Abstract

Eosinophilia has been known to appear in patients with certain parasitic infections, allergies. dermatoses, hypereosinophilic syndrome and malignancies. In recent years. there is growing evidence that actual mechanism of eosinophilia in peripheral blood and tissue may be largely mediated by immune processes. But pathogenesis of eosinophilia in tumor tissue is still debated. In an attempt to understand the immune mechanism in cervical carcinoma, we observed the degree and frequency of eosinophilic infiltration in 180 cases of cervical carcinoma and 118 cases of chronic cervicitis as a control group. The results obtained are as followings. 1. Eosinophilic infiltration in the lesion was noted in 13 cases among 118 cases of cervicitis (11%) and 93 cases among 180 cases of cervical cancer(51.7%). 2. Eosinophilic infiltration in each histologic type of cervical cancer revealed 39% in keratinizing type, 61.2% in non-keratinizing large cell type, 46.2% in non-keratinizing small cell type, showing more frequent infiltration in undifferentiated type. 3. Eosinophilic infiltration cervical cancer revealed no significant difference in frequency or degree by age group of patients. 4. Above findings suggest that eosinophilic infiltration of cervical cancer is cancer specific finding in half of cases and closely related with degree of cancer cell differentiation