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Palmar and plantar fibromatosis: a review
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Review
Palmar and plantar fibromatosis: a review
Brian D. Stewart,1orcid, Alessandra F. Nascimento2orcid
Journal of Pathology and Translational Medicine 2021;55(4):265-270.
DOI: https://doi.org/10.4132/jptm.2021.06.14
Published online: July 7, 2021

1Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA

2CWRU School of Medicine, University Hospitals, Bone and Soft Tissue Pathology, Cleveland, OH, USA

Corresponding Author: Brian D. Stewart, MD, Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, P.O. Box 100275, 1600 SW Archer Road, Gainesville, FL 32610-0275, USA Tel: +1-352-627-9240, Fax: +1-352-627-9242, E-mail: 'bstewart@ufl.edu'
This article has been published jointly, with consent, in both Journal of Pathology and Translational Medicine and PathologyOutlines.com.
• Received: June 5, 2021   • Accepted: June 14, 2021

© 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Palmar fibromatosis (Dupuytren disease/contracture) is the most common type of fibromatosis, defined as a benign proliferation of fibroblasts and myofibroblasts. The disease process is most common in white, middle-aged and older men occurring at the distal palmar crease leading to nodules and contracture, which in many cases recur after surgical treatment. In a similar process, plantar fibromatosis (Ledderhose disease) is a proliferation of fibroblasts and myofibroblasts on the plantar aponeurosis of mostly middle-aged patients that may lead to painful nodules but usually does not lead to contracture. Both processes are histologically similar, composed of a bland cellular proliferation of spindle cells with a bluish appearance and with a variable amount of background collagen, depending on the age of the lesion. The etiology of both lesions is still uncertain, while treatment ranges from observation to surgery, with some pharmacologic agents being investigated with mixed success. In this paper we provide an overview of both processes with regards to clinical and radiologic findings, pathophysiology, diagnosis, treatment, and prognosis.
Palmar and plantar fibromatoses are both benign, superficial, proliferative processes of the palmar and plantar aponeuroses, respectively, caused by the proliferation of fibroblasts and myofibroblasts. Other terms used for this in the clinical setting are Dupuytren disease or contracture for palmar fibromatosis and Ledderhose disease or morbus Ledderhose for plantar fibromatosis. This review will offer insights into the epidemiology, clinical features, pathophysiology, imaging characteristics, treatment, and prognosis of these common entities.
Palmar fibromatosis is the most common type of superficial fibromatosis affecting approximately 1%–2% of the population. The prevalence increases with the patient’s age to where approximately 20% of the population at age 65 suffers from this disease. Males are more often affected, with a male to female ratio of 3–4:1. It can affect both the metacarpophalangeal and proximal interphalangeal joints [1]. Half of the cases affect both hands. Patients of northern European ancestry are most commonly affected and the disease is rare in the black population.
Palmar fibromatosis is associated with diabetes, smoking, repetitive vibrational trauma and is thought to be caused by fibrogenic cytokines [2]. The process is characterized by a proliferation of fibroblasts followed by their differentiation into myofibroblasts and the production of extracellular matrix. Fibroblast growth factor, wingless/integrated (Wnt), and transforming growth factor β have all been proposed as having a role in disease progression [3-7].
The prevalence of plantar fibromatosis is not currently well characterized and is now on the National Institutes of Health list of rare diseases [8]. The disease process usually affects the medial and central bands of the plantar aponeurosis of middle-aged patients, although several reports of patients less than 16 years old to as young as 9 months have been published [9]. Approximately 25% of cases are bilateral with males being more affected than females [10]. A possible genetic predisposition has been suggested, as two genetic variants were found in a genome wide association study where one indel (chr5:118704153:D) and one single nucleotide polymorphism (rs62051384) were detected [11].
The etiology of plantar fibromatosis is not currently understood, but has been associated with long-term phenobarbital use for epilepsy, frozen shoulder, smoking, alcohol addiction, diabetes, and repeated trauma [8,12]. The disease process advances through several phases. There is first the proliferative phase in which increased fibroblastic activity and cellular proliferation is seen. This is followed by the active phase where nodule formation occurs. Finally, there is the residual phase consisting of collagen deposition, scar formation and tissue contracture.
The diagnosis of both plantar and palmar fibromatosis is usually made clinically, although occasionally histologic confirmation may be necessary. Palmar fibromatosis often presents with subcutaneous nodules on the distal volar aspect which puckers the overlying skin as it ages. The process leads to painful flexion contracture, most commonly of digits 4 and 5, due to cord-like expansion of the digital aponeurotic slips (Fig. 1A, B). Deeper structures such as the tendons or skeletal muscle are not involved. Plantar disease is concurrently seen in 10% of patients, while an additional 1%–4% have penile fibromatosis (Peyronie disease). Ultrasound of the hand shows nodules superficial to the flexor tendons in superficial fascia. The early lesions are hypoechoic with hypervascularity while more chronic lesions become more hyperechoic without vascularity [13]. The subcutaneous nodules on magnetic resonance imaging (MRI) are typically uniformly of low signal intensity on both T1 and T2 [14].
