Journal of Pathology and Translational Medicine

Volume 49(3); May 2015

Reviews

Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia: Nandor Gabor Than, Roberto Romero, Andrea Balogh, Eva Karpati, Salvatore Andrea Mastrolia, Orna Staretz-Chacham, Sinuhe Hahn, Offer Erez, Zoltan Papp, Chong Jai Kim; J Pathol Transl Med. 2015;49(3):181-208. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.02.25

25,931 View
270 Download
48 Web of Science
46 Crossref

Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis, signal transduction, and pre-mRNA splicing, as well as homo- and heterotypic cell-cell and cell-extracellular matrix interactions. Galectins are also pivotal in immune responses since they regulate host-pathogen interactions, innate and adaptive immune responses, acute and chronic inflammation, and immune tolerance. Some galectins are also central to the regulation of angiogenesis, cell migration and invasion. Expression and functional data provide convincing evidence that, due to these functions, galectins play key roles in shared and unique pathways of normal embryonic and placental development as well as oncodevelopmental processes in tumorigenesis. Therefore, galectins may sometimes act as double-edged swords since they have beneficial but also harmful effects for the organism. Recent advances facilitate the use of galectins as biomarkers in obstetrical syndromes and in various malignancies, and their therapeutic applications are also under investigation. This review provides a general overview of galectins and a focused review of this lectin subfamily in the context of inflammation, infection and tumors of the female reproductive tract as well as in normal pregnancies and those complicated by the great obstetrical syndromes.

Citations

Citations to this article as recorded by

The functional roles of protein glycosylation in human maternal–fetal crosstalk
Jiangming Zhong, Jianlin Li, Graham J Burton, Hannu Koistinen, Ka Wang Cheung, Ernest H Y Ng, Yuanqing Yao, William S B Yeung, Cheuk-Lun Lee, Philip C N Chiu
Human Reproduction Update.2024; 30(1): 81. CrossRef
Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value
Eszter Tóth, Dániel Györffy, Máté Posta, Petronella Hupuczi, Andrea Balogh, Gábor Szalai, Gergő Orosz, László Orosz, András Szilágyi, Orsolya Oravecz, Lajos Veress, Sándor Nagy, Olga Török, Padma Murthi, Offer Erez, Zoltán Papp, Nándor Ács, Nándor Gábor T
International Journal of Molecular Sciences.2024; 25(3): 1865. CrossRef
Is human labor at term an inflammatory condition?
Chandrashekara Kyathanahalli, Madeline Snedden, Emmet Hirsch
Biology of Reproduction.2023; 108(1): 23. CrossRef
Roles of N-linked glycosylation and glycan-binding proteins in placentation: trophoblast infiltration, immunomodulation, angiogenesis, and pathophysiology
Zhengyuan Huang, Pei F. Lai, Alexander T. H. Cocker, Stuart M. Haslam, Anne Dell, Hugh J. M. Brady, Mark R. Johnson
Biochemical Society Transactions.2023; 51(2): 639. CrossRef
Placental galectins regulate innate and adaptive immune responses in pregnancy
Orsolya Oravecz, Roberto Romero, Eszter Tóth, Judit Kapitány, Máté Posta, Dahiana M. Gallo, Simona W. Rossi, Adi L. Tarca, Offer Erez, Zoltán Papp, János Matkó, Nándor Gábor Than, Andrea Balogh
Frontiers in Immunology.2022;[Epub] CrossRef
Proteoglycans: Systems-Level Insight into Their Expression in Healthy and Diseased Placentas
Orsolya Oravecz, Andrea Balogh, Roberto Romero, Yi Xu, Kata Juhasz, Zsolt Gelencser, Zhonghui Xu, Gaurav Bhatti, Roger Pique-Regi, Balint Peterfia, Petronella Hupuczi, Ilona Kovalszky, Padma Murthi, Adi L. Tarca, Zoltan Papp, Janos Matko, Nandor Gabor Tha
International Journal of Molecular Sciences.2022; 23(10): 5798. CrossRef
Evolution of Placental Hormones: Implications for Animal Models
Anthony M. Carter
Frontiers in Endocrinology.2022;[Epub] CrossRef
Possible important roles of galectins in the healing of human fetal membranes
Jia-Le Chen, Yu Chen, De-Xiang Xu, Dao-Zhen Chen
Frontiers in Endocrinology.2022;[Epub] CrossRef
Melatonin-Primed MSCs Alleviate Intrauterine Adhesions by Affecting MSC-Expressed Galectin-3 on Macrophage Polarization
Qi Jiang, Jingman Li, Yuchen Pan, Jiali Wang, Jingjing Yang, Sunan Shen, Yayi Hou
Stem Cells.2022; 40(10): 919. CrossRef
Galectin-1 and Galectin-9 Concentration in Maternal Serum: Implications in Pregnancies Complicated with Preterm Prelabor Rupture of Membranes
Dorota Grażyna Boroń, Aleksy Świetlicki, Michał Potograbski, Grażyna Kurzawińska, Przemysław Wirstlein, Daniel Boroń, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz
Journal of Clinical Medicine.2022; 11(21): 6330. CrossRef
Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia
Ellen Menkhorst, Wei Zhou, Leilani Santos, Jian-Guo Zhang, Yves St-Pierre, Morag J. Young, Evdokia Dimitriadis
Pregnancy Hypertension.2022; 30: 130. CrossRef
A természetes ölősejtek szerepe az anyai-magzati immunhomeostasis fenntartásában
Kornél Lakatos, Kevin M. Elias, Ross S. Berkowitz, Kathleen Hasselblatt, György Végh, Vilmos Fülöp
Orvosi Hetilap.2022; 163(19): 734. CrossRef
Galectin-1 expression in the serum and placenta of pregnant women with fetal growth restriction and its significance
Xiao-Xiao Jin, Xiang Ying, Min-Yue Dong
BMC Pregnancy and Childbirth.2021;[Epub] CrossRef
Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation
Ellen Menkhorst, Nandor Gabor Than, Udo Jeschke, Gabriela Barrientos, Laszlo Szereday, Gabriela Dveksler, Sandra M. Blois
Frontiers in Immunology.2021;[Epub] CrossRef
Maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes
Başak Kaya, Uğur Turhan, Salim Sezer, Serdar Kaya, İsmail Dağ, Ahmet Tayyar
The Journal of Maternal-Fetal & Neonatal Medicine.2020; 33(5): 861. CrossRef
Galectin-1 ameliorates lipopolysaccharide-induced acute lung injury via AMPK-Nrf2 pathway in mice
Xiao-Ting Huang, Wei Liu, Yong Zhou, Mei Sun, Hui-Hui Yang, Chen-Yu Zhang, Si-Yuan Tang
Free Radical Biology and Medicine.2020; 146: 222. CrossRef
Oral Administration of Fucoidan Can Exert Anti-Allergic Activity after Allergen Sensitization by Enhancement of Galectin-9 Secretion in Blood
Masashi Mizuno, Kana Sakaguchi, Iwao Sakane
Biomolecules.2020; 10(2): 258. CrossRef
Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis
Matyas Meggyes, Laszlo Szereday, Noemi Bohonyi, Miklos Koppan, Sarolta Szegedi, Anna Marics-Kutas, Mirjam Marton, Anett Totsimon, Beata Polgar
International Journal of Molecular Sciences.2020; 21(7): 2343. CrossRef
Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand
Mirian Mendoza, Dongli Lu, Angela Ballesteros, Sandra M Blois, Kelsey Abernathy, Chiguang Feng, Charles J Dimitroff, Jonathan Zmuda, Maria Panico, Anne Dell, Gerardo R Vasta, Stuart M Haslam, Gabriela Dveksler
Glycobiology.2020; 30(11): 895. CrossRef
Characterisation of endogenous Galectin-1 and -9 expression in monocyte and macrophage subsets under resting and inflammatory conditions
Franziska Krautter, Carlota Recio, Mohammed T. Hussain, Danielle R. Lezama, Francesco Maione, Myriam Chimen, Asif J. Iqbal
Biomedicine & Pharmacotherapy.2020; 130: 110595. CrossRef
Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
Sandra M. Blois, Stefan Verlohren, Gang Wu, Gary Clark, Anne Dell, Stuart M. Haslam, Gabriela Barrientos
Seminars in Immunopathology.2020; 42(4): 469. CrossRef
Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice
Ellen Menkhorst, Wei Zhou, Leilani L. Santos, Sarah Delforce, Teresa So, Kate Rainczuk, Hannah Loke, Argyro Syngelaki, Swati Varshney, Nicholas Williamson, Kirsty Pringle, Morag J. Young, Kypros H. Nicolaides, Yves St-Pierre, Evdokia Dimitriadis
Hypertension.2020; 76(4): 1185. CrossRef
Increased placental expression of Placental Protein 5 (PP5) / Tissue Factor Pathway Inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: Relevance to impaired trophoblast invasion?
Katalin Karaszi, Szilvia Szabo, Kata Juhasz, Peter Kiraly, Barbara Kocsis-Deak, Beata Hargitai, Tibor Krenacs, Petronella Hupuczi, Offer Erez, Zoltan Papp, Ilona Kovalszky, Nandor Gabor Than
Placenta.2019; 76: 30. CrossRef
Tacrolimus treatment for infertility related to maternal‐fetal immune interactions
Koushi Yamaguchi
American Journal of Reproductive Immunology.2019;[Epub] CrossRef
Human trophoblast requires galectin-3 for cell migration and invasion
Ž. Bojić-Trbojević, M. Jovanović Krivokuća, A. Vilotić, N. Kolundžić, I. Stefanoska, F. Zetterberg, U. J. Nilsson, H. Leffler, Lj. Vićovac
Scientific Reports.2019;[Epub] CrossRef
Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
Sandra M. Blois, Gabriela Dveksler, Gerardo R. Vasta, Nancy Freitag, Véronique Blanchard, Gabriela Barrientos
Frontiers in Immunology.2019;[Epub] CrossRef
Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response
Andrea Balogh, Eszter Toth, Roberto Romero, Katalin Parej, Diana Csala, Nikolett L. Szenasi, Istvan Hajdu, Kata Juhasz, Arpad F. Kovacs, Hamutal Meiri, Petronella Hupuczi, Adi L. Tarca, Sonia S. Hassan, Offer Erez, Peter Zavodszky, Janos Matko, Zoltan Pap
Frontiers in Immunology.2019;[Epub] CrossRef
Galectin 13 (PP13) Facilitates Remodeling and Structural Stabilization of Maternal Vessels during Pregnancy
Marei Sammar, Tijana Drobnjak, Maurizio Mandala, Sveinbjörn Gizurarson, Berthold Huppertz, Hamutal Meiri
International Journal of Molecular Sciences.2019; 20(13): 3192. CrossRef
Differential gene expression in bovine endometrial epithelial cells after challenge with LPS; specific implications for genes involved in embryo maternal interactions
Yongzhi Guo, Tom van Schaik, Naveed Jhamat, Adnan Niazi, Metasu Chanrot, Gilles Charpigny, Jean Francois Valarcher, Erik Bongcam-Rudloff, Göran Andersson, Patrice Humblot, Peter J. Hansen
PLOS ONE.2019; 14(9): e0222081. CrossRef
The Impact of Natural Selection on the Evolution and Function of Placentally Expressed Galectins
Zackery A Ely, Jiyun M Moon, Gregory R Sliwoski, Amandeep K Sangha, Xing-Xing Shen, Abigail L Labella, Jens Meiler, John A Capra, Antonis Rokas, Soojin Yi
Genome Biology and Evolution.2019; 11(9): 2574. CrossRef
Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles
Jennifer R. King, Melissa L. Wilson, Szabolcs Hetey, Peter Kiraly, Koji Matsuo, Antonio V. Castaneda, Eszter Toth, Tibor Krenacs, Petronella Hupuczi, Paulette Mhawech-Fauceglia, Andrea Balogh, Andras Szilagyi, Janos Matko, Zoltan Papp, Lynda D. Roman, Vic
International Journal of Molecular Sciences.2019; 20(20): 4999. CrossRef
The emerging role of galectins in high-fatality cancers
Cherylane Dubé-Delarosbil, Yves St-Pierre
Cellular and Molecular Life Sciences.2018; 75(7): 1215. CrossRef
Dissecting the Structure–Activity Relationship of Galectin–Ligand Interactions
Yi-Chen Chan, Hsien-Ya Lin, Zhijay Tu, Yen-Hsi Kuo, Shang-Te Hsu, Chun-Hung Lin
International Journal of Molecular Sciences.2018; 19(2): 392. CrossRef
The link between immunity, autoimmunity and endometriosis: a literature update
Tao Zhang, Caterina De Carolis, Gene Chi Wai Man, Chi Chiu Wang
Autoimmunity Reviews.2018; 17(10): 945. CrossRef
Systemic expression of galectin genes in periparturient goats
Kingsley Ekwemalor, Sarah Adjei-Fremah, Emmanuel Asiamah, Egbogoye Eluka-Okoludoh, Bertha Osei, Mulumebet Worku
Small Ruminant Research.2018; 168: 60. CrossRef
Body Mass Index Impact and Predictability on Preeclamptic Toxemia
AbdAllah Khaled M
Journal of Gynecological Research and Obstetrics.2018; : 009. CrossRef
The association between oxidative stress-induced galectins and differentiation of human promyelocytic HL-60 cells
James R. Vinnai, Robert C. Cumming, Graham J. Thompson, Alexander V. Timoshenko
Experimental Cell Research.2017; 355(2): 113. CrossRef
Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition
Haidy El-Azzamy, Andrea Balogh, Roberto Romero, Yi Xu, Christopher LaJeunesse, Olesya Plazyo, Zhonghui Xu, Theodore G. Price, Zhong Dong, Adi L. Tarca, Zoltan Papp, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Chong Jai Kim, Nardhy Gomez-Lopez, Nandor Gabor
Journal of Pathology and Translational Medicine.2017; 51(3): 264. CrossRef
Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients With Impaired PP13 Molecule or Function
Hamutal Meiri, George Osol, Irene Cetin, Sveinbjörn Gizurarson, Berthold Huppertz
Computational and Structural Biotechnology Journal.2017; 15: 433. CrossRef
Intracellular galectin-7 expression in cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular galectin-7
Nathalie Bibens-Laulan, Yves St-Pierre, Ivan R Nabi
PLOS ONE.2017; 12(11): e0187194. CrossRef
Serum galectin-9 as a noninvasive biomarker for the detection of endometriosis and pelvic pain or infertility-related gynecologic disorders
Reka Brubel, Attila Bokor, Akos Pohl, Gabriella Krisztina Schilli, Laszlo Szereday, Reka Bacher-Szamuel, Janos Rigo, Beata Polgar
Fertility and Sterility.2017; 108(6): 1016. CrossRef
The relationship between cervical precancerous lesion galectin-3 and p27 protein expression and clinical prognosis
Jianting Ma, Xingguang Zhang, Gang He, Chunlin Yang
Oncology Letters.2017;[Epub] CrossRef
Development and Applications of Lectins as Biological Tools in Biomedical Research
Xiuli Dan, Wenlong Liu, Tzi Bun Ng
Medicinal Research Reviews.2016; 36(2): 221. CrossRef
The human fetoembryonic defense system hypothesis: Twenty years on
Poh-Choo Pang, Stuart M. Haslam, Anne Dell, Gary F. Clark
Molecular Aspects of Medicine.2016; 51: 71. CrossRef
A Human Lectin Microarray for Sperm Surface Glycosylation Analysis
Yangyang Sun, Li Cheng, Yihua Gu, Aijie Xin, Bin Wu, Shumin Zhou, Shujuan Guo, Yin Liu, Hua Diao, Huijuan Shi, Guangyu Wang, Sheng-ce Tao
Molecular & Cellular Proteomics.2016; 15(9): 2839. CrossRef
Fetal gender specific expression of tandem-repeat galectins in placental tissue from normally progressed human pregnancies and intrauterine growth restriction (IUGR)
Stefan Hutter, Julia Knabl, Ulrich Andergassen, Doris Mayr, Simone Hofmann, Christina Kuhn, Sven Mahner, Petra Arck, Udo Jeschke
Placenta.2015; 36(12): 1352. CrossRef

Advances in the Endoscopic Assessment of Inflammatory Bowel Diseases: Cooperation between Endoscopic and Pathologic Evaluations: Jae Hee Cheon; J Pathol Transl Med. 2015;49(3):209-217. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.09

11,550 View
90 Download
4 Web of Science
4 Crossref

Abstract PDF

Endoscopic assessment has a crucial role in the management of inflammatory bowel disease (IBD). It is particularly useful for the assessment of IBD disease extension, severity, and neoplasia surveillance. Recent advances in endoscopic imaging techniques have been revolutionized over the past decades, progressing from conventional white light endoscopy to novel endoscopic techniques using molecular probes or electronic filter technologies. These new technologies allow for visualization of the mucosa in detail and monitor for inflammation/dysplasia at the cellular or sub-cellular level. These techniques may enable us to alter the IBD surveillance paradigm from four quadrant random biopsy to targeted biopsy and diagnosis. High definition endoscopy and dye-based chromoendoscopy can improve the detection rate of dysplasia and evaluate inflammatory changes with better visualization. Dye-less chromoendoscopy, including narrow band imaging, iScan, and autofluorescence imaging can also enhance surveillance in comparison to white light endoscopy with optical or electronic filter technologies. Moreover, confocal laser endomicroscopy or endocytoscopy have can achieve real-time histology evaluation in vivo and have greater accuracy in comparison with histology. These new technologies could be combined with standard endoscopy or further histologic confirmation in patients with IBD. This review offers an evidence-based overview of new endoscopic techniques in patients with IBD.

Citations

Citations to this article as recorded by

Colorectal cancer in inflammatory bowel disease: review of the evidence
D. S. Keller, A. Windsor, R. Cohen, M. Chand
Techniques in Coloproctology.2019; 23(1): 3. CrossRef
Probe-based confocal laser endomicroscopy in the differential diagnosis of inflammatory bowel diseases: a case series
Jung Won Park, Tae Il Kim, Jae Hee Cheon
Intestinal Research.2018; 16(4): 641. CrossRef
How to Assess and Document Endoscopies in IBD Patients by Including Standard Scoring Systems
Anna M. Buchner, Gary R. Lichtenstein
Inflammatory Bowel Diseases.2016; 22(4): 1010. CrossRef
Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?
Anna Chiara Piscaglia, Lucrezia Laterza, Valentina Cesario, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Giovanni Calò, Giovanna Fabbretti, Massimo Brisigotti, Maria Loredana Stefanelli, Antonio Gasbarrini
World Journal of Gastroenterology.2016; 22(46): 10198. CrossRef

Pathology-MRI Correlation of Hepatocarcinogenesis: Recent Update: Jimi Huh, Kyung Won Kim, Jihun Kim, Eunsil Yu; J Pathol Transl Med. 2015;49(3):218-229. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.15

22,518 View
301 Download
11 Web of Science
9 Crossref

Abstract PDF

Understanding the important alterations during hepatocarcinogenesis as well as the characteristic magnetic resonance imaging (MRI) and histopathological features will be helpful for managing patients with chronic liver disease and hepatocellular carcinoma. Recent advances in MRI techniques, such as fat/iron quantification, diffusion-weighted images, and gadoxetic acid-enhanced MRI, have greatly enhanced our understanding of hepatocarcinogenesis.

Citations

Citations to this article as recorded by

Gadoxetic acid in hepatocellular carcinoma and liver metastases: pearls and pitfalls
H.M. Kwok, C.M. Chau, H.C.H. Lee, T. Wong, H.F. Chan, W.H. Luk, W.T.A. Yung, L.F. Cheng, K.F.J. Ma
Clinical Radiology.2023; 78(10): 715. CrossRef
Multi-phasic magnetic resonance imaging of hemodynamic interchanges in hepatocarcinogenesis
Ahmed Mahmoud Elzeneini, Mohsen Ahmed Abdelmohsen, Mohamed Ibrahim Yousef
Egyptian Journal of Radiology and Nuclear Medicine.2023;[Epub] CrossRef
Risk Factors for Hypervascularization in Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement: A Systematic Review and Meta-analysis
Tae-Hyung Kim, Sungmin Woo, Sangwon Han, Chong Hyun Suh, Richard Kinh Gian Do, Jeong Min Lee
Academic Radiology.2022; 29(2): 198. CrossRef
Comparison of IDEAL-IQ and IVIM-DWI for Differentiating between Alpha Fetoprotein-Negative Hepatocellular Carcinoma and Focal Nodular Hyperplasia
Shaopeng Li, Peng Wang, Jun Qiu, Yiju Xie, Dawei Yin, Kexue Deng
Oncologie.2022; 24(3): 527. CrossRef
Hepatocarcinogenesis
Alice Fung, Krishna P. Shanbhogue, Myles T. Taffel, Brian T. Brinkerhoff, Neil D. Theise
Magnetic Resonance Imaging Clinics of North America.2021; 29(3): 359. CrossRef
Pathologic, Molecular, and Prognostic Radiologic Features of Hepatocellular Carcinoma
Kathryn J. Fowler, Adam Burgoyne, Tyler J. Fraum, Mojgan Hosseini, Shintaro Ichikawa, Sooah Kim, Azusa Kitao, Jeong Min Lee, Valérie Paradis, Bachir Taouli, Neil D. Theise, Valérie Vilgrain, Jin Wang, Claude B. Sirlin, Victoria Chernyak
RadioGraphics.2021; 41(6): 1611. CrossRef
Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint
Nese Karadag Soylu
Journal of Gastrointestinal Cancer.2020; 51(4): 1176. CrossRef
Gadoxetate-enhanced dynamic contrast-enhanced MRI for evaluation of liver function and liver fibrosis in preclinical trials
Jimi Huh, Su Jung Ham, Young Chul Cho, Bumwoo Park, Bohyun Kim, Chul-Woong Woo, Yoonseok Choi, Dong-Cheol Woo, Kyung Won Kim
BMC Medical Imaging.2019;[Epub] CrossRef
Non-Hypervascular Hypointense Nodules at Gadoxetic Acid MRI: Hepatocellular Carcinoma Risk Assessment with Emphasis on the Role of Diffusion-Weighted Imaging
Chiara Briani, Marco Di Pietropaolo, Massimo Marignani, Francesco Carbonetti, Paola Begini, Vincenzo David, Elsa Iannicelli
Journal of Gastrointestinal Cancer.2018; 49(3): 302. CrossRef

Effectiveness and Limitations of Core Needle Biopsy in the Diagnosis of Thyroid Nodules: Review of Current Literature: Jung Hyun Yoon, Eun-Kyung Kim, Jin Young Kwak, Hee Jung Moon; J Pathol Transl Med. 2015;49(3):230-235. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.03.21

10,458 View
101 Download
47 Web of Science
46 Crossref

Abstract PDF

Fine needle aspiration (FNA) is currently accepted as an easy, safe, and reliable tool for the diagnosis of thyroid nodules. Nonetheless, a proportion of FNA samples are categorized into non-diagnostic or indeterminate cytology, which frustrates both the clinician and patient. To overcome this limitation of FNA, core needle biopsy (CNB) of the thyroid has been proposed as an additional diagnostic method for more accurate and decisive diagnosis for thyroid nodules of concern. In this review, we focus on the effectiveness and limitations of CNB, and what factors should be considered when CNB is utilized in the diagnosis of thyroid nodules.

Citations

Citations to this article as recorded by

A comparative analysis of core needle biopsy and repeat fine needle aspiration in patients with inconclusive initial cytology of thyroid nodules
Xuejiao Su, Can Yue, Wanting Yang, Buyun Ma
Frontiers in Endocrinology.2024;[Epub] CrossRef
High-Performance PMN-PT Single-Crystal-Based 1-3 Composite Transducer Integrated with a Biopsy Needle
Benjamin C. Kreager, Huaiyu Wu, Wei-Yi Chang, Sunho Moon, Josh Mitchell, Chang Peng, Chih-Chung Huang, Marie Muller, Jian Tian, Xiaoning Jiang
Biosensors.2024; 14(2): 74. CrossRef
TSE-GAN: strain elastography using generative adversarial network for thyroid disease diagnosis
Anping Song, Tianyi Li, Xuehai Ding, Mingye Wu, Ren Wang
Frontiers in Bioengineering and Biotechnology.2024;[Epub] CrossRef
Ultrasound Elastography: Basic Principles and Examples of Clinical Applications with Artificial Intelligence—A Review
Maurizio Cè, Natascha Claudia D'Amico, Giulia Maria Danesini, Chiara Foschini, Giancarlo Oliva, Carlo Martinenghi, Michaela Cellina
BioMedInformatics.2023; 3(1): 17. CrossRef
Histology-based and cytology-based needle sampling for targeted next-generation sequencing in the indeterminate thyroid tumors
Chun-Nan Chen, Tsung-Lin Yang
European Archives of Oto-Rhino-Laryngology.2023; 280(8): 3773. CrossRef
Core needle biopsy and ultrasonography are superior to fine needle aspiration in the management of follicular variant papillary thyroid carcinomas
Ji-Ye Kim, Sunhee Chang, Ah-Young Kwon, Eun Young Park, Tae Hyuk Kim, Sangjoon Choi, Minju Lee, Young Lyun Oh
Endocrine.2022; 75(2): 437. CrossRef
Fine Needle Aspiration Cytology vs. Core Needle Biopsy for Thyroid Nodules: A Prospective, Experimental Study Using Surgical Specimen
Hyuk Kwon, Jandee Lee, Soon Won Hong, Hyeong Ju Kwon, Jin Young Kwak, Jung Hyun Yoon
Journal of the Korean Society of Radiology.2022; 83(3): 645. CrossRef
Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management
Marie Nguyen, George He, Alfred King-Yin Lam
International Journal of Molecular Sciences.2022; 23(6): 3242. CrossRef
Ultrasound Features of Thyroid Metastatic Tumors from the Digestive System: A Report of 2 Case
Zhang,BS Chao, Li,MD Yingying, Zhang,MD Mingbo
ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY.2022; 6(4): 217. CrossRef
Unsupervised Convolutional Neural Network for Motion Estimation in Ultrasound Elastography
Xingyue Wei, Yuanyuan Wang, Lin Ge, Bo Peng, Qiong He, Rui Wang, Lijie Huang, Yan Xu, Jianwen Luo
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.2022; 69(7): 2236. CrossRef
The Value of Ultrasonography Using Thyroid Imaging Reporting and Data Systems (TIRADS) in the Diagnosis of Thyroid Cancer Among the Population of Ha'il, Saudi Arabia
Ashraf Elaggan, Amr Mostafa, Raghad Albdair, Rema Almarshedi, Anas Aljohani, Zaid Alshammari
Cureus.2022;[Epub] CrossRef
NKD2 is correlated with the occurrence, progression and prognosis of thyroid carcinoma
Yu Gao, Yiwei Wang, Rende Guo
European Journal of Medical Research.2022;[Epub] CrossRef
Update on the Evaluation of Thyroid Nodules
Victor J. Bernet, Ana-Maria Chindris
Journal of Nuclear Medicine.2021; 62(Supplement): 13S. CrossRef
Core-Needle Biopsy Does Not Show Superior Diagnostic Performance to Fine-Needle Aspiration for Diagnosing Thyroid Nodules
Ilah Shin, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Si Eun Lee, Hye Sun Lee, Jin Young Kwak
Yonsei Medical Journal.2020; 61(2): 161. CrossRef
Comparison Between Fine Needle Aspiration and Core Needle Biopsy for the Diagnosis of Thyroid Nodules: Effective Indications According to US Findings
Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park, Yaeji Lim
Scientific Reports.2020;[Epub] CrossRef
Plasma-Derived miRNA-222 as a Candidate Marker for Papillary Thyroid Cancer
Aistė Kondrotienė, Albertas Daukša, Daina Pamedytytė, Mintautė Kazokaitė, Aurelija Žvirblienė, Dalia Daukšienė, Vaida Simanavičienė, Raimonda Klimaitė, Ieva Golubickaitė, Rytis Stakaitis, Valdas Šarauskas, Rasa Verkauskienė, Birutė Žilaitienė
International Journal of Molecular Sciences.2020; 21(17): 6445. CrossRef
Ultrasound‐guided needle biopsy of large thyroid nodules: Core needle biopsy yields more reliable results than fine needle aspiration
Hyeon Jin Lee, Young Joong Kim, Hye Yeon Han, Jae Young Seo, Cheol Mog Hwang, KeumWon Kim
Journal of Clinical Ultrasound.2019; 47(5): 255. CrossRef
Degenerating Thyroid Nodules: Ultrasound Diagnosis, Clinical Significance, and Management
Jie Ren, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Chan Kwon Jung, Jeong Hyun Lee
Korean Journal of Radiology.2019; 20(6): 947. CrossRef
Thyroid core needle biopsy: patients’ pain and satisfaction compared to fine needle aspiration
Hyo Jin Kim, Yeo Koon Kim, Jae Hoon Moon, June Young Choi, Sang Il Choi
Endocrine.2019; 65(2): 365. CrossRef
Ultrasonography-Guided Core Needle Biopsy Did Not Reduce Diagnostic Lobectomy for Thyroid Nodules Diagnosed as Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance
Jung Hyun Yoon, Jin Young Kwak, Hee Jung Moon, Eun-Kyung Kim
Ultrasound Quarterly.2019; 35(3): 253. CrossRef
Diagnostic value of fine-needle aspiration combined with ultrasound for thyroid cancer
Juan Li, Qian Wang, Liangliang Wang, Jing Wang, Dongxiao Wang, Zhaoqin Xin, Yilin Liu, Qinghua Zhao
Oncology Letters.2019;[Epub] CrossRef
Utility of a formatted pathologic reporting system in thyroid core needle biopsy: A validation study of 1998 consecutive cases
Ji‐Young Choe, Yoonjin Kwak, Mimi Kim, Yul Ri Chung, Hyun Jeong Kim, Yeo Koon Kim, So Yeon Park
Clinical Endocrinology.2018; 88(1): 96. CrossRef
Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho, Younghye Kim, Seung Yeon Ha
Annals of Diagnostic Pathology.2018; 32: 35. CrossRef
Statement and Recommendations on Interventional Ultrasound as a Thyroid Diagnostic and Treatment Procedure
Christoph F. Dietrich, Thomas Müller, Jörg Bojunga, Yi Dong, Giovanni Mauri, Maija Radzina, Manjiri Dighe, Xin-Wu Cui, Frank Grünwald, Andreas Schuler, Andre Ignee, Huedayi Korkusuz
Ultrasound in Medicine & Biology.2018; 44(1): 14. CrossRef
Core needle biopsy of thyroid nodules: outcomes and safety from a large single-center single-operator study
Jooae Choe, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
Acta Radiologica.2018; 59(8): 924. CrossRef
A spectral X-ray CT simulation study for quantitative determination of iron
Ting Su, Valérie Kaftandjian, Philippe Duvauchelle, Yuemin Zhu
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment.2018; 894: 39. CrossRef
Comparison of the Diagnostic Efficacy of Ultrasound‐Guided Core Needle Biopsy With 18‐ Versus 20‐Gauge Needles for Thyroid Nodules
Hye Shin Ahn, Mirinae Seo, Su Min Ha, Hee Sung Kim
Journal of Ultrasound in Medicine.2018; 37(11): 2565. CrossRef
Evaluation of Modified Core-Needle Biopsy in the Diagnosis of Thyroid Nodules
Soomin Ahn, Sejin Jung, Ji-Ye Kim, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh
Korean Journal of Radiology.2018; 19(4): 656. CrossRef
Model-based quantitative optical biopsy in multilayer in vitro soft tissue models for whole field assessment of nonmelanoma skin cancer
Bala Nivetha Kanakaraj
Journal of Medical Imaging.2018; 5(01): 1. CrossRef
Decreased apolipoprotein A4 and increased complement component 3 as potential markers for papillary thyroid carcinoma: A proteomic study
Reyhaneh Farrokhi Yekta, Afsaneh Arefi Oskouie, Mostafa Rezaei Tavirani, Mohammad R. Mohajeri-Tehrani, Ahmad R. Soroush
The International Journal of Biological Markers.2018; 33(4): 455. CrossRef
Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt’s lymphoma: a case report and review of the literature
Stella Bernardi, Andrea Michelli, Deborah Bonazza, Veronica Calabrò, Fabrizio Zanconati, Gabriele Pozzato, Bruno Fabris
BMC Endocrine Disorders.2018;[Epub] CrossRef
Risk of malignancy according to sub‐classification of the atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda system for reporting thyroid cytopathology
S. J. Kim, J. Roh, J. H. Baek, S. J. Hong, Y. K. Shong, W. B. Kim, D. E. Song
Cytopathology.2017; 28(1): 65. CrossRef
Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm: a matched cohort study
Soo-Yeon Kim, Hye Sun Lee, Jieun Moon, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Jin Young Kwak
European Radiology.2017; 27(2): 801. CrossRef
Core‐needle biopsy versus repeat fine‐needle aspiration for thyroid nodules initially read as atypia/follicular lesion of undetermined significance
Young Jun Choi, Jung Hwan Baek, Chong Hyun Suh, Woo Hyun Shim, Boseul Jeong, Jae Kyun Kim, Dong Eun Song, Tae Yong Kim, Ki‐Wook Chung, Jeong Hyun Lee
Head & Neck.2017; 39(2): 361. CrossRef
Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
Dong Gyu Na, Jung Hwan Baek, So Lyung Jung, Ji-hoon Kim, Jin Yong Sung, Kyu Sun Kim, Jeong Hyun Lee, Jung Hee Shin, Yoon Jung Choi, Eun Ju Ha, Hyun Kyung Lim, Soo Jin Kim, Soo Yeon Hahn, Kwang Hwi Lee, Young Jun Choi, Inyoung Youn, Young Joong Kim, Hye Sh
Korean Journal of Radiology.2017; 18(1): 217. CrossRef
Ultrasound-Pathology Discordant Nodules on Core-Needle Biopsy: Malignancy Risk and Management Strategy
Sae Rom Chung, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Thyroid.2017; 27(5): 707. CrossRef
Ultrasound-guided fine needle aspiration versus core needle biopsy: comparison of post-biopsy hematoma rates and risk factors
In Hye Chae, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y. Park, Jin Young Kwak
Endocrine.2017; 57(1): 108. CrossRef
Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
Wojciech Wojtowicz, Adam Zabek, Stanislaw Deja, Tomasz Dawiskiba, Dorota Pawelka, Mateusz Glod, Waldemar Balcerzak, Piotr Mlynarz
Scientific Reports.2017;[Epub] CrossRef
Comparison of Core-Needle Biopsy and Fine-Needle Aspiration for Evaluating Thyroid Incidentalomas Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: A Propensity Score Analysis
Chong Hyun Suh, Young Jun Choi, Jong Jin Lee, Woo Hyun Shim, Jung Hwan Baek, Han Cheol Chung, Young Kee Shong, Dong Eun Song, Tae Yon Sung, Jeong Hyun Lee
Thyroid.2017; 27(10): 1258. CrossRef
Identification of novel diagnostic biomarkers for thyroid carcinoma
Xiliang Wang, Qing Zhang, Zhiming Cai, Yifan Dai, Lisha Mou
Oncotarget.2017; 8(67): 111551. CrossRef
Core-needle biopsy for the preoperative diagnosis of follicular neoplasm in thyroid nodule screening: A validation study
Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung
Pathology - Research and Practice.2016; 212(1): 44. CrossRef
Non-Coding RNAs in Thyroid Cancer
Ranran Zhang, Heather Hardin, Jidong Chen, Zhenying Guo, Ricardo V. Lloyd
Endocrine Pathology.2016; 27(1): 12. CrossRef
Fine‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
Paul A. VanderLaan
Cancer Cytopathology.2016; 124(12): 862. CrossRef
Core Needle Biopsy Is a More Conclusive Follow-up Method Than Repeat Fine Needle Aspiration for Thyroid Nodules with Initially Inconclusive Results: A Systematic Review and Meta-Analysis
Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang
Journal of Pathology and Translational Medicine.2016; 50(3): 217. CrossRef
The role of core-needle biopsy in the diagnosis of thyroid malignancy in 4580 patients with 4746 thyroid nodules: a systematic review and meta-analysis
Chong Hyun Suh, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Kyung Won Kim, Jayoun Lee, Ki-Wook Chung, Young Kee Shong
Endocrine.2016; 54(2): 315. CrossRef
Fine‐needle aspiration versus core needle biopsy: Reconsidering the evidence of superiority
Annemieke van Zante, Britt‐Marie Ljung
Cancer Cytopathology.2016; 124(12): 853. CrossRef

Original Articles

Proposal of an Appropriate Decalcification Method of Bone Marrow Biopsy Specimens in the Era of Expanding Genetic Molecular Study: Sung-Eun Choi, Soon Won Hong, Sun Och Yoon; J Pathol Transl Med. 2015;49(3):236-242. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.03.16

12,899 View
268 Download
41 Web of Science
42 Crossref

Abstract PDF

Background
The conventional method for decalcification of bone specimens uses hydrochloric acid (HCl) and is notorious for damaging cellular RNA, DNA, and proteins, thus complicating molecular and immunohistochemical analyses. A method that can effectively decalcify while preserving genetic material is necessary. Methods: Pairs of bilateral bone marrow biopsies sampled from 53 patients were decalcified according to protocols of two comparison groups: EDTA versus HCl and RDO GOLD (RDO) versus HCl. Pairs of right and left bone marrow biopsy samples harvested from 28 cases were allocated into the EDTA versus HCl comparison group, and 25 cases to the RDO versus HCl comparison group. The decalcification protocols were compared with regards to histomorphology, immunohistochemistry, and molecular analysis. For molecular analysis, we randomly selected 5 cases from the EDTA versus HCl and RDO versus HCl groups. Results: The decalcification time for appropriate histomorphologic analysis was the longest in the EDTA method and the shortest in the RDO method. EDTA was superior to RDO or HCl in DNA yield and integrity, assessed via DNA extraction, polymerase chain reaction, and silver in situ hybridization using DNA probes. The EDTA method maintained intact nuclear protein staining on immunohistochemistry, while the HCl method produced poor quality images. Staining after the RDO method had equivocal results. RNA in situ hybridization using kappa and lambda RNA probes measured RNA integrity; the EDTA and RDO method had the best quality, followed by HCl. Conclusions: The EDTA protocol would be the best in preserving genetic material. RDO may be an acceptable alternative when rapid decalcification is necessary.

Citations

Citations to this article as recorded by

To Freeze or Not to Freeze? Recommendations for Intraoperative Examination and Gross Prosection of Thyroid Glands
Fouad R. Zakka, Nicole A. Cipriani
Surgical Pathology Clinics.2023; 16(1): 15. CrossRef
Effect of Surface Decalcification With Hydrochloric Acid on the Determination of Estrogen Receptor, Progesterone Receptor, Ki67, and Human Epidermal Growth Factor Receptor 2 Expressions in Invasive Breast Carcinoma Based on Immunohistochemistry and Fluore
Wu Ping, Rao Xin, Zhang Li, Chen Yupeng, Song Fangling, Ren Caihong, Hu Shun, Zhang Sheng
Applied Immunohistochemistry & Molecular Morphology.2023; 31(4): 232. CrossRef
Diagnostic value of MDM2 RNA in situ hybridization for low-grade osteosarcoma: Consistency comparison of RNA in situ hybridization, fluorescence in situ hybridization, and immunohistochemistry
Chen Chen, Xin He, Min Chen, Tianhai Du, Weiji Qin, Wenyi Jing, Hongying Zhang
Virchows Archiv.2023; 482(6): 999. CrossRef
Bone marrow fibrosis is associated with non‐response to CD19 CAR T‐cell therapy in B‐acute lymphoblastic leukemia
Joshua Anil, Ahab Alnemri, Andrew Lytle, Brian Lockhart, Ashley E. Anil, Michael Baumgartner, Kirubel Gebre, Jared McFerran, Stephan A. Grupp, Susan R. Rheingold, Vinodh Pillai
American Journal of Hematology.2023; 98(12): 1888. CrossRef
Epithelioid haemangioendothelioma of the mandible – A case report and review of the literature
Ali Rizvi, Tim K. Blackburn, Guy N. J. Betts
Oral Surgery.2022; 15(3): 387. CrossRef
Evaluation of EDTA and nitric acid solutions for decalcification of joints in AG/WT, BALB/c, C57, DBA1/J mice, and in Wistar rats
Eduarda Correa Freitas, Suelen Pizzolatto Dalmolin, Mateus Müller da Silva, Francine Hehn de Oliveira, Emily Ferreira Salles Pilar
Biotechnic & Histochemistry.2022; 97(5): 372. CrossRef
Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations
Na Sun, Benjamin V. Tran, Zishan Peng, Jing Wang, Ceng Zhang, Peng Yang, Tiffany X. Zhang, Josephine Widjaja, Ryan Y. Zhang, Wenxi Xia, Alexandra Keir, Jia‐Wei She, Hsiao‐hua Yu, Jing‐Jong Shyue, Hongguang Zhu, Vatche G. Agopian, Renjun Pei, James S. Toml
Advanced Science.2022;[Epub] CrossRef
The Expressions of CD30 and CD123 of Mastocytosis in Taiwan
Ching-Fen Yang, Chih-Yi Hsu
Applied Immunohistochemistry & Molecular Morphology.2022; 30(4): 278. CrossRef
Unusual Patterns of HER2 Expression in Breast Cancer: Insights and Perspectives
Dora Grassini, Eliano Cascardi, Ivana Sarotto, Laura Annaratone, Anna Sapino, Enrico Berrino, Caterina Marchiò
Pathobiology.2022; 89(5): 278. CrossRef
Expert opinion on NSCLC small specimen biomarker testing — Part 1: Tissue collection and management
Frédérique Penault-Llorca, Keith M. Kerr, Pilar Garrido, Erik Thunnissen, Elisabeth Dequeker, Nicola Normanno, Simon J. Patton, Jenni Fairley, Joshua Kapp, Daniëlle de Ridder, Aleš Ryška, Holger Moch
Virchows Archiv.2022; 481(3): 335. CrossRef
Comparison of bone demineralisation procedures for DNA recovery from burned remains
Meghan Mckinnon, Denice Higgins
Forensic Science International: Genetics.2021; 51: 102448. CrossRef
A review of the current understanding of burned bone as a source of DNA for human identification
Meghan Mckinnon, Maciej Henneberg, Denice Higgins
Science & Justice.2021; 61(4): 332. CrossRef
Time is bone — Quantitative comparison of decalcification solvents in human femur samples using dual-X-ray-absorptiometry and computed tomography
Joshua Gawlitza, Jakob Steinhäuser, Arno Bücker, Gabriela Krasteva-Christ, Thomas Tschernig
Annals of Anatomy - Anatomischer Anzeiger.2021; 235: 151696. CrossRef
Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
Sunhee Chang, Hyo Sup Shim, Tae Jung Kim, Yoon-La Choi, Wan Seop Kim, Dong Hoon Shin, Lucia Kim, Heae Surng Park, Geon Kook Lee, Chang Hun Lee
Journal of Pathology and Translational Medicine.2021; 55(3): 181. CrossRef
Effect of EDTA decalcification on estrogen receptor and progesterone receptor immunohistochemistry and HER2/neu fluorescence in situ hybridization in breast carcinoma
Erik Washburn, Xiaoyu Tang, Carla Caruso, Michelle Walls, Bing Han
Human Pathology.2021; 117: 108. CrossRef
Performances of single tube nested polymerase chain reaction and GeneXpert ultra on Formalin fixed paraffin embedded tissues in the diagnosis of tuberculous spondylodiscitis
Emna Romdhane, Soumaya Rammeh, Chelli Mouna Bouaziz, Hend Riahi, Meriam Rekaya Ben, Meriam Ksentini, Yosra Chebbi, Wafa Achour, Asma Ferjani, Ben Boubaker Ilhem Boutiba, Leila Slim-Saidi, Mohamed Fethi Ladeb
Clinical Rheumatology.2021; 40(10): 4317. CrossRef
Molecular Characterization of Prostate Cancers in the Precision Medicine Era
Emilio Francesco Giunta, Laura Annaratone, Enrico Bollito, Francesco Porpiglia, Matteo Cereda, Giuseppe Luigi Banna, Alessandra Mosca, Caterina Marchiò, Pasquale Rescigno
Cancers.2021; 13(19): 4771. CrossRef
Increased NF-κB Activity in Osteoprogenitor-Lineage Cells Impairs the Balance of Bone Versus Fat in the Marrow of Skeletally Mature Mice
Tzuhua Lin, Jukka Pajarinen, Yusuke Kohno, Akira Nabeshima, Laura Lu, Karthik Nathan, Zhenyu Yao, Joy Y. Wu, Stuart Goodman
Regenerative Engineering and Translational Medicine.2020; 6(1): 69. CrossRef
Percutaneous CT-guided biopsy of lytic bone lesions in patients clinically suspected of lung cancer: Diagnostic performances for pathological diagnosis and molecular testing
Anne-Claire Toffart, Stéphane Asfari, Anne Mc Leer, Emilie Reymond, Adrien Jankowski, Denis Moro-Sibilot, Olivier Stephanov, Julien Ghelfi, Sylvie Lantuejoul, Gilbert R. Ferretti
Lung Cancer.2020; 140: 93. CrossRef
Effect of decalcification protocols on immunohistochemistry and molecular analyses of bone samples
Elodie Miquelestorena-Standley, Marie-Lise Jourdan, Christine Collin, Corinne Bouvier, Frédérique Larousserie, Sébastien Aubert, Anne Gomez-Brouchet, Jean-Marc Guinebretière, Matthias Tallegas, Bénédicte Brulin, Louis-Romée Le Nail, Anne Tallet, François
Modern Pathology.2020; 33(8): 1505. CrossRef
Identifying Opportunities and Challenges for Patients With Sarcoma as a Result of Comprehensive Genomic Profiling of Sarcoma Specimens
Margaret A. Hay, Eric A. Severson, Vincent A. Miller, David A. Liebner, Jo-Anne Vergilio, Sherri Z. Millis, James L. Chen
JCO Precision Oncology.2020; (4): 176. CrossRef
Comparison of Methods for the Histological Evaluation of Odontocete Spiral Ganglion Cells
Tania Ramírez, Simona Sacchini, Yania Paz, Rubén S. Rosales, Nakita Câmara, Marisa Andrada, Manuel Arbelo, Antonio Fernández
Animals.2020; 10(4): 683. CrossRef
Molecular Pathology of Primary Non-small Cell Lung Cancer
David Ilan Suster, Mari Mino-Kenudson
Archives of Medical Research.2020; 51(8): 784. CrossRef
Comparison of ethylenediaminetetraacetic acid and rapid decalcificier solution for studying human temporal bones by immunofluorescence
Sumana Ghosh, Mark B. Lewis, Bradley J. Walters
Laryngoscope Investigative Otolaryngology.2020; 5(5): 919. CrossRef
A novel cryo-embedding method for in-depth analysis of craniofacial mini pig bone specimens
Pavla Ticha, Igor Pilawski, Xue Yuan, Jie Pan, Ustun S. Tulu, Benjamin R. Coyac, Waldemar Hoffmann, Jill A. Helms
Scientific Reports.2020;[Epub] CrossRef
Accelerating precision medicine in metastatic prostate cancer
Joaquin Mateo, Rana McKay, Wassim Abida, Rahul Aggarwal, Joshi Alumkal, Ajjai Alva, Felix Feng, Xin Gao, Julie Graff, Maha Hussain, Fatima Karzai, Bruce Montgomery, William Oh, Vaibhav Patel, Dana Rathkopf, Matthew Rettig, Nikolaus Schultz, Matthew Smith,
Nature Cancer.2020; 1(11): 1041. CrossRef
Tissue Morphology and Antigenicity in Mouse and Rat Tibia: Comparing 12 Different Decalcification Conditions
Kristofor Bogoevski, Anna Woloszyk, Keith Blackwood, Maria A. Woodruff, Vaida Glatt
Journal of Histochemistry & Cytochemistry.2019; 67(8): 545. CrossRef
Cellular and collagen reference values of gingival and periodontal ligament tissues in rats: a pilot study
Antoine Alves, Nina Attik, Carine Wirth, Yves Bayon, Alexis Piat, Brigitte Grosgogeat, Kerstin Gritsch
Histochemistry and Cell Biology.2019; 152(2): 145. CrossRef
Implementing Precision Medicine Programs and Clinical Trials in the Community-Based Oncology Practice: Barriers and Best Practices
Jennifer L. Ersek, Lora J. Black, Michael A. Thompson, Edward S. Kim
American Society of Clinical Oncology Educational Book.2018; (38): 188. CrossRef
Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL
Zandra C Deans, Jose Luis Costa, Ian Cree, Els Dequeker, Anders Edsjö, Shirley Henderson, Michael Hummel, Marjolijn JL Ligtenberg, Marco Loddo, Jose Carlos Machado, Antonio Marchetti, Katherine Marquis, Joanne Mason, Nicola Normanno, Etienne Rouleau, Ed S
Virchows Archiv.2017; 470(1): 5. CrossRef
Protocolo para el estudio de muestras y estandarización del informe patológico de tumores óseos
Isidro Machado, José Juan Pozo, David Marcilla, Julia Cruz, Juan C. Tardío, Aurora Astudillo, Sílvia Bagué
Revista Española de Patología.2017; 50(1): 34. CrossRef
Extremely Well-Differentiated Papillary Thyroid Carcinoma Resembling Adenomatous Hyperplasia Can Metastasize to the Skull: A Case Report
Ju Yeon Pyo, Jisup Kim, Sung-eun Choi, Eunah Shin, Seok-Woo Yang, Cheong Soo Park, Seok-Mo Kim, SoonWon Hong
Yonsei Medical Journal.2017; 58(1): 255. CrossRef
Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species
Guoying Deng, Kerun Niu, Feng Zhou, Buxiao Li, Yingjie Kang, Xijian Liu, Junqing Hu, Bo Li, Qiugen Wang, Chengqing Yi, Qian Wang
Scientific Reports.2017;[Epub] CrossRef
Precision Medicine Starts With Preanalytics: Real-Time Assessment of Tissue Fixation Quality by Ultrasound Time-of-Flight Analysis
Melissa L. Lerch, Daniel R. Bauer, David Chafin, Abbey Theiss, Michael Otter, Geoffrey S. Baird
Applied Immunohistochemistry & Molecular Morphology.2017; 25(3): 160. CrossRef
Good Laboratory Standards for Clinical Next-Generation Sequencing Cancer Panel Tests
Jihun Kim, Woong-Yang Park, Nayoung K. D. Kim, Se Jin Jang, Sung-Min Chun, Chang-Ohk Sung, Jene Choi, Young-Hyeh Ko, Yoon-La Choi, Hyo Sup Shim, Jae-Kyung Won
Journal of Pathology and Translational Medicine.2017; 51(3): 191. CrossRef
An international survey about nail histology processing techniques
Christina Wlodek, Pauline Lecerf, Josette Andre, Beth S. Ruben, David de Berker
Journal of Cutaneous Pathology.2017; 44(9): 749. CrossRef
pSTAT5 and ERK exhibit different expression in myeloproliferative neoplasms
Ewa Wiśniewska-Chudy, Łukasz Szylberg, Grzegorz Dworacki, Ewa Mizera-Nyczak, Andrzej Marszałek
Oncology Reports.2017; 37(4): 2295. CrossRef
How we do: optimizing bone marrow biopsy logistics for sign-out within 2 days
I. de Laak–de Vries, A. G. Siebers, L. Burgers, C. Diepenbroek, M. Link, P. Groenen, J. H. J. M. van Krieken, K. M. Hebeda
Journal of Hematopathology.2016; 9(2): 67. CrossRef
Do More With Less: Tips and Techniques for Maximizing Small Biopsy and Cytology Specimens for Molecular and Ancillary Testing: The University of Colorado Experience
Dara L. Aisner, Mathew D. Rumery, Daniel T. Merrick, Kimi L. Kondo, Hala Nijmeh, Derek J. Linderman, Robert C. Doebele, Natalie Thomas, Patrick C. Chesnut, Marileila Varella-Garcia, Wilbur A. Franklin, D. Ross Camidge
Archives of Pathology & Laboratory Medicine.2016; 140(11): 1206. CrossRef
Analysis of the Effects of Bone Marrow Biopsy Decalcification Methods on Histopathological Examination
Ji Young Park, Kyung Hee Han
The Korean Journal of Clinical Laboratory Science.2016; 48(4): 371. CrossRef
Distinguishing between Microbial Habitats Unravels Ecological Complexity in Coral Microbiomes
Amy Apprill, Laura G. Weber, Alyson E. Santoro, Nicole S. Webster
mSystems.2016;[Epub] CrossRef
Optimal Fixation and Decalcification Methods for Bone Marrow Biopsy
Myung-Sub Choi, Hyunsup Lee, Hyuk-Chul Kwon, Moon-Hwan Bae, Young-Hye Ko, Hee-Jin Kim, Beom-Se Lee, Bon-Kyung Koo
Korean Journal of Clinical Laboratory Science.2015; 47(4): 243. CrossRef

