We report a case of congenital bronchogenic cyst associated with cytomegalovirus infection in 50 day old female baby. She was admitted under the impression of pyopneumothorax and bronchopleural fistula. Left lower lobectomy was performed due to persistent symptoms despite of conservative treatment. Histopathologic examination of lobectomized left lower lobe reveals congenital bronchogenic cyst with rupture, infected by cytomegalovirus.