Department of Pathology, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.
1Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
© 2014 The Korean Society of Pathologists/The Korean Society for Cytopathology
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Case No. | Result | Sex | Age (yr) | Pattern | Size (cm) | T stage | N stage | M stage | Stage | Smoking | Chemotherapy |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | c.35G>C (p.G12A) | F | 61 | A&S | 1.8 | 2a | 2 | 1b | IV | Never | Yes |
5 | c.35G>T (p.G12V) | M | 77 | NA | 2.5 | 1b | 2 | 1b | IV | Former | Yes |
6 | c.35G>A (p.G12D) | F | 67 | S | 3.5 | 2a | 1 | 0 | IIA | Never | No |
11 | c.35G>C (p.G12A) | M | 59 | NA | 4.3 | 2a | 1 | 1b | IV | Former | No |
16 | c.35G>A (p.G12D) | M | 61 | S | 6 | 2b | 0 | 0 | IIA | Current | No |
26 | c.35G>A (p.G12D) | F | 52 | NA | 8 | 3 | 0 | 1a | IV | Never | Yes |
29 | c.35G>A (p.G12D) | M | 74 | A | 3.7 | 4 | 0 | 1a | IV | Current | Yes |
38 | c.35G>A (p.G12D) | M | 52 | A | 2.2 | 1b | 2 | 0 | IIIA | Current | No |
49 | c.35G>T (p.G12V) | M | 67 | A | 3.4 | 2a | 0 | 1b | IV | Former | No |
51 | c.34G>T (p.G12C) | M | 56 | A&S | 3 | 1b | 1 | 1b | IV | Current | No |
52 | c.35G>A (p.G12D) | M | 58 | P | 5.5 | 3 | 3 | 1b | IV | Current | No |
54 | c.34G>T (p.G12C) | M | 66 | A | 5.9 | 4 | 3 | 1b | IV | Current | No |
55 | c.34G>T (p.G12C) | M | 55 | S | 7.8 | 3 | 0 | 0 | IIB | Former | No |
61 | c.35G>T (p.G12V) | M | 70 | NA | 4.1 | 2a | 2 | 1a | IV | Current | No |
72 | c.35G>A (p.G12D) | M | 73 | A&P | 2.4 | 1b | 1 | 1a | IV | Former | Yes |
76 | c.35G>A (p.G12D) | M | 66 | A | 2.5 | 1b | 1 | 0 | IIA | Current | No |
80 | c.35G>A (p.G12D) | M | 73 | A&S | 4 | 4 | 3 | 1b | IV | Former | No |
81 | c.35G>T (p.G12V) | M | 75 | S | 3.5 | 4 | 3 | 1a | IV | Former | No |
92a | c.35G>T (p.G12V) | F | 69 | A | 1 | 1a | 0 | 0 | IA | Never | No |
96 | c.35G>C (p.G12A) | M | 55 | A | 4.3 | 2a | 0 | 1a | IV | Current | No |
113 | c.35G>T (p.G12V) | M | 70 | P | 1.9 | 1a | 3 | 1b | IV | Former | No |
133a | c.34G>T (p.G12C) | M | 55 | A | 1.8 | 2a | 2 | 0 | IIIA | Current | Yes |
134 | c.34G>A (p.G12S) | F | 58 | A | 6.9 | 2a | 3 | 1b | IV | Never | No |
Country | KRAS(+) (%) | No, of cases | Method | Patients | Survival relation | |
---|---|---|---|---|---|---|
Guan et al. (2013) [18] | China | 5 | 1,928 | DS or high resolution melting analysis | Operable and inoperable | Yes |
Marchetti et al. (2009) [24] | Italy | 36 | 83 | Mutant-enriched sequencing | Adenocarcinoma | Yes |
Treated with EGFR-TKI | ||||||
Sun et al. (2013) [25] | Korea | 8 | 484 | DS | Advanced stage | Yes |
Johnson et al. (2013) [26] | USA | 23 | 1,036 | DS or mass-spectrometry-based genotyping | Advanced stage | Yes |
Adenocarcinoma | ||||||
Sonobe et al. (2012) [22] | Japan | 18 | 180 | RFLP | Resection | No |
Adenocarcinoma | ||||||
Cadranel et al. (2012) [17] | France | 14 | 522 | DS or nested sequencing | Advanced stage | Yes |
Treated with EGFR-TKI | ||||||
Kerner et al. (2013) [27] | The Netherlands | 30 | 442 | DS | Operable and inoperable | No |
Kim et al. (2012) [19] | Korea | 4 | 229 | DS | Never-smoker | Yes |
Ragusa et al. (2013) [21] | Italy | 17 | 230 | DS | Resection | No |
Kosaka et al. (2009) [20] | Japan | 13 | 397 | DS | Resection | No |
Adenocarcinoma | ||||||
Lim et al. (2009) [28] | Singapore | 6 | 88 | Whole genome amplification and DS | Advanced stage | Yes |
Liu et al. (2010) [29] | Taiwan | 5 | 73 | DS | Resection | No |
Scoccianti et al. (2012) [30] | Europe | 19 | 250 | Mutant-enriched sequencing | Resection | No |