Zhu, Ji-Kai Zhao, Rui-Ying Zhao, Yu-Chen Han
    Chinese Medical Journal.2019; 132(13): 1625.     CrossRef
  • Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
    Woojoo Lee, Eun Shin, Bo-Hyung Kim, Hyunchul Kim, Riccardo Dolcetti
    PLOS ONE.2019; 14(11): e0225096.     CrossRef
  • Views of dermatopathologists about clonality assays in the diagnosis of cutaneous T‐cell and B‐cell lymphoproliferative disorders
    Nneka Comfere, Uma Sundram, Maria Yadira Hurley, Brian Swick
    Journal of Cutaneous Pathology.2018; 45(1): 39.     CrossRef
  • A Next-Generation Sequencing Primer—How Does It Work and What Can It Do?
    Yuriy O. Alekseyev, Roghayeh Fazeli, Shi Yang, Raveen Basran, Thomas Maher, Nancy S. Miller, Daniel Remick
    Academic Pathology.2018; 5: 2374289518766521.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine