Abstract

Cryptococcal infection is now not so rare a disease in Far East Asia. The author present three cases of systemic cryptococcosis experienced in pathology, P.M.C. Case I had involvement of the liver, spleen, kidney, lymph-nodes, adrenal glands and train, and case II and case III C.N.S. and liver. Numerous cryptococcus neoformans were found in the affected organs and tissues. The author discuss incidence, diagnostic and pathologic problems and drugs. Routine India ink preparation and repeat of spinal fluid examination were emphasized in the cases of meningitis. In ambiguous cases, urine, sputum, blood, bone marrow and stool examination can help identify a fungus infection. Amphotericin-B is the most effective drug to combat fungal infection upto present. 5-fluorocytocine is a new drug, but more evaluation is required because of little experience with it.