Plantar fibromatosis presents with single or multiple slow growing subcutaneous nodules located in the medial or central plantar aponeurosis measuring 0.5 to 3.0 cm in diameter. These are initially painless but are later associated with pain after standing or walking, typically on the medial aspect of the sole. Plantar disease is associated with concomitant palmar and penile fibromatoses, along with keloids. Unlike palmar disease, plantar fibromatosis is usually not associated with contractures [15]. Radiographs of the foot are usually normal. Ultrasonography is seen as superior to MRI, where hypoechogenic to mixed lesions are embedded on the plantar fascia and less reflective to the much brighter plantar fascia surrounding it with sharp juxtaposition [16]. The plantar fascia shows discrete, fusiform, multinodular thickening [17]. Alternating linear bands of hypoechogenicity and isoechogenicity relative to the plantar fascia, known as the Comb sign, is seen in 51% of cases [18]. MRI demonstrates nodules that appear as focal oval-shaped areas of disorganization embedded in the plantar fascia [16]. T1-weighted images show isometric to low signal intensity as compared to muscle, while T2- weighted MRI shows low to intermediate signal [17,19].
Palmar fibromatosis presents macroscopically as small nodules or nodular masses associated with aponeuroses and subcutaneous fat (Fig. 2) with a gray to yellow to white cut surface, the exact nature of the color depending on the amount of collagen content. Cytologic examination is usually limited to touch preparations made during the rare specimen sent for frozen section (Fig. 3A, B). These are usually hypocellular with clusters of bland spindle cells with oval to elongated nuclei. Nuclear atypia and mitotic activity are not present. The microscopic features depend on the age of the lesion. In the proliferative phase, there are uniform,plump, spindle cells (myofibroblasts and fibroblasts) with bland nuclei and indistinct nucleoli, usually with a “bluer” appearance than the surrounding aponeurotic tissue (Figs. 46). The stroma contains a moderate amount of collagen and elongated vessels. In older, less cellular lesions, the collagenous content is denser. Occasionally, attachment to the overlying dermis or cartilaginous metaplasia can be seen. There is usually no infiltration into surrounding tissue beyond the subcutis.
The gross and microscopic characteristics of plantar fibromatosis are similar to its palmar counterpart (Figs. 79). Evans described the presence of a variable number of multinucleated giant cells found during the proliferative phase [20]. The formation of nodules is seen during the active phase while the less cellular, more collagenous residual phase often has a prominent chronic inflammatory component and hemosiderin deposition.
Immunohistochemical studies are usually not necessary for diagnosis due to the characteristic histology of these lesions. Vimentin is uniformly reactive while muscle specific and smooth muscle actins are variable. Infrequently, desmin may show reactivity. Keratins, CD34, epithelial membrane antigen, and S-100 should all be negative. Beta-catenin is negative in plantar fibromatosis, but aberrant nuclear staining in palmar fibromatosis is common [21,22].
Palmar fibromatosis is usually considered a reactive, as opposed to neoplastic, lesion [23]. The lesions are near diploid, often with trisomy 7 or 8, and show no gene amplifications or deletions [24]. Loss of the Y chromosome may be seen [25]. Aberrations in the Wnt signaling pathway are common; however, no somatic mutations of beta-catenin genes, as seen in desmoid fibromatosis, are present [6,22,26,27].
Like palmar fibromatosis, plantar fibromatosis is near diploid, often with trisomy 7 or 8, and does not contain somatic mutations of beta-catenin genes [22]. Trisomy 14 has also been reported, along with a case containing a clonal reciprocal t(2;7) (p13;p13) [28,29].
The clinical, gross, and histologic features of palmar and plantar fibromatosis are quite characteristic and the diagnosis is usually straightforward. However, it is important to keep in mind some of the differential diagnoses. Spindle cell sarcomas, such as synovial sarcoma and malignant peripheral nerve sheath tumor (MPNST), and epithelioid sarcoma should not be missed as the treatment and prognosis is vastly different. Epithelioid sarcoma commonly presents in the hand but cells will show a distinctive epithelioid appearance with abundant eosinophilic cytoplasm. Central necrosis and/or hyalinization is often seen. Epithelioid sarcoma is characteristically reactive for cytokeratins and CD34 and shows a loss of nuclear staining for SMARCB1 (INI-1).
Clinically, plantar fibromatosis that has not formed nodules may be confused with a calcaneal stress fracture, tarsal tunnel syndrome, or plantar fasciitis [10]. With the development of nodules, malignancies such as melanoma, synovial sarcoma, and Kaposi sarcoma may be of concern. On a histologic level, calcifying aponeurotic fibroma can be excluded as plump or epithelioid fibroblasts palisading around cartilage and spotty calcification is seen in this entity and not in plantar fibromatosis. As in the hand, desmoid-type fibromatosis is rare in the feet and infiltrates skeletal muscle. These lesions are also usually greater than 3 cm and often shows nuclear beta-catenin reactivity in more than 80% of cases. Plantar fibromatosis also may raise the differential diagnoses of synovial sarcoma and MPNST. If these are of concern, fluorescence in situ hybridization (SS18) and immunohistochemistry (i.e., S-100, SOX-10, H3K27me3) may be employed to assist in this differential.
Observation is an option for palmar fibromatosis, while excision or incision of the contracture band may be necessary if the contracture results in functional disability and the total flexion deformity is greater than 30 degrees [30] (Figs. 10A, B). Unfortunately, the lesion often recurs. Collagenase (clostridial collagenase histolyticum) has been recently investigated as a treatment option [8,30,31]. The disease course seems to cause greater morbidity for white men with a strong family history, those with bilateral involvement, severe disease and ectopic manifestations [32].
As with palmar fibromatosis, conservative measures should be used for plantar fibromatosis prior to recommending surgery. If surgery is performed for symptomatic lesions, complete fasciectomy has fewer recurrences than local and wide excisions [8,10,33]. Along with collagenase, several nonoperative treatments such as steroid injections, verapamil, radiation therapy, extracorporeal shock wave therapy, and tamoxifen have all had variable scientific support [10]. Those with bilateral involvement, multiple nodules, and a positive family history have a worse prognosis [34].
Palmar and plantar fibromatoses are related entities that together form a relatively common diagnostic group encountered in surgical pathology. Further study is needed to ascertain the etiology of these diseases as treatment options currently are limited with a high rate of recurrence. Recognizing the basic clinical, radiographic, and pathologic features is important to arrive at the correct diagnosis.