Smad1 Expression in Follicular Lymphoma: Jai Hyang Go; J Pathol Transl Med. 2015;49(3):243-248. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.03.30

7,005 View
43 Download

Abstract PDF: Background
Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center markers are required. Smad1 has been reported to be overexpressed in follicular lymphoma, but little is known regarding the expression patterns of Smad proteins in human lymphoid tissue. Methods: In the present study, we performed immunohistochemistry for traditional germinal center markers and for Smad1 in human reactive lymphoid and follicular lymphoma tissues to investigate Smad1’s usefulness in the diagnosis of follicular lymphoma. Results: In the reactive germinal centers, most cells were positive for Smad1. Among the 27 follicular lymphoma cases, 17 of 21 (80%) were Smad1 positive, 17 of 27 (63%) were positive for CD10, and 23 of 27 (85%) were positive for Bcl6. Notably, three cases expressed CD10 only, and one only expressed Bcl6. All these cases were grade 3 tumors and showed follicular and diffuse growth patterns. Conclusions: These results indicate that Smad1 is a candidate as a germinal center marker. Furthermore, they suggest that the Smad signaling pathway might be involved in follicular lymphoma.

MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis: Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang, Dong-Hoon Kim, Kyungeun Kim, In-Gu Do, Dong Hyun Kim; J Pathol Transl Med. 2015;49(3):249-256. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.03.27

7,457 View
63 Download
5 Web of Science
5 Crossref

Abstract PDF

Background
While MUC2 is expressed in intestinal metaplasia and malignant lesions, the clinico-pathological significance of MUC2 expression is not fully elucidated in gastric carcinoma (GC). Methods: The present study investigated the correlation between MUC2 expression and clinico-pathological parameters in 167 human GCs. In addition, to confirm the clinicopathological significance of MUC2 expression, we performed a systematic review and meta-analysis in 1,832 GCs. Results: MUC2 expression was found in 58 of 167 GCs (34.7%). MUC2-expressing GC showed lower primary tumor (T), regional lymph node (N), and tumor node metastasis (TNM) stages compared with GCs without MUC2 expression (p=.001, p=.001, and p=.011, respectively). However, MUC2 expression was not correlated with Lauren’s classification and tumor differentiation. In meta-analysis, MUC2 expression was significantly correlated with differentiation and lower tumor stage (odds ratio [OR], 1.303; 95% confidence interval [CI], 1.020 to 1.664; p = .034 and OR, 1.352; 95% CI, 1.055 to 1.734; p = .017, respectively) but not with Lauren’s classification, pN stage, or pTNM stage. Conclusions: MUC2 expression was correlated with a lower tumor depth and lower lymph node metastasis in our study; the meta-analysis showed a correlation of MUC2 expression with tumor differentiation and lower tumor depth.

Citations

Citations to this article as recorded by

Diagnostic gastrointestinal markers in primary lung cancer and pulmonary metastases
Karina Malmros, Andreas Lindholm, Halla Vidarsdottir, Karin Jirström, Björn Nodin, Johan Botling, Johanna S. M. Mattsson, Patrick Micke, Maria Planck, Mats Jönsson, Johan Staaf, Hans Brunnström
Virchows Archiv.2023;[Epub] CrossRef
Gastric epithelial histology and precancerous conditions
Hang Yang, Wen-Juan Yang, Bing Hu
World Journal of Gastrointestinal Oncology.2022; 14(2): 396. CrossRef
COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells
Shen Jiangang, Kang Nayoung, Wang Hongfang, Li Junda, Chen Li, Bai Xuefeng, Li Mingsong
BMC Molecular and Cell Biology.2022;[Epub] CrossRef
Comparative genomic analysis of primary tumors and paired brain metastases in lung cancer patients by whole exome sequencing: a pilot study
Pascale Tomasini, Fabrice Barlesi, Sophie Gilles, Isabelle Nanni-Metellus, Riccardo Soffietti, Emilie Denicolai, Eric Pellegrino, Emilie Bialecki, L’Houcine Ouafik, Philippe Metellus
Oncotarget.2020; 11(50): 4648. CrossRef
A High Ki67/BCL2 Index Could Predict Lower Disease-Free and Overall Survival in Intestinal-Type Gastric Cancer
Kyueng-Whan Min, Dong-Hoon Kim, Byoung Kwan Son, Dong Hyun Kim, Eun-Kyung Kim, Jinwon Seo, Sang Bong Ahn, Yun Ju Jo, Young Sook Park, Junghoon Ha
European Surgical Research.2017; 58(3-4): 158. CrossRef

IDH Mutation Analysis in Ewing Sarcoma Family Tumors: Ki Yong Na, Byeong-Joo Noh, Ji-Youn Sung, Youn Wha Kim, Eduardo Santini Araujo, Yong-Koo Park; J Pathol Transl Med. 2015;49(3):257-261. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.14

9,259 View
74 Download
7 Web of Science
7 Crossref

Abstract PDF

Background
Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield α-ketoglutarate (α-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). Dysfunctional IDH leads to reduced production of α-KG and NADH and increased production of 2-hydroxyglutarate, an oncometabolite. This results in increased oxidative damage and stabilization of hypoxia-inducible factor α, causing cells to be prone to tumorigenesis. Methods: This study investigated IDH mutations in 61 Ewing sarcoma family tumors (ESFTs), using a pentose nucleic acid clamping method and direct sequencing. Results: We identified four cases of ESFTs harboring IDH mutations. The number of IDH1 and IDH2 mutations was equal and the subtype of IDH mutations was variable. Clinicopathologic analysis according to IDH mutation status did not reveal significant results. Conclusions: This study is the first to report IDH mutations in ESFTs. The results indicate that ESFTs can harbor IDH mutations in previously known hot-spot regions, although their incidence is rare. Further validation with a larger case-based study would establish more reliable and significant data on prevalence rate and the biological significance of IDH mutations in ESFTs.

