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Cytologic Study on Microinvasive Squamous Cell Carcinoma of the Uterine Cervix
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HOME > J Pathol Transl Med > Volume 14(2); 1980 > Article
Etc Cytologic Study on Microinvasive Squamous Cell Carcinoma of the Uterine Cervix
Journal of Pathology and Translational Medicine 1980;14(2):21-30
DOI: https://doi.org/
Department of Pathology, Korea General Hospital
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Cervico-vaginal smears from 10 patients with microinvasive squamous cell carcinoma of the cervix confirmed on the histologic examination of the conization or hysterectomy specimen were retrospectively investigated. 1) The degree of stromal penetration on the histologic examination was estimated as upper (1 case), middle (4 cases) and lower 1/3 (5 cases) of the mucosa equivalent to the length of the cervical mucous glands. The cervico-vaginal smears of the 10 patients obtained prior to the surgical interventions were originally diagnosed as severe dysplasia (3 cases), microinvasive carcinoma (2 cases) and invasive carcinoma (5 cases). 2) On the histological examination the covering epithelium of the microinvasive carcinoma showed a variety of intraepithelial neoplastic changes including dysplasia of variable degrees and in situ carcinoma in some extend. 3) A cytologic analysis on the smears revealed the cells indicating microinvasion in 9.5%(upper 1/3), 26.4% (middle 1/3) and 17.8% (lower 1/3 stromal invasion) as a prevalence among the cells screened. 4) The microinvasive carcinoma cells contained cellular abnormalities which varied somewhat in relation to the depth of penetration. The deeper penetrated the abnormal cells the more smeared in aggregates. A tumor diathesis was evident in 9 of 10 ases. The cells with the deepest penetration (lower 1/3) had an irregularly distributed coarse chromatin and prominent nucleoli, while the abnormal cells with upper 1/3 stromal penetration had a regularly distributed fine chromatin and no prominent nucleoli.

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