Ethics Statement

Not applicable.

Availability of Data and Material

Data sharing not applicable to this article as no datasets were generated or analyzed during the study.

Code Availability

Not applicable.

Author Contributions

Investigation: BDS. Project administration: BDS. Visualization: BDS, AFN. Writing—original draft: BDS. Writing—review & editing: BDS, AFN. Approval of final manuscript: all authors.

Conflicts of Interest

The authors declare that they have no potential conflicts of interest.

Funding Statement

No funding to declare.

The authors would like to thank Chung M. Chan, M.D., for the contribution of the clinical photos of palmar fibromatosis.
Fig. 1.
(A, B) Bilateral nodules in the distal palmar crease and contractures involving the fourth digit.
jptm-2021-06-14f1.jpg
Fig. 2.
Excised contraction band of palmar fibromatosis with surrounding soft tissue.
jptm-2021-06-14f2.jpg
Fig. 3.
(A, B) Touch prep of a specimen sent for frozen section showing clusters of loosely arranged spindle cells with bland fusiform nuclei without atypia or mitotic figures.
jptm-2021-06-14f3.jpg
Fig. 4.
Immature fibroblastic proliferation (lower 1/2) well-demarcated from the involved tendon (upper 1/2).
jptm-2021-06-14f4.jpg
Fig. 5.
Higher magnification showing the immature fibroblastic proliferation (lower 2/3 of the field) involving normal fibrous tissue (upper 1/3).
jptm-2021-06-14f5.jpg
Fig. 6.
Tendinous tissue with interspersed fascicles of a bland appearing immature spindle cell proliferation in both longitudinal and cross sections.
jptm-2021-06-14f6.jpg
Fig. 7.
Nodular proliferation of immature fibroblasts and myofibroblasts embedded within the plantar aponeurosis.
jptm-2021-06-14f7.jpg
Fig. 8.
Large nodule of immature fibroblasts and myofibroblasts (lower 1/2) with pushing and locally infiltrating borders into the plantar aponeurotic tissue (upper 1/2).
jptm-2021-06-14f8.jpg
Fig. 9.
Cellular proliferation of immature fibroblasts and myofibroblasts with plump to fusiform nuclei (left) well demarcated from the less cellular and more collagenous plantar fascia (right).
jptm-2021-06-14f9.jpg
Fig. 10.
(A, B) Patient from Fig. 1 after removal of the contraction band and resolution of the contracture of the fourth digits.
jptm-2021-06-14f10.jpg
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