Cryptococcosis is widespread throughout the world, which may arise in healthy individuals, but more commonly it occurs as an opportunistic infection, particularly in the immunodeficient persons and those having some form of leukemia, lymphoma or Hodgikin's disease etc. We experienced 4 cases of cryptococcosis. The first case was associated with probable malignant lymphoma in a 64-year old woman who was admitted with complaint of high fever. The second case followed kidney transplantation in a 24-year old man, who was admitted with complaint of multiple subcutaneous nodule on the whole body. The third case involved the cervical lymphnode in a 8-year old boy who was admitted with complaint of palpable mass on the neck. The last case of the four was a disseminated cryptococcosis in a 21-year old woman who was admitted with complaints of high fever and maculopapular eruption. The current concept on the pathogenesis and biological behavior of this entity was discussed, with a brief review of the literature.