Citations

Citations to this article as recorded by

Glutamine-dependent effects of nitric oxide on cancer cells subjected to hypoxia-reoxygenation
Dianna Xing, Gloria A. Benavides, Michelle S. Johnson, Ran Tian, Stephen Barnes, Victor M. Darley-Usmar
Nitric Oxide.2023; 130: 22. CrossRef
Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
A. Katharina Ceranski, Martha J. Carreño-Gonzalez, Anna C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz, Thomas G. P. Grünewald
Molecular Cancer.2023;[Epub] CrossRef
Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
Ingvild Comfort Hvinden, Tom Cadoux-Hudson, Christopher J. Schofield, James S.O. McCullagh
Cell Reports Medicine.2021; 2(12): 100469. CrossRef
Isocitrate dehydrogenase gene variants in cancer and their clinical significance
Thomas Cadoux-Hudson, Christopher J. Schofield, James S.O. McCullagh
Biochemical Society Transactions.2021; 49(6): 2561. CrossRef
Advances in sarcoma gene mutations and therapeutic targets
Peng Gao, Nicole A. Seebacher, Francis Hornicek, Zheng Guo, Zhenfeng Duan
Cancer Treatment Reviews.2018; 62: 98. CrossRef
Clinicopathologic Features of the Non-CNS Primary Ewing Sarcoma Family of Tumors in the Head and Neck Region
Chang Gok Woo, Bora Lee, Joon Seon Song, Kyung-Ja Cho
Applied Immunohistochemistry & Molecular Morphology.2018; 26(9): 632. CrossRef
EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma
Jason M. Tanner, Claire Bensard, Peng Wei, Nathan M. Krah, John C. Schell, Jamie Gardiner, Joshua Schiffman, Stephen L. Lessnick, Jared Rutter
Molecular Cancer Research.2017; 15(11): 1517. CrossRef

Case Study

Follicular Proliferative Lesion Arising in Struma Ovarii: Min Jee Park, Min A Kim, Mi Kyung Shin, Hye Sook Min; J Pathol Transl Med. 2015;49(3):262-266. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.03.26

8,123 View
129 Download
4 Web of Science
6 Crossref

Abstract PDF

Malignant struma ovarii is extremely rare and difficult to diagnose histologically, particularly in cases of follicular carcinoma. This case study is intended to describe three cases of follicular proliferative lesion arising in struma ovarii that we experienced. The first case was clearly malignant given the clinical picture of multiple recurrences, but there was little histological evidence of malignancy. Our second case featured architectural and cellular atypia and necrosis and was diagnosed as malignant despite the absence of vascular and stromal invasion. Our third case exhibit-ed solid microfollicular proliferation without any definite evidence of malignancy (even the molecular data was negative); however, we could not completely exclude malignant potential after conducting a literature review. In cases such as our third case, it has been previously suggested that a diagnostic term recognizing the low-grade malignant potential, such as “proliferative stromal ovarii” or “follicular proliferative lesion arising in the stromal ovarii” would be appropriate.

Citations

Citations to this article as recorded by

Role of gene sequencing in classifying struma ovarii: BRAF p.G469A mutation and TERT promoter alterations favour malignant struma ovarii
Sophie Neyrand, Alexis Trecourt, Jonathan Lopez, Pierre Alexandre Just, Françoise Descotes, Françoise Borson‐Chazot, Isabelle Ray‐Coquard, Myriam Decaussin‐Petrucci, Mojgan Devouassoux‐Shisheboran
Histopathology.2024; 84(2): 291. CrossRef
Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations
Roberta Poli, Maria Scatolini, Enrico Grosso, Francesca Maletta, Marco Gallo, Daniele Liscia, Anna Nelva, Flora Cesario, Giuseppe Forte, Jasna Metovic, Marco Volante, Emanuela Arvat, Mauro Papotti
Endocrine.2021; 71(1): 216. CrossRef
Proliferative struma ovarii: A rare case report
Shankhanila Mazumdar, GaganKumar Rangari, Neeraj Dhameja, NishaRani Agrawal
International Journal of Clinicopathological Correlation.2021; 5(2): 85. CrossRef
Malignant struma ovarii presenting with follicular carcinoma: A case report with molecular analysis
Takafumi Tsukada, Hiroshi Yoshida, Mitsuya Ishikawa, Yuka Asami, Kouya Shiraishi, Tomoyasu Kato
Gynecologic Oncology Reports.2019; 30: 100498. CrossRef
A Rare Case: Struma Ovarii in a 14-Year-Old Girl
Elif Iltar, Isin Ureyen, Tayfun Toptas, Melike Savas, Sema Çekiç, Aysel Uysal
Journal of Adolescent and Young Adult Oncology.2018; 7(1): 134. CrossRef
Proliferative Highly Differentiated Follicular Carcinoma Of Ovarian Origin (Hdfco) Presenting Long After Bilateral Oophorectomy
Natalie M. Liu, Neda Moatamed, Racquel S. Bueno, Wendy L. Sacks
AACE Clinical Case Reports.2017; 3(3): e264. CrossRef

Brief Case Reports

Traumatic Bowel Perforation and Inguinal Hernia Masking a Mesenteric Calcifying Fibrous Tumor: Dong Hyun Kim, Kyueng-Whan Min, Dong-Hoon Kim, Seoung Wan Chae, Jin Hee Sohn, Jung-Soo Pyo, Sung-Im Do, Kyungeun Kim, Hyun Joo Lee; J Pathol Transl Med. 2015;49(3):267-269. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.03.20

7,193 View
45 Download
1 Web of Science
1 Crossref

PDF

Citations

Citations to this article as recorded by

Calcifying Fibrous Tumor
Angeliki Chorti, Theodossis S. Papavramidis, Antonios Michalopoulos
Medicine.2016; 95(20): e3690. CrossRef

Cytomegalovirus-Associated Intussusception with Florid Vascular Proliferation in an Infant: Heejung Park, Sanghui Park, Young Ju Hong, Sun Wha Lee, Min-Sun Cho; J Pathol Transl Med. 2015;49(3):270-273. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.01

6,849 View
43 Download
2 Web of Science
3 Crossref

PDF

Citations

Citations to this article as recorded by

Severe Postnatal Cytomegalovirus Enterocolitis in Immunocompetent Term Infants Requiring Total Parenteral Nutrition
Annaleise R. Howard-Jones, Giancarlo H. Cristerna-Tarrasa, Rabia Khan, Michael Stormon, Susan Arbuckle, Philip N. Britton
JPGN Reports.2021; 2(3): e110. CrossRef
Retrospective multicenter matched case–control study on the risk factors for intussusception in infants less than 1 year of age with a special focus on rotavirus vaccines – the German Intussusception Study
Doris Oberle, Marcus Hoffelner, Jutta Pavel, Dirk Mentzer, Immanuel Barth, Ursula Drechsel-Bäuerle, Brigitte Keller-Stanislawski
Human Vaccines & Immunotherapeutics.2020; 16(10): 2481. CrossRef
Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates
Ronald Reisler, Xiankun Zeng, Christopher Schellhase, Jeremy Bearss, Travis Warren, John Trefry, George Christopher, Mark Kortepeter, Sina Bavari, Anthony Cardile
Viruses.2018; 10(10): 513. CrossRef

A Case of Primary Subpleural Pulmonary Microcystic Myxoma Coincidentally Occurred with Pulmonary Adenocarcinoma: Jungsuk Ahn, Na Rae Kim, Seung Yeon Ha, Keun-Woo Kim, Kook Yang Park, Yon Mi Sung; J Pathol Transl Med. 2015;49(3):274-278. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.03.12

6,934 View
50 Download
2 Web of Science
1 Crossref

PDF

Citations

Citations to this article as recorded by

Endobronchial Myxoma
Arindam Mukherjee, Ritesh Agarwal, Sahajal Dhooria, Pawan Singh, Amanjit Bal, Harkant Singh, Inderpaul S. Sehgal
Journal of Bronchology & Interventional Pulmonology.2018; 25(4): 335. CrossRef

First
Prev
Page of 1
Next
Last

Previous issues