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Original Article
- Prognostic Significance of Aquaporin 5 Expression in Non-small Cell Lung Cancer
- Young Min Jo, Tae In Park, Hwa Young Lee, Ji Yun Jeong, Won Kee Lee
- J Pathol Transl Med. 2016;50(2):122-128. Published online February 8, 2016
- DOI: https://doi.org/10.4132/jptm.2015.10.31
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- 14 Web of Science
- 10 Crossref
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Abstract
PDF - Background
Aquaporins are water channel proteins that play a major role in the movement of water in various human tissues. Recently, it has been found that aquaporins have influence in the carcinogenesis of human malignancies. We analyzed the prognostic impact of aquaporin 5 (AQP5) in non-small lung cancer (NSCLC). Methods: Seventy-six cases of NSCLC were studied, including 44 cases of adenocarcinoma (ADC) and 32 cases of squamous cell carcinoma (SQCC). Tissue microarray was constructed and immunohistochemical staining for AQP5 was performed. Results: AQP5 was positive in 59.2% of the total enrolled NSCLCs (63.7% in ADC and 53.1% in SQCC). The difference in expression of AQP5 according to the histologic grade of the tumor was significant (p<.047), but not in a serial order. When ADC and SQCC were separately evaluated, no significant difference was observed according to the histologic grade of the tumor (p=.076 in ADC and p=.631 in SQCC). No difference was observed between AQP5 expression and other demographic data and tumor characteristics. Disease-free survival (DFS) was higher in AQP5 negative cases than positive cases in ADC (p=.047), but no significance was found in SQCC (p=.068). We were unable to find a significance between AQP5 overexpression and overall survival in either ADC (p=.210) or SQCC (p=.533). Conclusions: AQP5 expression is associated with DFS in ADC of the lung and tumor grade of NSCLC. The present study suggests that AQP5 can be a prognostic factor of NSCLC. -
Citations
Citations to this article as recorded by
- Aquaporin-mediated dysregulation of cell migration in disease states
Ian M. Smith, Shohini Banerjee, Allison K. Moses, Kimberly M. Stroka
Cellular and Molecular Life Sciences.2023;[Epub] CrossRef - The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article
Lukasz Jaskiewicz, Anna Romaszko-Wojtowicz, Anna Doboszynska, Agnieszka Skowronska
Cells.2023; 12(3): 468. CrossRef - Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets
Mahdieh-Sadat Moosavi, Yalda Elham
Pathology & Oncology Research.2020; 26(2): 615. CrossRef - Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications
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Respiratory Medicine.2020; 174: 106193. CrossRef - Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers
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The Journal of Pathology.2019; 249(2): 193. CrossRef - Anti-cancer effect of Aquaporin 5 silencing in colorectal cancer cells in association with inhibition of Wnt/β-catenin pathway
Wei Wang, Qing Li, Tao Yang, Dongsheng Li, Feng Ding, Hongzhi Sun, Guang Bai
Cytotechnology.2018; 70(2): 615. CrossRef - Knockdown of aquaporin-5 sensitizes colorectal cancer cells to 5-fluorouracil via inhibition of the Wnt–β-catenin signaling pathway
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Biochemistry and Cell Biology.2018; 96(5): 572. CrossRef - Implications of KRAS mutations in acquired resistance to treatment in NSCLC
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Oncotarget.2018; 9(5): 6630. CrossRef
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